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    Nanopore-based sequencing with varying voltage stimulus
    1.
    发明授权
    Nanopore-based sequencing with varying voltage stimulus 有权

    公开(公告)号：US12228539B2

    公开(公告)日：2025-02-18

    申请号：US17447048

    申请日：2021-09-07

    Applicant: Roche Sequencing Solutions, Inc.

    Inventor： Roger J. A. Chen ,  J. William Maney, Jr. ,  Hui Tian

    IPC: G01N27/22 ,  C12Q1/6869 ,  G01N27/447 ,  G01N33/487

    Abstract: A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.

    Systems and methods for capillary electrophoresis, isoelectric point, and molecular weight analysis
    4.
    发明授权
    Systems and methods for capillary electrophoresis, isoelectric point, and molecular weight analysis 有权

    公开(公告)号：US12216082B2

    公开(公告)日：2025-02-04

    申请号：US18345798

    申请日：2023-06-30

    Applicant: ProteinSimple

    Inventor： David J. Roach ,  Tom Weisan Yang ,  Hui Xu

    IPC: G01N27/447 ,  G01N21/05 ,  G01N30/74

    Abstract: A system includes a housing, a cartridge retainer disposed within the housing, a detection assembly disposed within the housing, and a reagent tray holder movably disposed in the housing. The cartridge retainer configured to receive a capillary cartridge having a capillary. The detection assembly includes at least one emitter, a first detector, and a second detector. The detection assembly is configured to transition between a first configuration, in which the first detector detects a first output of the at least one emitter, and a second configuration, in which the second detector detects a second output of the at least one emitter. The reagent tray holder is configured to move relative to the cartridge retainer to place the capillary of the capillary cartridge in fluid communication with a reagent volume.

    Semiconductor nanosensing device with multilayer graphene sheet for sequencing or sensing nucleic acids
    6.
    发明授权
    Semiconductor nanosensing device with multilayer graphene sheet for sequencing or sensing nucleic acids 有权

    公开(公告)号：US12181460B2

    公开(公告)日：2024-12-31

    申请号：US18039209

    申请日：2021-11-29

    Applicant: Gentroma Inc.

    Inventor： Krista Fretes

    IPC: G01N27/327 ,  B82Y5/00 ,  B82Y30/00 ,  G01N33/487 ,  G01N27/447

    Abstract: A nanosensing device is disclosed for high throughput nucleic acid sequencing or sensing. The device is a silicon chip, having a silicon nitride top layer, an opening through the chip, a hole in the top layer, and a graphene sheet over the top layer and hole. A graphene layer with a p-type crinkle ruga is placed over the hole, and one of more nanopores in the graphene layer may be provided over the hole. A nucleic acid strand transported to the chip may be translocated through a nanopore and the hole by microfluidic forces. An electrical potential across the nanopores can be measured with a patch clamp amplifier to make nucleobase assignments and sequence the DNA. Alternatively, there are no nanopores and the interaction with the crinkle ruga is used to sense the presence of a nucleic acid polymer.

    Electrophoresis device
    8.
    发明授权
    Electrophoresis device 有权

    公开(公告)号：US12174143B2

    公开(公告)日：2024-12-24

    申请号：US17272698

    申请日：2018-10-29

    Applicant: HITACHI HIGH-TECH CORPORATION

    Inventor： Jin Matsumura ,  Ayaka Okuno ,  Ryusuke Kimura ,  Takashi Anazawa ,  Michiru Fujioka ,  Wataru Sato ,  Taro Nakazawa ,  Motohiro Yamazaki

    IPC: G01N27/447

    Abstract: Provided is an electrophoresis device for enhancing its analysis performance. In order to achieve the task, the electrophoresis device includes a capillary array constituted by a capillary, a capillary head for bundling an end of the capillary, an electrode holder for holding an electrode provided at the other end of the capillary and a detector provided for the capillary, a first heater for heating the capillary, and an irradiation detection unit for irradiating a light to the detector to detect a fluorescence generated from a fluorescence labelled sample in the capillary. The electrophoresis device further includes a second heater for heating the detector.

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