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公开(公告)号：US20090312196A1
公开(公告)日：2009-12-17
申请号：US12483089
申请日：2009-06-11
CPC分类号： C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for generating libraries of polynucleotide variants comprising defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开涉及生成包含相对于参照多核苷酸的确定的核苷酸差异的多核苷酸变体文库的方法。
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公开(公告)号：US08383346B2
公开(公告)日：2013-02-26
申请号：US12562988
申请日：2009-09-18
申请人： Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox , Vesna Mitchell , Bumshik Robert Pak , Lynne Gilson
发明人： Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox , Vesna Mitchell , Bumshik Robert Pak , Lynne Gilson
CPC分类号： C12N15/1086 , C12N15/102 , C12N15/1093 , C12Q1/6876 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开涉及用于有效合成，克隆，转化和筛选多核苷酸变体的大型不同文库的方法，其包含相对于参照多核苷酸的明确的核苷酸差异。
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3.发明申请COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR 有权用于生产立体纯静止物及其合成中间体的组合物和方法公开(公告)号：US20080248539A1
公开(公告)日：2008-10-09
申请号：US11865696
申请日：2007-10-01
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
IPC分类号： C12P7/62 , C12N9/02 , C07H21/04 , C07D207/34 , C07C69/675 , C12N1/21
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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4.发明申请公开(公告)号：US20130040364A1
公开(公告)日：2013-02-14
申请号：US13571248
申请日：2012-08-09
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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5.发明授权Engineered ketoreductases and methods for producing stereoisomerically pure statins 有权工程化的酮还原酶和立体异构体纯的他汀类药物的制备方法公开(公告)号：US08273547B2
公开(公告)日：2012-09-25
申请号：US12978022
申请日：2010-12-23
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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6.发明申请Compositions and Methods for Producing Stereoisomerically Pure Statins and Synthetic Intermediates Therefor 有权用于制备立体异构体纯他汀及其合成中间体的组合物和方法公开(公告)号：US20110195465A1
公开(公告)日：2011-08-11
申请号：US12978022
申请日：2010-12-23
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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公开(公告)号：US07879585B2
公开(公告)日：2011-02-01
申请号：US11865696
申请日：2007-10-01
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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8.发明授权Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor 有权编码用于产生立体异构体纯他汀的酮还原酶的多核苷酸及其合成中间体公开(公告)号：US08617864B2
公开(公告)日：2013-12-31
申请号：US13571248
申请日：2012-08-09
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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公开(公告)号：US20100093560A1
公开(公告)日：2010-04-15
申请号：US12562988
申请日：2009-09-18
CPC分类号： C12N15/1086 , C12N15/102 , C12N15/1093 , C12Q1/6876 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开涉及用于有效合成，克隆，转化和筛选多核苷酸变体的大型不同文库的方法，其包含相对于参照多核苷酸的明确的核苷酸差异。
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