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公开(公告)号：US20050166925A1
公开(公告)日：2005-08-04
申请号：US11092123
申请日：2005-03-28
Applicant: Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
Inventor： Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
CPC classification number: A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
Abstract: Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway and includes a valve protector that at least partially surrounds a valve member. The valve protector has sufficient rigidity to maintain the shape of the valve member against compression.
Abstract translation: 描述了患者肺容积减少的方法和系统。 所述方法包括在肺的支气管通道中植入流量控制装置。 流量控制装置调节通过支气管通道的流体流动并且包括至少部分地围绕阀构件的阀保护器。 阀保护器具有足够的刚性以保持阀构件的形状不被压缩。
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公开(公告)号：US20050080338A1
公开(公告)日：2005-04-14
申请号：US10961581
申请日：2004-10-08
Applicant: D. Sirimanne , Douglas Sutton , Natalie Fawzi , Gail Lebovic
Inventor： D. Sirimanne , Douglas Sutton , Natalie Fawzi , Gail Lebovic
CPC classification number: A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
Abstract: These are breast implant devices and methods of use. The breast implants are made of a matrix of collagen material having a porous structure for supporting surrounding tissue of a breast. The implants are also configured to provide a framework for the in-growth of fibrous tissue into the matrix. The matrix can be resilient and/or self-expanding. The methods of use include the steps of forming a cavity having surrounding breast tissue and forming a resorbable implant made up of collagen that is sized to occupy the cavity. The implant is then implanted into the cavity, thereby supporting the surrounding tissue and allowing for in-growth of fibrous tissue into and replacing the resorbable material. The resorbable material may also be elastically compressible, such that the step of implanting includes the step of compressing the resorbable material. The implants may also contain a medicinal, therapeutic, or diagnostic substance.
Abstract translation: 这些是乳房植入装置和使用方法。 乳房植入物由具有用于支撑乳房周围组织的多孔结构的胶原材料基质制成。 植入物还被配置为提供用于将纤维组织生长成基质的框架。 基质可以是弹性的和/或自膨胀的。 使用的方法包括形成具有周围乳房组织的空腔的步骤，并形成由胶原构成的可再吸收的植入物，其尺寸适于占据空腔。 然后将植入物植入空腔中，从而支撑周围的组织并允许纤维组织的生长进入并替换可再吸收的材料。 可吸收材料也可以是可弹性压缩的，使得植入步骤包括压缩可再吸收材料的步骤。 植入物还可以含有药物，治疗或诊断物质。
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公开(公告)号：US20050080337A1
公开(公告)日：2005-04-14
申请号：US10961491
申请日：2004-10-07
Applicant: D. Sirimanne , Douglas Sutton , Natalie Fawzi , Gail Lebovic
Inventor： D. Sirimanne , Douglas Sutton , Natalie Fawzi , Gail Lebovic
CPC classification number: A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
Abstract: These are biopsy site marking devices. More particularly, the devices include a body of gelatin and an x-ray detectable body of a specific, predetermined non-biological configuration embedded in the body of gelatin. In one embodiment, the x-ray detectable body is made from metal. In alternative embodiments, the x-ray detectable body can be made from stainless steel or metal oxides.
Abstract translation: 这些是活检现场标记装置。 更具体地说，这些装置包括一个明胶体和一个嵌入明胶体内的特定的预定非生物构型的x射线可检测体。 在一个实施例中，X射线可检测体由金属制成。 在替代实施例中，X射线可检测体可以由不锈钢或金属氧化物制成。
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公开(公告)号：US20130253471A1
公开(公告)日：2013-09-26
申请号：US13898830
申请日：2013-05-21
Applicant: Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
Inventor： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
IPC: A61N1/05
CPC classification number: A61B18/12 , A61B18/04 , A61B18/1492 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00648 , A61B2018/00791 , A61B2018/00875 , A61N1/0551 , A61N1/36117 , A61N7/00 , A61N2007/003
Abstract: Methods and apparatus are provided for treating contrast nephropathy, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation of electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
Abstract translation: 提供了用于通过脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗对比肾病的方法和装置。这种神经调节可以实现电融合的坏死性电穿孔，坏死 和/或诱导细胞凋亡，改变基因表达，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。 在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中，这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。
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公开(公告)号：US20130165860A1
公开(公告)日：2013-06-27
申请号：US13615229
申请日：2012-09-13
Applicant: Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, JR. , Douglas Sutton , Kathleen Cogan Farinas
Inventor： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, JR. , Douglas Sutton , Kathleen Cogan Farinas
CPC classification number: A61F9/0008 , A61F9/0017 , A61M5/141 , A61M5/14276 , A61M5/3202 , A61M5/3291 , A61M5/46 , A61M25/007 , A61M39/0247 , A61M2025/0031 , A61M2025/0039 , A61M2039/0081 , A61M2039/009 , A61M2039/027 , A61M2039/0276 , A61M2039/0294 , A61M2205/6045 , A61M2205/6054 , A61M2209/045 , A61M2210/0612
Abstract: An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.
Abstract translation: 注射器装置包括具有一个或多个开口的细长结构，其可定位在可植入装置的可穿透屏障附近，以便容纳可植入装置的流体。 该装置包括在针的至少一部分上延伸的针和护套。 细长结构可以包括穿透组织和可穿透屏障的远端尖端，以及靠近尖端的远端开口以将治疗流体释放到可植入腔室中。 在许多实施例中，远端尖端，远侧开口和多个开口与接合患者组织的止挡分开并限制穿透深度，使得远端开口和多个开口沿着可植入的轴线 设备提高交换效率。
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Patent Agency Ranking
公开(公告)号：US20130070200A1
公开(公告)日：2013-03-21
申请号：US13503842
申请日：2010-10-25
Applicant: Eugene de Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
Inventor： Eugene de Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
CPC classification number: G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
Abstract: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
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公开(公告)号：US08357139B2
公开(公告)日：2013-01-22
申请号：US12264849
申请日：2008-11-04
Applicant: Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
Inventor： Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
CPC classification number: F16K15/147 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/04 , A61F2/24 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , Y10S128/912
Abstract: Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control element is guided to and positioned at the site by a bronchoscope that is introduced into the patient's trachea and used to view the lungs during delivery of the flow control element. The valve may include one, two or more valve elements, and it may be collapsible for easier delivery. A source of vacuum or suction may be used to increase the amount of fluid withdrawn from the lung tissue. A device for measuring hollow structures, such as bronchioles, and a device for removing a previously-placed flow control element are disclosed as well.
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公开(公告)号：US08150520B2
公开(公告)日：2012-04-03
申请号：US11368949
申请日：2006-03-06
Applicant: Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
Inventor： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
CPC classification number: A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
Abstract: Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
Abstract translation: 提供了用于通过脉冲电场经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗终末期肾脏疾病的方法和装置。这种神经调节可以实现不可逆的电穿孔或 电融合，坏死和/或诱导凋亡，基因表达改变，动作电位衰减或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。 在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中，这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。
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公开(公告)号：US20100222851A1
公开(公告)日：2010-09-02
申请号：US12777892
申请日：2010-05-11
Applicant: Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
Inventor： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
CPC classification number: A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
Abstract translation: 提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。 预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗 晚期肾脏疾病。 本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。
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公开(公告)号：US07653438B2
公开(公告)日：2010-01-26
申请号：US11129765
申请日：2005-05-13
Applicant: Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
Inventor： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
CPC classification number: A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
Abstract translation: 提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。 预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗 晚期肾脏疾病。 本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。
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