公开(公告)号：US11644438B2

公开(公告)日：2023-05-09

申请号：US17168390

申请日：2021-02-05

Applicant: Hitachi High-Tech Corporation

Inventor： Ayaka Okuno ,  Motohiro Yamazaki ,  Taro Nakazawa ,  Mitsuhiro Miyazaki ,  Ryusuke Kimura

IPC: G01N27/447

CPC classification number: G01N27/44708 ,  G01N27/44704

Abstract: A capillary cartridge achieves both improvement of attachability and improvement of heat dissipation performance for realizing short-time analysis. A heat dissipation body is provided between a capillary having a detection unit provided in a part thereof and a plate-like support body that supports the capillary, and temperature increase inside the capillary is suppressed by the heat dissipation body, and thereby, electrophoresis can be performed under a high voltage application condition where the amount of heat increases and analysis time is reduced. In addition, it is possible to redress complexity of an operation by reducing a fixing place at the time of attachment to only a detection unit and an electrode holder by using an integration structure in which the capillary, the supporting body, and the heat radiating body are integrated.

公开(公告)号：US12050198B2

公开(公告)日：2024-07-30

申请号：US17276606

申请日：2019-02-28

Applicant: Hitachi High-Tech Corporation

Inventor： Taro Nakazawa ,  Shuhei Yamamoto ,  Shunichi Kariya ,  Katsuhiro Aritome ,  Ayaka Okuno ,  Ryoji Inaba

IPC: G01N27/447

CPC classification number: G01N27/44721 ,  G01N27/44743

Abstract: Aiming at achievement of timely installation of the cartridge, sequential execution of the pretreatment process in the order of installation of the cartridge, and individual shifting of the process to the electrophoresis process upon completion of the pretreatment process, the electrophoresis device according to the present invention includes a plurality of capillaries each filled with a separation medium, a thermostat chamber for holding the capillaries at a predetermined temperature, an irradiation detector which executes light irradiation and detection in an electrophoresis process using the capillaries, a high voltage power supply unit for voltage application to the capillaries, a liquid feeding mechanism for feeding the separation medium to the capillaries, and an autosampler for conveying containers each holding a reagent or a sample to the capillary. The voltage application to the capillaries by the high voltage power supply unit is controlled for each of the capillaries.

公开(公告)号：US10942147B2

公开(公告)日：2021-03-09

申请号：US15739184

申请日：2015-07-01

Applicant: Hitachi High-Tech Corporation

Inventor： Ayaka Okuno ,  Motohiro Yamazaki ,  Taro Nakazawa ,  Mitsuhiro Miyazaki ,  Ryusuke Kimura

IPC: G01N27/447

Abstract: A capillary cartridge achieves both improvement of attachability and improvement of heat dissipation performance for realizing short-time analysis. A heat dissipation body is provided between a capillary having a detection unit provided in a part thereof and a plate-like support body that supports the capillary, and temperature increase inside the capillary is suppressed by the heat dissipation body, and thereby, electrophoresis can be performed under a high voltage application condition where the amount of heat increases and analysis time is reduced. In addition, it is possible to redress complexity of an operation by reducing a fixing place at the time of attachment to only a detection unit and an electrode holder by using an integration structure in which the capillary, the supporting body, and the heat radiating body are integrated.

公开(公告)号：US12174143B2

公开(公告)日：2024-12-24

申请号：US17272698

申请日：2018-10-29

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Jin Matsumura ,  Ayaka Okuno ,  Ryusuke Kimura ,  Takashi Anazawa ,  Michiru Fujioka ,  Wataru Sato ,  Taro Nakazawa ,  Motohiro Yamazaki

IPC: G01N27/447

Abstract: Provided is an electrophoresis device for enhancing its analysis performance. In order to achieve the task, the electrophoresis device includes a capillary array constituted by a capillary, a capillary head for bundling an end of the capillary, an electrode holder for holding an electrode provided at the other end of the capillary and a detector provided for the capillary, a first heater for heating the capillary, and an irradiation detection unit for irradiating a light to the detector to detect a fluorescence generated from a fluorescence labelled sample in the capillary. The electrophoresis device further includes a second heater for heating the detector.

