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公开(公告)号:US20160040230A1
公开(公告)日:2016-02-11
申请号:US14919315
申请日:2015-10-21
发明人: Mark A. Akeson , David W. Deamer , William B. Dunbar , Roger Jinteh Arrigo Chen , Noah A. Wilson
IPC分类号: C12Q1/68 , G01N33/487
CPC分类号: C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
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2.
公开(公告)号:US20140034517A1
公开(公告)日:2014-02-06
申请号:US14056636
申请日:2013-10-17
发明人: Mark A. Akeson , David W. Deamer , William B. Dunbar , Roger Jinteh Arrigo Chen , Noah A. Wilson
IPC分类号: G01N33/487
CPC分类号: C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译: 可以检测和控制混合物中单个聚合物的装置和方法被提供于另一种化合物,例如纳米孔中的酶。 所述装置和方法还在反馈控制下或使用由多核苷酸和纳米孔之间的相互作用产生的信号来确定多核苷酸的核苷酸碱基序列(〜> 50Hz)。 本发明特别用于分子生物学,结构生物学,细胞生物学,分子开关,分子电路和分子计算装置及其制造领域。
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公开(公告)号:US10208342B2
公开(公告)日:2019-02-19
申请号:US15713542
申请日:2017-09-22
IPC分类号: C12P19/34 , C12Q1/6874 , C12Q1/6869 , G01N33/487 , C25B3/10 , C12Q1/54 , G01N27/327 , G01N27/416
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
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公开(公告)号:US20180023137A1
公开(公告)日:2018-01-25
申请号:US15713542
申请日:2017-09-22
IPC分类号: C12Q1/68 , G01N27/327 , C12Q1/54 , C25B3/10 , G01N33/487 , G01N27/416
CPC分类号: C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
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5.
公开(公告)号:US20160209350A1
公开(公告)日:2016-07-21
申请号:US15087734
申请日:2016-03-31
发明人: Mark A. Akeson , David W. Deamer , William B. Dunbar , Roger Jinteh Arrigo Chen , Noah A. Wilson
IPC分类号: G01N27/327 , C12Q1/68 , G01N27/416 , C12Q1/54
CPC分类号: C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译: 可以检测和控制混合物中单个聚合物的装置和方法被提供于另一种化合物,例如纳米孔中的酶。 所述装置和方法还在反馈控制下或使用由多核苷酸和纳米孔之间的相互作用产生的信号来确定多核苷酸的核苷酸碱基序列(〜> 50Hz)。 本发明特别用于分子生物学,结构生物学,细胞生物学,分子开关,分子电路和分子计算装置及其制造领域。
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6.
公开(公告)号:US20140346059A1
公开(公告)日:2014-11-27
申请号:US14300453
申请日:2014-06-10
发明人: Mark A. Akeson , David W. Deamer , William B. Dunbar , Roger Jinteh Arrigo Chen , Noah A. Wilson
IPC分类号: C12Q1/68 , G01N33/487
CPC分类号: C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
摘要翻译: 可以检测和控制混合物中单个聚合物的装置和方法被提供于另一种化合物,例如纳米孔中的酶。 所述装置和方法还在反馈控制下或使用由多核苷酸和纳米孔之间的相互作用产生的信号来确定多核苷酸的核苷酸碱基序列(〜> 50Hz)。 本发明特别用于分子生物学,结构生物学,细胞生物学,分子开关,分子电路和分子计算装置及其制造领域。
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公开(公告)号:US20210189482A1
公开(公告)日:2021-06-24
申请号:US17098101
申请日:2020-11-13
发明人: Mark A. Akeson , David W. Deamer , William B. Dunbar , Roger Jinteh Arrigo Chen , Noah A. Wilson
IPC分类号: C12Q1/6874 , C25B3/29 , C12Q1/6869 , G01N33/487 , C12Q1/54 , G01N27/327 , G01N27/416
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
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公开(公告)号:US20200325535A1
公开(公告)日:2020-10-15
申请号:US16897052
申请日:2020-06-09
IPC分类号: C12Q1/6874 , C12Q1/6869 , G01N33/487 , C25B3/10 , C12Q1/54 , G01N27/327 , G01N27/416
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
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公开(公告)号:US10081835B2
公开(公告)日:2018-09-25
申请号:US14056636
申请日:2013-10-17
发明人: Mark A. Akeson , David W. Deamer , William B. Dunbar , Roger Jinteh Arrigo Chen , Noah A. Wilson
IPC分类号: C12Q1/68 , C12Q1/6874 , C12Q1/6869 , G01N33/487 , C25B3/10 , C12Q1/54 , G01N27/327 , G01N27/416
CPC分类号: C12Q1/6874 , C12Q1/54 , C12Q1/6869 , C25B3/10 , G01N27/3278 , G01N27/4166 , G01N33/48721 , C12Q2522/101 , C12Q2565/631
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
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公开(公告)号:US10344327B2
公开(公告)日:2019-07-09
申请号:US15087734
申请日:2016-03-31
发明人: Mark A. Akeson , David W. Deamer , William B. Dunbar , Roger Jinteh Arrigo Chen , Noah A. Wilson
IPC分类号: C12Q1/54 , C25B3/10 , C12Q1/6869 , C12Q1/6874 , G01N27/327 , G01N27/416 , G01N33/487
摘要: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
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