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    Sample preparation, processing and analysis systems
    1.
    发明授权
    Sample preparation, processing and analysis systems 有权

    公开(公告)号：US12168798B2

    公开(公告)日：2024-12-17

    申请号：US17119874

    申请日：2020-12-11

    Applicant: Integenx Inc.

    Inventor： David Eberhart ,  Yuan Li ,  James Ogg ,  Ezra Van Gelder ,  Stephen J. Williams ,  Timothy Woudenberg ,  Dean S. Burgi ,  William D. Nielsen

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00 ,  G01N27/447 ,  G01N35/00

    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

    Cartridges and Instruments for Sample Analysis
    6.
    发明申请
    Cartridges and Instruments for Sample Analysis 有权

    公开(公告)号：US20210278427A1

    公开(公告)日：2021-09-09

    申请号：US17211212

    申请日：2021-03-24

    Applicant: INTEGENX INC.

    Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

    IPC: G01N35/00 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888

    Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

    Cartridges and instruments for sample analysis
    7.
    发明授权
    Cartridges and instruments for sample analysis 有权

    公开(公告)号：US10989723B2

    公开(公告)日：2021-04-27

    申请号：US16258412

    申请日：2019-01-25

    Applicant: IntegenX Inc.

    Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

    IPC: B01L3/00 ,  G01N35/00 ,  B01L7/00 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888

    Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

    Systems and methods for live help
    9.
    发明授权
    Systems and methods for live help 有权

    公开(公告)号：US10725801B2

    公开(公告)日：2020-07-28

    申请号：US15761066

    申请日：2016-09-21

    Applicant: IntegenX Inc.

    Inventor： David King ,  Chungsoo Charles Park

    IPC: G06F3/0481 ,  G06F9/451 ,  G06F3/0487 ,  G06Q30/00

    Abstract: A live help system provides an intuitive display of help information on a user's graphical user interface. A request is received from a client device for help, and a live help provider interface is initiated at a live help location. Data is acquired regarding a user's location, including data on external devices in the user's location. Indicators are provided to allow the live help provider to point to or otherwise indicate items on the user interface or outside of the user interface. Live help input is captured at the live help provider interface. Instructions are then transmitted to the display of the client device to display live help input, as though the agent were present and interacting with or indicating items on the screen or off the screen.

    Serial electrophoresis
    10.
    发明授权
    Serial electrophoresis 有权

    公开(公告)号：US11592421B2

    公开(公告)日：2023-02-28

    申请号：US16616339

    申请日：2018-05-22

    Applicant: Integenx Inc.

    Inventor： Mattias Vangbo ,  David King ,  Arnaldo Barican

    IPC: G01N27/447 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: Disclosed are methods for performing capillary electrophoresis on two or more nucleic acid samples. The methods employ a forward voltage to move a first sample forward from an inlet to an interrogation region in the capillary, then a backward voltage to move the first sample backward, and then a forward voltage again to move the first sample and a second sample forward. Systems and apparatuses for performing capillary electrophoresis are also provided.

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