公开(公告)号：US11125720B2

公开(公告)日：2021-09-21

申请号：US16083780

申请日：2016-03-18

Applicant: Hitachi High-Tech Corporation

Inventor： Taro Nakazawa ,  Motohiro Yamazaki ,  Kenko Uchida ,  Akira Fujii

IPC: G01N27/447

Abstract: A capillary electrophoresis apparatus is disclosed that does not discharge and achieves both compactness and performance even with a part configuration having insufficient spatial distance or creeping distance. This capillary electrophoresis apparatus is provided with a resistance heater for heating capillaries, an electrode holder that holds capillary electrodes and is connected to a high-voltage unit, and a conductive member that at least partially comprises metal and has been grounded to a low potential. The electrode holder and conductive member are in contact with heat-dissipating rubber disposed there between that composes a structure comprising an insulation member. As a result of this configuration, discharge risk is reduced through the reduction of the potential of parts near the high-voltage unit and the slow reduction of the high potential of the high-voltage unit.

公开(公告)号：US12013369B2

公开(公告)日：2024-06-18

申请号：US17406686

申请日：2021-08-19

Applicant: Hitachi High-Tech Corporation

Inventor： Taro Nakazawa ,  Motohiro Yamazaki ,  Kenko Uchida ,  Akira Fujii

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  G01N27/44704 ,  G01N27/44713

Abstract: A capillary electrophoresis apparatus is disclosed that does not discharge and achieves both compactness and performance even with a part configuration having insufficient spatial distance or creeping distance. This capillary electrophoresis apparatus is provided with a resistance heater for heating capillaries, an electrode holder that holds capillary electrodes and is connected to a high-voltage unit, and a conductive member that at least partially comprises metal and has been grounded to a low potential. The electrode holder and conductive member are in contact with heat-dissipating rubber disposed there between that composes a structure comprising an insulation member. As a result of this configuration, discharge risk is reduced through the reduction of the potential of parts near the high-voltage unit and the slow reduction of the high potential of the high-voltage unit.

公开(公告)号：US11644680B2

公开(公告)日：2023-05-09

申请号：US17282396

申请日：2018-10-12

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Takashi Anazawa ,  Ryoji Inaba ,  Shuhei Yamamoto ,  Taro Nakazawa

IPC: G02B27/14 ,  G01N21/64

CPC classification number: G02B27/141 ,  G01N21/6402 ,  G01N21/6486 ,  G01N2021/6439 ,  G01N2021/6463

Abstract: In a right-handed XYZ coordinate system, a dichroic-mirror array of the present disclosure includes a first group in which m (m≥2) dichroic mirrors DA1 to DAm are arranged parallel to each other along a positive direction of an X axis and a second group in which n (n≥2) dichroic mirrors DB1 to DBn are arranged parallel to each other along a negative direction of the X axis. Incident surfaces of the DA1 to DAm and incident surfaces of the DB1 to DBn are perpendicular to an XZ plane. A slope of straight lines with normal lines of the incident surfaces of the DA1 to DAm projected onto the XZ plane are negative, and a slope of straight lines with normal lines of incident surfaces of DB1 to DBn projected onto the XZ plane are positive.

公开(公告)号：US10942121B2

公开(公告)日：2021-03-09

申请号：US16650748

申请日：2018-08-29

Applicant: Hitachi High-Tech Corporation

Inventor： Takashi Anazawa ,  Motohiro Yamazaki ,  Taro Nakazawa ,  Michiru Fujioka

IPC: G01N21/63 ,  G01N21/64

Abstract: In order to avoid crosstalk between images by a simple method, an optical system through which lights emitted from a plurality of light emission points pass, and a measurement unit that measures lights imaged by the optical system are provided, and a midpoint of two arbitrary light emission points among the light emission points is shifted away from a center of the optical system. More specifically, the center of the optical system exists outside a light emission point group consisting of the plurality of the light emission points. With the above configuration, main images and ghost images are separated each other, and thus, it is possible to avoid crosstalk caused by ghosting and to correctly analyze emissions from the plurality of the light emission points.