公开(公告)号：US10767225B2

公开(公告)日：2020-09-08

申请号：US16264389

申请日：2019-01-31

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: C12Q1/6874 ,  C12Q1/686 ,  B01L3/00 ,  F16K99/00 ,  B01L7/00 ,  B01F13/00 ,  B01F13/02

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.

公开(公告)号：US20190256890A1

公开(公告)日：2019-08-22

申请号：US16250646

申请日：2019-01-17

Applicant: IntegenX, Inc.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey M. Smith ,  Philip Justus Wunderle ,  David King

IPC: C12Q1/6806 ,  B01L3/00 ,  C12Q1/686 ,  G01N27/447

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

公开(公告)号：US10208332B2

公开(公告)日：2019-02-19

申请号：US15117053

申请日：2015-04-30

Applicant: IntegenX Inc.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey Smith ,  Philip Justus Wunderle ,  David King

IPC: A61J1/06 ,  B01L3/00 ,  G01N21/00 ,  G01N15/06 ,  C12Q1/6806 ,  C12Q1/686 ,  G01N27/447

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

公开(公告)号：US12152272B2

公开(公告)日：2024-11-26

申请号：US18527656

申请日：2023-12-04

Applicant: IntegenX Inc.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey M. Smith ,  Philip Justus Wunderle ,  David King

IPC: C12Q1/6806 ,  B01L3/00 ,  C12Q1/686 ,  G01N27/447

Abstract: An instrument includes a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to close off a fluidic channel in the body. A cartridge interface is configured to engage the cartridge.

公开(公告)号：US20240175075A1

公开(公告)日：2024-05-30

申请号：US18527656

申请日：2023-12-04

Applicant: IntegenX Inc.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey M. Smith ,  Philip Justus Wunderle ,  David King

IPC: C12Q1/6806 ,  B01L3/00 ,  C12Q1/686 ,  G01N27/447

CPC classification number: C12Q1/6806 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  C12Q1/686 ,  G01N27/44743 ,  G01N27/44791 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0478

Abstract: An instrument includes a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to close off a fluidic channel in the body. A cartridge interface is configured to engage the cartridge.

公开(公告)号：US11891650B2

公开(公告)日：2024-02-06

申请号：US17181228

申请日：2021-02-22

Applicant: INTEGENX, INC.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey M. Smith ,  Philip Justus Wunderle ,  David King

IPC: C12Q1/6806 ,  B01L3/00 ,  C12Q1/686 ,  G01N27/447

CPC classification number: C12Q1/6806 ,  B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  C12Q1/686 ,  G01N27/44743 ,  G01N27/44791 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0848 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0478 ,  C12Q1/6806 ,  C12Q1/6846 ,  C12Q2565/629

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

公开(公告)号：US10961561B2

公开(公告)日：2021-03-30

申请号：US16250646

申请日：2019-01-17

Applicant: IntegenX, Inc.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey M. Smith ,  Philip Justus Wunderle ,  David King

IPC: B01L3/00 ,  G01N1/10 ,  C12Q1/6806 ,  C12Q1/686 ,  G01N27/447

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

公开(公告)号：US20230392203A1

公开(公告)日：2023-12-07

申请号：US18312197

申请日：2023-05-04

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: C12Q1/6874 ,  C12Q1/686 ,  B01L3/00 ,  F16K99/00

CPC classification number: C12Q1/6874 ,  C12Q1/686 ,  B01L3/502738 ,  F16K99/0015 ,  F16K99/0034 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  B01L3/502753 ,  B01L7/52

Abstract: A method of controlling fluid flow in a fluid channel of fluidic cartridge can include closing a valve by actuating a mechanical actuator against the valve to force a deformable layer against walls of a valve body, wherein the valve body comprises a valve inlet and a valve outlet and each of the valve inlet and valve outlet are fluidically coupled to a fluidic channel; releasing the valve by retracting the mechanical actuator away from the valve body; and moving liquid through the valve by applying positive or negative pressure to the fluidic channel.

公开(公告)号：US11649496B2

公开(公告)日：2023-05-16

申请号：US16983796

申请日：2020-08-03

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: B01L3/00 ,  F16K99/00 ,  B01L7/00 ,  B01F33/30 ,  B01F33/40 ,  C12Q1/6874 ,  C12Q1/686

CPC classification number: C12Q1/6874 ,  B01L3/502738 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  B01F33/30 ,  B01F33/40 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: A method of making an article bonding a layer of deformable material to a surface of a cartridge body having at least one valve body thereon to seal the at least one valve body, the valve body comprising a valve floor and valve walls comprising upper parts, wherein the valve floor is recessed from the surface and the valve walls extend from the surface to the valve floor, and wherein the valve body comprises walls that are curved or sloped in a direction that is non-normal to the plane defined by the surface; and deforming the layer such that upon release of a force causing the deformation, the layer is in contact with the upper parts of the valve walls and is in spaced from the valve floor so as to bias the valve to an open state.

公开(公告)号：US20190233888A1

公开(公告)日：2019-08-01

申请号：US16264389

申请日：2019-01-31

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: C12Q1/6874 ,  C12Q1/686 ,  F16K99/00 ,  B01L3/00

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01F13/02 ,  B01L3/502738 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.