公开(公告)号：US10942121B2

公开(公告)日：2021-03-09

申请号：US16650748

申请日：2018-08-29

Applicant: Hitachi High-Tech Corporation

Inventor： Takashi Anazawa ,  Motohiro Yamazaki ,  Taro Nakazawa ,  Michiru Fujioka

IPC: G01N21/63 ,  G01N21/64

Abstract: In order to avoid crosstalk between images by a simple method, an optical system through which lights emitted from a plurality of light emission points pass, and a measurement unit that measures lights imaged by the optical system are provided, and a midpoint of two arbitrary light emission points among the light emission points is shifted away from a center of the optical system. More specifically, the center of the optical system exists outside a light emission point group consisting of the plurality of the light emission points. With the above configuration, main images and ghost images are separated each other, and thus, it is possible to avoid crosstalk caused by ghosting and to correctly analyze emissions from the plurality of the light emission points.

公开(公告)号：US12174143B2

公开(公告)日：2024-12-24

申请号：US17272698

申请日：2018-10-29

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Jin Matsumura ,  Ayaka Okuno ,  Ryusuke Kimura ,  Takashi Anazawa ,  Michiru Fujioka ,  Wataru Sato ,  Taro Nakazawa ,  Motohiro Yamazaki

IPC: G01N27/447

Abstract: Provided is an electrophoresis device for enhancing its analysis performance. In order to achieve the task, the electrophoresis device includes a capillary array constituted by a capillary, a capillary head for bundling an end of the capillary, an electrode holder for holding an electrode provided at the other end of the capillary and a detector provided for the capillary, a first heater for heating the capillary, and an irradiation detection unit for irradiating a light to the detector to detect a fluorescence generated from a fluorescence labelled sample in the capillary. The electrophoresis device further includes a second heater for heating the detector.

公开(公告)号：US12064767B2

公开(公告)日：2024-08-20

申请号：US17274279

申请日：2018-10-19

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Michiru Fujioka ,  Sakuichiro Adachi

IPC: B01L3/00 ,  G01N35/08

CPC classification number: B01L3/502792 ,  G01N35/08 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2400/0427

Abstract: To enable taking in a biological sample at a position a predetermined distance away from an EWOD electrode, a biochemical cartridge, including a droplet passage on which a plurality of EWOD electrodes is arranged along a direction in which a sample droplet that is a droplet including a biological sample is transported, the plurality of EWOD electrodes configured to transport the sample droplet, and a sample take-in unit having a predetermined distance from an EWOD electrode at a tail end of the droplet passage, the sample take-in unit being provided at a position at which the biological sample in the sample droplet is taken in. When the biological sample is taken in, the sample take-in unit is located at a position lower than the droplet passage having the EWOD electrode at the tail end, and an area between the droplet passage and the sample take-in unit is smoothly connected.

公开(公告)号：US20210293711A1

公开(公告)日：2021-09-23

申请号：US17263602

申请日：2018-08-02

Applicant: Hitachi High-Tech Corporation

Inventor： Satoshi Takahashi ,  Michiru Fujioka ,  Mikihiro Kobayashi ,  Isao Haraura ,  Takeshi Ooura ,  Motohiro Yamazaki

IPC: G01N21/64 ,  C12Q1/6869 ,  G01N27/447

Abstract: There is a phenomenon where a noise in a spike shape caused by, for example, impurities and a noise peak having a spectrum different from a wavelength spectrum of a labeled fluorescent substance are detected during a capillary electrophoresis. Therefore, the disclosure provides a technique to identify an intensity of the labeled fluorescent substance itself without an effect by a noise fluorescence peak caused by impurities. In the disclosure, a fluorescence intensity property (a fluorescence profile of a noise) common to the noise peaks is set, the noise peak is handled as a fluorescent substance different from the labeled fluorescent substance, and the fluorescent substance and the noise are separated by color converting with the labeled fluorescent substance+the noise fluorescent substance (see FIG. 5).

公开(公告)号：US11371980B2

公开(公告)日：2022-06-28

申请号：US16340995

申请日：2016-10-20

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Michiru Fujioka ,  Yusuke Goto

IPC: C12Q1/6806 ,  G01N33/487 ,  C12Q1/6869 ,  G01N27/447 ,  C12Q1/6839 ,  C12Q1/6832

Abstract: The purpose of the present invention is to provide a method for treating biomolecules and a method for analyzing biomolecules with which it is possible to effectively suppress the clog of nanopores. The present invention is a method for treating biomolecules for analysis in which nanopores are used, wherein the method includes a step for preparing a sample solution that includes ammonium cations represented by a prescribed formula and biomolecules in which at least a portion of the higher-order structure has been fused.

公开(公告)号：US20210316310A1

公开(公告)日：2021-10-14

申请号：US17220166

申请日：2021-04-01

Applicant: Hitachi High-Tech Corporation

Inventor： Naoshi Itabashi ,  Michiru Fujioka ,  Shuhei Yamamoto ,  Yoshimitsu Yanagawa ,  Yusuke Goto

IPC: B01L3/00

Abstract: Provided is a technique for moving all of a droplet from a microchannel in which the droplet have been introduced to another layer.
The droplet transport device of the present disclosure includes a substrate having a through-hole or a recess, a first electrode provided on the substrate along the surface of the substrate and arranged at a position adjacent to the through-hole or the recess, a plurality of second electrodes provided on the substrate along a surface of the substrate and to which a voltage for moving the droplet introduced on the substrate is applied, and a dielectric layer covering the surface of the substrate, the first electrode, and the second electrodes, and a water-repellent film provided on the inner wall surface of the through-hole or the recess, and on the dielectric layer.