公开(公告)号：US20230166257A1

公开(公告)日：2023-06-01

申请号：US17920881

申请日：2021-04-27

Applicant: INTABIO, LLC

Inventor： Scott Mack ,  Wesley Chang ,  Eric Gwerder ,  Ian Walton ,  Donald Wesley Arnold

IPC: B01L3/00 ,  H01J49/16

CPC classification number: B01L3/502784 ,  B01L3/502776 ,  H01J49/165 ,  B01L2300/12 ,  B01L2300/0867 ,  B01L2200/0636

Abstract: Methods, devices, and systems for performing nebulization of a sample from a fluid channel of a microfluidic device are described. The systems or devices disclosed herein may comprise microfluidic devices that comprise a gas channel used for nebulization of the sample at a fluid outlet of the microfluidic device. In some instances, the disclosed devices may be designed to perform isoelectric focusing followed by further characterization of the separated analytes using electrospray ionization coupled with nebulization to introduce the samples into a mass spectrometer. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.

公开(公告)号：US20250003922A1

公开(公告)日：2025-01-02

申请号：US18698440

申请日：2022-10-04

Applicant: INTABIO, LLC

Inventor： Mariam Elnaggar ,  Spencer Clark ,  Steve Lacy ,  Scott Mack ,  Magdalena Ostrowski

IPC: G01N27/447 ,  G01N30/72

Abstract: Methods, devices, and systems for improving the quality of electrospray ionization mass spectrometer (ESI-MS) data are described, as are methods, devices, and systems for achieving improved correlation between chemical separation data and mass spectrometry data.

公开(公告)号：US12174144B2

公开(公告)日：2024-12-24

申请号：US17963934

申请日：2022-10-11

Applicant: Intabio, LLC

Inventor： Erik Gentalen ,  Steve Lacy ,  Scott Mack ,  Luc Bousse ,  Morten Jensen

IPC: G01N27/447 ,  G01N30/60 ,  G01N30/72 ,  G01N30/86 ,  H01J49/14

Abstract: Methods, devices, and systems for improving the quality of electrospray ionization mass spectrometer (ESI-MS) data are described, as are methods, devices, and systems for achieving improved correlation between chemical separation data and mass spectrometry data.

公开(公告)号：US11285484B2

公开(公告)日：2022-03-29

申请号：US16799387

申请日：2020-02-24

Applicant: Intabio, LLC

Inventor： Erik Gentalen ,  Eric Gwerder ,  Scott Mack

IPC: B01L3/00 ,  G01N27/447

Abstract: Methods, devices, and systems for performing a plurality of isoelectric focusing reactions in parallel are described. In some instances, the disclosed devices may be designed to perform isoelectric focusing or other separation reactions followed by further characterization of the separated analytes using mass spectrometry. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.