公开(公告)号：US20240288451A1

公开(公告)日：2024-08-29

申请号：US18562048

申请日：2022-05-18

申请人： 7905122 CANADA INC.

发明人： John Manioudakis ,  Kim Beauregard ,  Paul Jollez

IPC分类号： G01N33/72 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/52

CPC分类号： G01N33/725 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/528

摘要： A chromogenic absorbent material for hemoglobin and glucose detection in an animal excretion is provided. The chromogenic absorbent material comprises a benzidine-type compound, an organic hydroperoxide, an oxidoreductase, a peroxidase, a pseudoperoxidase or a combination thereof, and a polysaccharide matrix, comprising: from about 10 wt % to about 32.5 wt % chemically or mechanically processed non-functionalized cellulose; from about 25 wt % to about 70 wt % pregelatinized starch (PGS); from 0 wt % to about 20 wt % guar gum; from 0 wt % to about 25 wt % methyl hydroxyethyl cellulose (MHEC); from 0 wt % to about 15 wt % hydroxyethyl cellulose (HEC); and from 0 wt % to about 10 wt % carboxymethyl cellulose (CMC).

公开(公告)号：US12054775B2

公开(公告)日：2024-08-06

申请号：US16897052

申请日：2020-06-09

申请人： The Regents of the University of California

发明人： Mark A. Akeson ,  David W. Deamer ,  William B. Dunbar ,  Kate Lieberman ,  Noah A. Wilson

IPC分类号： C12Q1/6869 ,  C12Q1/54 ,  C12Q1/6874 ,  C25B3/29 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

CPC分类号： C12Q1/6874 ,  C12Q1/54 ,  C12Q1/6869 ,  C25B3/29 ,  G01N27/3278 ,  G01N27/4166 ,  G01N33/48721 ,  C12Q1/6869 ,  C12Q2522/101 ,  C12Q2565/631 ,  C12Q1/6869 ,  C12Q2565/631 ,  C12Q2525/301 ,  C12Q2523/307 ,  C12Q1/6869 ,  C12Q2565/631 ,  C12Q2521/101 ,  C12Q2527/127

摘要： Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

公开(公告)号：US20240158830A1

公开(公告)日：2024-05-16

申请号：US18418062

申请日：2024-01-19

申请人： Edeniq, Inc.

发明人： Prachand SHRESTHA ,  Denmark ANTOLIN

IPC分类号： C12Q1/54 ,  G01N1/28

CPC分类号： C12Q1/54 ,  G01N1/28

摘要： Methods and solutions are disclosed for the quantification of mixed-linkage beta-glucan in plant biomass samples. Improved alkaline pretreatment, enzymatic hydrolysis, and glucose measurement parameters are provided that increase the accuracy, precision, and sensitivity of mixed-linkage beta-glucan assays.

公开(公告)号：US11970738B2

公开(公告)日：2024-04-30

申请号：US17098101

申请日：2020-11-13

申请人： The Regents of the University of California

发明人： Mark A. Akeson ,  David W. Deamer ,  William B. Dunbar ,  Roger Jinteh Arrigo Chen ,  Noah A. Wilson

IPC分类号： C12Q1/6874 ,  C12Q1/54 ,  C12Q1/6869 ,  C25B3/29 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

CPC分类号： C12Q1/6874 ,  C12Q1/54 ,  C12Q1/6869 ,  C25B3/29 ,  G01N27/3278 ,  G01N27/4166 ,  G01N33/48721 ,  C12Q1/6869 ,  C12Q2522/101 ,  C12Q2565/631 ,  C12Q1/6869 ,  C12Q2565/631 ,  C12Q2525/301 ,  C12Q2523/307 ,  C12Q1/6869 ,  C12Q2565/631 ,  C12Q2521/101 ,  C12Q2527/127

