公开(公告)号：US20240344105A1

公开(公告)日：2024-10-17

申请号：US18448454

申请日：2023-08-11

申请人： The University of Chicago

发明人： Matthew R. Stutz ,  Nick Dylla ,  Eric G. Pamer

IPC分类号： C12Q1/06 ,  C12Q1/10

CPC分类号： C12Q1/06 ,  C12Q1/10 ,  G01N2333/195 ,  G01N2333/24 ,  G01N2800/26 ,  G01N2800/52

摘要： Provided herein are biomarkers associated with mortality in COVID-19 patients. In particular, provided herein are fecal biomarkers that correlate with elevated risk of mortality in subjects suffering from COVID-19 with severe respiratory insufficiency, and methods of treating COVID-19 based thereon.

公开(公告)号：US20240336949A1

公开(公告)日：2024-10-10

申请号：US18628860

申请日：2024-04-08

申请人： BIO-RAD EUROPE GMBH ,  BIO-RAD LABORATORIES, INC.

发明人： CHRISTOPHE QUIRING ,  CHRISTINE FAVIER ,  PATRICE SARFATI ,  JEAN FRANCOIS MOUSCADET ,  RONALD LEBOFSKY ,  REBECCA DIEVART

IPC分类号： C12Q1/06 ,  C12N9/26 ,  C12N9/34 ,  C12N9/38 ,  C12N9/40 ,  C12N9/42 ,  C12N9/48 ,  C12Q1/04

CPC分类号： C12Q1/06 ,  C12N9/2428 ,  C12N9/2445 ,  C12N9/2465 ,  C12N9/2471 ,  C12N9/2474 ,  C12N9/485 ,  C12Q1/04 ,  C12Q1/045 ,  C12Y302/01003 ,  C12Y302/01022 ,  C12Y302/01035 ,  C12Y304/11

摘要： Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.

公开(公告)号：US20240318223A1

公开(公告)日：2024-09-26

申请号：US18274539

申请日：2022-01-28

申请人： Anicom Holdings, Inc.

发明人： Kengo MATSUMOTO ,  Hiroshi SUMI ,  Hiroyuki TAKAHASHI ,  Ryo HORIE

IPC分类号： C12Q1/06

CPC分类号： C12Q1/06

摘要： An object of the invention is to provide a method for predicting and determining obesity in an animal, which is a method for predicting obesity in an animal, including a measurement step of measuring the number of bacterial species belonging to one or more families selected from the group consisting of Streptococcaceae, Ruminococcaceae, Bifidobacteriaceae, Enterococcaceae, Erysipelotrichaceae, Coriobacteriaceae, Prevotellaceae, Coprobacillaceae, and Paraprevotellaceae that are present in the body of the animal or in a sample isolated from the animal.

公开(公告)号：US12089916B2

公开(公告)日：2024-09-17

申请号：US16827807

申请日：2020-03-24

申请人： BIORA THERAPEUTICS, INC.

发明人： Sharat Singh ,  Mitchell Lawrence Jones ,  Christopher Loren Wahl

IPC分类号： A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B10/00 ,  A61K45/06 ,  A61K49/00 ,  C12M1/00 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  G01N1/10 ,  G01N1/20 ,  G01N1/38 ,  G01N21/76 ,  G01N33/483 ,  G01N33/487 ,  G01N33/58 ,  A61B5/01 ,  A61B5/03 ,  A61B5/1455

CPC分类号： A61B5/0071 ,  A61B5/073 ,  A61B5/4238 ,  A61B5/4255 ,  A61B5/6861 ,  A61B10/0045 ,  A61K45/06 ,  A61K49/0019 ,  A61K49/0058 ,  C12M29/26 ,  C12N1/20 ,  C12Q1/045 ,  C12Q1/06 ,  C12Q1/10 ,  G01N1/10 ,  G01N1/20 ,  G01N1/38 ,  G01N21/76 ,  G01N33/4833 ,  G01N33/487 ,  G01N33/582 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/036 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/42 ,  A61B10/0038 ,  A61B2010/0061 ,  A61B2010/0074 ,  A61B2562/0233 ,  G01N2001/1031

摘要： The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

公开(公告)号：US20240240227A1

公开(公告)日：2024-07-18

申请号：US18414396

申请日：2024-01-16

申请人： Institute for Environmental Health, Inc.

发明人： Mansour Samadpour

IPC分类号： C12Q1/22 ,  C12Q1/06

CPC分类号： C12Q1/22 ,  C12Q1/06

摘要： Provided are integrated automated systems for quantitative and/or qualitative microbiological assessment and/or analyte assessment of samples using in situ generated culture devices. The systems comprise: an integrated automated system comprising sterile media and/or buffer reagents, culture device parts, and automated components for media and/or buffer handling, test sample handling, culture device assembly, and microbial enumeration and/or detection, all within a sterile environment; and one or more processors; and memory, including computer-executable instructions that, if executed by the one or more processors, cause the integrated automated system to determine that a coded test sample, loaded into the system, is to be quantitatively and/or qualitatively assessed, and accordingly process and microbiologically assess the coded test sample using, for quantitative assessment, one or more specified in situ generated culture devices for quantitative assessment, thereby eliminating the need to sterilize, ship, store, and/or open ex situ fabricated culture devices prior to inoculation thereof.

公开(公告)号：US12039795B2

公开(公告)日：2024-07-16

申请号：US17414191

申请日：2019-12-19

申请人： BD KIESTRA B.V.

