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公开(公告)号：US11344849B2
公开(公告)日：2022-05-31
申请号：US15565307
申请日：2016-06-07
发明人： Qihua Xu , Alexander G. Lastovich
摘要： A filtration cell (10) for a biological sample including an upper chamber for receiving the biological sample to be filtered, a lower chamber in fluid communication with the upper chamber, and a filtration membrane (14) positioned between the upper chamber and the lower chamber is disclosed. A surface of the filtration membrane has a contact angle >90°. The flow of the biological sample through the upper chamber may be tangential to the filtration membrane and a filtrate passing through the filtration membrane may be collected in the lower chamber. Also, a method of filtering a biological sample including passing the biological sample through an upper chamber of a filtration cell as described above and collecting a filtrate in the lower chamber is disclosed.
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公开(公告)号：US10709370B2
公开(公告)日：2020-07-14
申请号：US15618570
申请日：2017-06-09
发明人： Qihua Xu , Gonghao Wang
摘要： A blood separation device adapted to receive a blood sample having a whole blood portion and a plasma portion is disclosed. The blood separation device includes a housing defining a first chamber, a second chamber, and a separation member disposed therebetween. The blood separation device also includes an actuator, wherein actuation of the actuator draws the blood sample into the first chamber and the separation member is adapted to allow the plasma portion to pass through the separation member to the second chamber. The blood separation device matches the plasma chamber volume, the blood chamber volume, and the applied single pressure source so that the correct trans-membrane pressure and shear rate is obtained.
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公开(公告)号：US10549242B2
公开(公告)日：2020-02-04
申请号：US15565326
申请日：2016-06-07
发明人： Qihua Xu , Alexander G. Lastovich
摘要： A filtration cell (10) for a biological sample having an outer housing (12) defining a first chamber and an inner housing (14) defining a second chamber is disclosed. The inner housing is disposed within the first chamber and rotatable with respect to the outer housing and at least a portion of the inner housing includes a filtration membrane (52). Upon rotation of the inner housing, a first portion of the biological sample passes from the first chamber into the second chamber and a second portion of the biological sample is restrained in the first chamber. Alternatively, the filtration cell may also include a rotation element disposed in the inner housing. Upon rotation of the rotation element with respect to the inner housing, a first portion of the biological sample to passes from the second chamber into the first chamber and a second portion of the biological sample is restrained in the second chamber.
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公开(公告)号：US20170354362A1
公开(公告)日：2017-12-14
申请号：US15618570
申请日：2017-06-09
发明人： Qihua Xu , Gonghao Wang
摘要： A blood separation device adapted to receive a blood sample having a whole blood portion and a plasma portion is disclosed. The blood separation device includes a housing defining a first chamber, a second chamber, and a separation member disposed therebetween. The blood separation device also includes an actuator, wherein actuation of the actuator draws the blood sample into the first chamber and the separation member is adapted to allow the plasma portion to pass through the separation member to the second chamber. The blood separation device matches the plasma chamber volume, the blood chamber volume, and the applied single pressure source so that the correct trans-membrane pressure and shear rate is obtained.
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公开(公告)号：US20170252706A1
公开(公告)日：2017-09-07
申请号：US15447859
申请日：2017-03-02
发明人： Qihua Xu , Kristin Weidemaier , Christopher Basciano , Sivaramakrishnan Balasubramanian , Patrick Downie
CPC分类号： B01D71/50 , A61M1/16 , A61M1/34 , A61M2205/3331 , B01D29/0004 , B01D63/02 , B01D63/08 , B01D69/06 , G01N33/491
摘要： A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
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公开(公告)号：US11344851B2
公开(公告)日：2022-05-31
申请号：US16658350
申请日：2019-10-21
发明人： Qihua Xu , Kristin Weidemaier , Christopher Basciano , Sivaramakrishnan Balasubramanian , Patrick Downie
摘要： A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
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公开(公告)号：US20180056006A1
公开(公告)日：2018-03-01
申请号：US15556917
申请日：2016-03-17
CPC分类号： A61M5/31513 , A61M5/3129 , A61M5/31565 , A61M2005/31521 , A61M2205/0216 , A61M2205/0222 , A61M2207/00
摘要： A time-of-use activated syringe assembly includes a syringe barrel defining a chamber, a plunger rod having a forward attachment end located within the chamber of the barrel, and a stopper located within the chamber of the barrel and including a rearward end adapted to receive the plunger rod. The stopper includes a first perimetrical skirt extending around an outer circumference thereof and extending toward a front end of the stopper. An activation mechanism is associated with at least one of the stopper and the plunger rod, and the plunger rod is configured for transition between a pre-loaded position in which the activation mechanism is unactivated and a loaded position in which the activation mechanism is activated. Upon activation, the activation mechanism applies a radial force to the first perimetrical skirt causing the skirt to seal against an inner wall of the syringe barrel.
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公开(公告)号：US11305241B2
公开(公告)日：2022-04-19
申请号：US16658350
申请日：2019-10-21
发明人： Qihua Xu , Kristin Weidemaier , Christopher Basciano , Sivaramakrishnan Balasubramanian , Patrick Downie
摘要： A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
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公开(公告)号：US20210378567A1
公开(公告)日：2021-12-09
申请号：US17340788
申请日：2021-06-07
摘要： A blood separation device that allows high quality plasma to be generated using a single power source. The device includes a housing with an inlet port adapted to receive the blood sample, a first chamber having a first chamber flow channel in fluid communication with the inlet port, a second chamber having a second chamber flow channel, a separation member disposed between the first chamber and the second chamber. In some embodiments, the blood separation device detects or tests for the presence of a substance, such as an antigen or an antibody.
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公开(公告)号：US20180056243A1
公开(公告)日：2018-03-01
申请号：US15565326
申请日：2016-06-07
发明人： Qihua Xu , Alexander G. Lastovich
CPC分类号： B01D63/16 , A61M1/262 , A61M1/3496 , B01D61/147 , B01D61/18 , B01D63/062 , B01D69/02 , B01D71/50 , B01D2313/04 , B01D2315/02 , B01D2315/04 , B01D2325/04 , B01D2325/06
摘要： A filtration cell (10) for a biological sample having an outer housing (12) defining a first chamber and an inner housing (14) defining a second chamber is disclosed. The inner housing is disposed within the first chamber and rotatable with respect to the outer housing and at least a portion of the inner housing includes a filtration membrane (52). Upon rotation of the inner housing, a first portion of the biological sample passes from the first chamber into the second chamber and a second portion of the biological sample is restrained in the first chamber. Alternatively, the filtration cell may also include a rotation element disposed in the inner housing. Upon rotation of the rotation element with respect to the inner housing, a first portion of the biological sample to passes from the second chamber into the first chamber and a second portion of the biological sample is restrained in the second chamber.
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