摘要： Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

公开(公告)号：US11815448B2

公开(公告)日：2023-11-14

申请号：US16988345

申请日：2020-08-07

申请人： TERUMO KABUSHIKI KAISHA

发明人： Fumihiko Chai ,  Takeyuki Moriuchi

IPC分类号： C07D519/00 ,  C12Q1/54 ,  G01N21/78 ,  G01N21/31 ,  C12N9/02 ,  C12N11/096

CPC分类号： G01N21/31 ,  C07D519/00 ,  C12N9/0004 ,  C12N11/096 ,  C12Q1/54 ,  G01N21/78

摘要： Provided is a means capable of measuring an analyte concentration with high accuracy without requiring fractionation of a biological component. The present invention relates to a method for measuring an analyte concentration in a specimen, including (1) preparing the specimen, (2) mixing a coloring reagent, an oxidoreductase, and a light-scattering adjustment reagent with the specimen to obtain an analysis sample having substantially the same scattered light as the specimen, and (3) measuring the analyte concentration by using the analysis sample.

公开(公告)号：US11781167B2

公开(公告)日：2023-10-10

申请号：US16318912

申请日：2018-03-30

申请人： Kikkoman Corporation

发明人： Yosuke Masakari

IPC分类号： C12Q1/54 ,  C12Q1/32

CPC分类号： C12Q1/54 ,  C12Q1/32 ,  G01N2333/90616

摘要： Provided is a method of continuous glucose monitoring (CGM) comprising using an FAD-GDH. The FAD-GDH is capable of retaining initial activity over a certain period of time. Also provided is a method for screening for an FAD-GDH suitable for use in CGM as well as a CGM device comprising an FAD-GDH.

公开(公告)号：US11486849B2

公开(公告)日：2022-11-01

申请号：US16787434

申请日：2020-02-11

申请人： Trividia Health, Inc.

发明人： Steven V. Leone

IPC分类号： G01N27/327 ,  C12Q1/54 ,  G01N27/22 ,  G01N33/543 ,  G01N27/413 ,  G01N27/416

摘要： The present disclosure provides a system for measuring a property of a sample comprising: a test strip for collecting the sample; a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising: calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a difference identity to generate a sinusoidal signal with an amplitude proportional to the phase difference; and adjusting the measurement of the analyte in the sample using that the calculated interferent impedance measurement.

公开(公告)号：US20220187234A1

公开(公告)日：2022-06-16

申请号：US17680487

申请日：2022-02-25

申请人： Instrumentation Laboratory Company

发明人： Xiaoxian Xu ,  Prasad Pamidi ,  Jose Cervera

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N27/333 ,  G01N33/70 ,  G01N33/96 ,  G01N27/30 ,  C12Q1/54 ,  G01N33/53 ,  G16H10/40 ,  G16B25/30 ,  G06F17/18

摘要： Disclosed are multi-enzyme biosensors that are stable at ambient temperature, and methods of making thereof.

公开(公告)号：US11327042B2

公开(公告)日：2022-05-10

申请号：US16429993

申请日：2019-06-03

申请人： Instrumentation Laboratory Company

发明人： Xiaoxian Xu ,  Prasad Pamidi ,  David Raimondi ,  Ruchika Malhotra ,  Matthew Curley

IPC分类号： G01N33/70 ,  G01N33/96 ,  G01N27/327 ,  C12Q1/00 ,  G01N27/333 ,  G01N27/30 ,  C12Q1/54 ,  G01N33/53 ,  G16H10/40 ,  G16B25/30 ,  G06F17/18 ,  C12Q1/58 ,  G01N33/543 ,  G06F30/331

摘要： The disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving measurement accuracy of electrochemical sensors used for measuring creatinine and creatine.

公开(公告)号：US11311215B2

公开(公告)日：2022-04-26

申请号：US16375752

申请日：2019-04-04

申请人： MEDTRONIC MINIMED, INC.

发明人： Chi-En Lin ,  David Probst ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Melissa Tsang ,  Michael E. Miller ,  Parisa Kamgar

IPC分类号： A61B5/145 ,  A61B5/1486 ,  G01N27/327 ,  C12Q1/54 ,  G01N27/02 ,  A61B5/00 ,  C12Q1/00

摘要： The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.