Compositions, Devices, Systems, and Methods for Using a Nanopore
    2.
    发明申请
    Compositions, Devices, Systems, and Methods for Using a Nanopore 审中-公开
    组合物,器件,系统和使用纳米孔的方法

    公开(公告)号:US20140034517A1

    公开(公告)日:2014-02-06

    申请号:US14056636

    申请日:2013-10-17

    IPC分类号: G01N33/487

    摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

    摘要翻译: 可以检测和控制混合物中单个聚合物的装置和方法被提供于另一种化合物,例如纳米孔中的酶。 所述装置和方法还在反馈控制下或使用由多核苷酸和纳米孔之间的相互作用产生的信号来确定多核苷酸的核苷酸碱基序列(〜> 50Hz)。 本发明特别用于分子生物学,结构生物学,细胞生物学,分子开关,分子电路和分子计算装置及其制造领域。

    Compositions, Devices, Systems, and Methods for Using a Nanopore
    6.
    发明申请
    Compositions, Devices, Systems, and Methods for Using a Nanopore 审中-公开
    组合物,器件,系统和使用纳米孔的方法

    公开(公告)号:US20140346059A1

    公开(公告)日:2014-11-27

    申请号:US14300453

    申请日:2014-06-10

    IPC分类号: C12Q1/68 G01N33/487

    摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

    摘要翻译: 可以检测和控制混合物中单个聚合物的装置和方法被提供于另一种化合物,例如纳米孔中的酶。 所述装置和方法还在反馈控制下或使用由多核苷酸和纳米孔之间的相互作用产生的信号来确定多核苷酸的核苷酸碱基序列(〜> 50Hz)。 本发明特别用于分子生物学,结构生物学,细胞生物学,分子开关,分子电路和分子计算装置及其制造领域。