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    Serial electrophoresis
    1.
    发明授权
    Serial electrophoresis 有权

    公开(公告)号：US11592421B2

    公开(公告)日：2023-02-28

    申请号：US16616339

    申请日：2018-05-22

    Applicant: Integenx Inc.

    Inventor： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC: G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: Disclosed are methods for performing capillary electrophoresis on two or more nucleic acid samples. The methods employ a forward voltage to move a first sample forward from an inlet to an interrogation region in the capillary, then a backward voltage to move the first sample backward, and then a forward voltage again to move the first sample and a second sample forward. Systems and apparatuses for performing capillary electrophoresis are also provided.

    UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM
    2.
    发明申请
    UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
    通用样品制备系统及其在综合分析系统中的应用

    公开(公告)号：US20140170645A1

    公开(公告)日：2014-06-19

    申请号：US13967957

    申请日：2013-08-15

    Applicant: IntegenX Inc.

    Inventor： Stevan B. Jovanovich ,  William D. Nielsen ,  David S. Cohen ,  Michael Recknor ,  Mattias Vangbo ,  Ezra Van Gelder ,  Lars Majlof ,  Omar El-Sissi

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  G01J3/4406 ,  G01N1/31 ,  G01N1/405 ,  G01N21/64 ,  G01N27/44721 ,  G01N27/44791 ,  G01N27/745 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/00247 ,  G01N2201/06113 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

    Abstract translation: 本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。 例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。 该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。 在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。 在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。 墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。 该系统适合不超过10英尺3的外壳。 并且可以是封闭的，便携式的和/或电池供电的系统。 该系统可用于在不到4小时内从原始样品进行分析。

    SERIAL ELECTROPHORESIS
    3.
    发明申请
    SERIAL ELECTROPHORESIS 有权

    公开(公告)号：US20250060332A1

    公开(公告)日：2025-02-20

    申请号：US18935935

    申请日：2024-11-04

    Applicant: IntegenX Inc.

    Inventor： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC: G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: A system for outputting electropherograms includes a capillary containing a separation medium and comprising an inlet end, a distal end, and an interrogation region between the inlet and distal ends, the inlet end of the capillary configured to receive a plurality of differing samples containing DNA fragments having a plurality of different sizes; a power source configured to selectively apply forward and reverse polarity voltages between the inlet end and the distal end of the capillary; a detector configured to detect signal associated with DNA fragments moving through the interrogation region of the capillary; and a processor communicatively coupled to the detector and configured to process signal detected by the detector and output electropherograms during an electrophoresis run, the electropherograms corresponding to a plurality of differing samples successively introduced to the capillary from the inlet and traveling through the capillary at the same time.

    Serial electrophoresis
    4.
    发明授权
    Serial electrophoresis 有权

    公开(公告)号：US12135309B2

    公开(公告)日：2024-11-05

    申请号：US18157274

    申请日：2023-01-20

    Applicant: IntegenX, Inc.

    Inventor： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC: G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: A system for performing capillary electrophoresis of multiple samples comprises a capillary containing a separation medium and having inlet and distal ends and an interrogation region; a power source configured to apply voltages between inlet and distal ends; and logic to cause execution of: applying a first substantially constant forward polarity electrophoresis voltage to the capillary; before all of the first DNA fragments have passed the interrogation region, applying a reverse polarity voltage pulse to the capillary, thereby transporting at least some of the first DNA fragments in the capillary toward the capillary inlet; introducing a second sample to the capillary inlet, the second sample comprising second DNA fragments having a plurality of different sizes; and applying a second substantially constant forward polarity electrophoresis voltage to the capillary to simultaneously perform electrophoresis on the second DNA fragments and the first DNA fragments.

    CONTROLLING DNA CONCENTRATION FOR STR ANALYSIS
    5.
    发明申请
    CONTROLLING DNA CONCENTRATION FOR STR ANALYSIS 有权

    公开(公告)号：US20220016632A1

    公开(公告)日：2022-01-20

    申请号：US17311263

    申请日：2019-12-04

    Applicant: Integenx, Inc.

    Inventor： Mattias Vangbo ,  David King

    IPC: B01L3/00 ,  C12Q1/6858 ,  B01L7/00

    Abstract: Performing sample quantitation and sample amplification may be performed in a sample cartridge or sample cartridges. Sample quantitation using qPCR may be performed during STR PCR on the sample. Samples need not be normalized prior to performing STR PCR. In certain embodiments, qPCR and STR PCR are performed on the same cartridge, optionally at the same time (or in real-time, or overlapping in time) and optionally using some or all of the same PCR apparatus. In other embodiments, qPCR and STR PCR are performed on different cartridges. Quantitation of the STR PCR sample may be performed without substantially delaying the STR PCR process.

    SERIAL ELECTROPHORESIS
    10.
    发明公开
    SERIAL ELECTROPHORESIS 审中-公开

    公开(公告)号：US20230152274A1

    公开(公告)日：2023-05-18

    申请号：US18157274

    申请日：2023-01-20

    Applicant: IntegenX, Inc.

    Inventor： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC: G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    CPC classification number: G01N27/44713 ,  C12Q1/6806 ,  C12Q1/686 ,  G01N27/44791 ,  C12Q2565/125 ,  G01N27/44721

    Abstract: A system for performing capillary electrophoresis of multiple samples comprises a capillary containing a separation medium and having inlet and distal ends and an interrogation region; a power source configured to apply voltages between inlet and distal ends; and logic to cause execution of: applying a first substantially constant forward polarity electrophoresis voltage to the capillary; before all of the first DNA fragments have passed the interrogation region, applying a reverse polarity voltage pulse to the capillary, thereby transporting at least some of the first DNA fragments in the capillary toward the capillary inlet; introducing a second sample to the capillary inlet, the second sample comprising second DNA fragments having a plurality of different sizes; and applying a second substantially constant forward polarity electrophoresis voltage to the capillary to simultaneously perform electrophoresis on the second DNA fragments and the first DNA fragments.

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