发明人： Raphael Rodolphe Marcelpoil

IPC分类号： G06V20/69 ,  C12Q1/06 ,  C12Q1/08 ,  G06T7/194 ,  G06T7/62 ,  G06V10/24 ,  G06V10/50

CPC分类号： G06V20/69 ,  C12Q1/06 ,  C12Q1/08 ,  G06T7/194 ,  G06T7/62 ,  G06V10/24 ,  G06V10/507 ,  G06V20/693 ,  G06V20/695 ,  G06V20/698

摘要： An imaging method for earliest microbial growth detection. The method uses images to determined colony biomass, and the colony biomass determines when the colony can be picked for analysis for identification or antibiotic susceptibility testing. If the sample source is not a pure sample source additional incubation may be required to permit an increase in biomass of the colonies prior to pick.

公开(公告)号：US12031901B2

公开(公告)日：2024-07-09

申请号：US14681777

申请日：2015-04-08

申请人： NCH Corporation

发明人： David Vela ,  Adrian J. Denvir ,  Matthew C Holloway

IPC分类号： G01N17/00 ,  C02F1/50 ,  C12Q1/06 ,  C12Q1/18 ,  G01N21/01 ,  G01N21/17 ,  G01N21/25 ,  G01N21/53 ,  C02F103/02 ,  C12M1/26 ,  F17D1/08 ,  G01N21/27 ,  G01N21/31 ,  G01N21/49 ,  G01N21/64

CPC分类号： G01N17/008 ,  C02F1/50 ,  C12Q1/06 ,  C12Q1/18 ,  G01N21/01 ,  G01N21/17 ,  G01N21/25 ,  G01N21/53 ,  A61M2206/11 ,  C02F2103/023 ,  C02F2303/20 ,  C02F2307/14 ,  C12M1/267 ,  F17D1/08 ,  G01N21/27 ,  G01N2021/3181 ,  G01N21/49 ,  G01N2021/6439

摘要： A system and method for monitoring or detecting a level of biofilm growth in a fluid system and controlling operating parameters of the fluid system based a measured level of growth. The monitoring system and method comprises a dye injection system for periodically injecting dye into a portion of fluid from the fluid system, passing the portion of fluid though a narrow lumen tube to achieve laminar flow and using a light source and optical sensor to detect a transmission or emission indicating a level of biofilm growth in the tube corresponding to a level of growth on components in the fluid system. Information based upon the measurements or calculations made by the monitoring system may be used to manually or automatically alter various operating parameters to control the fluid system and aid in maintaining stable operation of the fluid system within preferred specifications.

公开(公告)号：US11952612B2

公开(公告)日：2024-04-09

申请号：US16349237

申请日：2017-11-13

申请人： Commonwealth Scientific and Industrial Research Organisation

发明人： Helen Dacres ,  Stephen Charles Trowell

IPC分类号： C12Q1/37 ,  C12Q1/06 ,  G01N21/76 ,  G01N33/52

CPC分类号： C12Q1/37 ,  C12Q1/06 ,  G01N21/76 ,  G01N33/52 ,  G01N2333/21

摘要： The present invention relates to sensors and methods for detecting bacterial proteases in a sample. In particular, the present invention relates to sensors and methods for detecting Pseudomonas spp. protease activity in a sample. The sensors and methods may be used to detect or predict spoilage of a dairy product. The invention also relates to methods for preparing samples for protease assays.

公开(公告)号：US11926861B2

公开(公告)日：2024-03-12

申请号：US16779807

申请日：2020-02-03

申请人： Heidi Kay

发明人： Heidi Kay

IPC分类号： C12Q1/06 ,  C12Q1/02

CPC分类号： C12Q1/06 ,  C12Q1/025

摘要： The invention describes a method for determining how to stimulate, monitor and/or inhibit virus production in whole blood culture. The invention relates to a test kit for performing the method and to the use of a suitable blood sampling system. The system can be used to determine how to activate or target latently HIV-infected cells, for clinical management of HIV treatments and for personalized therapeutic strategies.

公开(公告)号：US11898156B2

公开(公告)日：2024-02-13

申请号：US17082008

申请日：2020-10-28

申请人： MD HEALTHCARE INC.

发明人： Yoon-Keun Kim

IPC分类号： C12N15/88 ,  C12Q1/06 ,  C12Q1/686 ,  C12Q1/6886 ,  A61K9/127 ,  A61K35/74 ,  C12N1/20 ,  C12Q1/689 ,  C12R1/01

CPC分类号： C12N15/88 ,  A61K9/1271 ,  A61K35/74 ,  C12N1/20 ,  C12N1/205 ,  C12Q1/06 ,  C12Q1/686 ,  C12Q1/689 ,  C12Q1/6886 ,  C12R2001/01

摘要： The present invention relates to vesicles derived from genus Morganella bacteria and a use thereof, the present inventors experimentally confirmed that the vesicles were significantly decreased in clinical samples derived from patients with a malignant disease such as gastric cancer, colorectal cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer and lymphoma, a cardiovascular disease such as myocardial infarction, cardiomyopathy, atrial fibrillation, variant angina, and stroke, diabetes mellitus, and Parkinson's disease as compared to normal persons, and the vesicles suppressed the secretion of inflammatory mediators by pathogenic vesicles and suppressed the occurrence of cancer, so that the vesicles derived from genus Morganella bacteria may be usefully used for the purpose of developing a method for diagnosing a malignant disease such as gastric cancer, colorectal cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer and lymphoma, a cardiovascular disease such as myocardial infarction, cardiomyopathy, atrial fibrillation, variant angina, and stroke, diabetes mellitus, and Parkinson's disease, and a composition for preventing or treating the diseases or an inflammatory disease.