公开(公告)号：US20240360218A1

公开(公告)日：2024-10-31

申请号：US18592425

申请日：2024-02-29

申请人： KYMAB LIMITED

发明人： Jamie CAMPBELL ,  Nikole SANDY ,  Cassandra VAN KRINKS ,  Stephen John ARKINSTALL ,  Volker GERMASCHEWSKI ,  Ian KIRBY ,  Miha KOSMAC ,  Thomas GALLAGHER ,  Cecilia DEANTONIO ,  Stephen Douglas GILLIES

IPC分类号： C07K16/28 ,  A61K39/00 ,  C07K14/55 ,  C07K16/46 ,  C07K19/00

CPC分类号： C07K16/2827 ,  C07K14/55 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/468 ,  C07K19/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/74

摘要： The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

公开(公告)号：US20240309382A1

公开(公告)日：2024-09-19

申请号：US18660147

申请日：2024-05-09

申请人： Avidity Biosciences, Inc.

发明人： Barbora MALECOVA ,  Rob BURKE ,  David SALA CANO ,  Beatrice Diana DARIMONT

IPC分类号： C12N15/113 ,  A61K31/7125 ,  A61K47/68 ,  A61K48/00 ,  A61P21/00 ,  A61P21/06 ,  C07K16/28 ,  C07K19/00

CPC分类号： C12N15/113 ,  A61K31/7125 ,  A61K47/6807 ,  A61K47/6849 ,  A61K47/6889 ,  A61K48/005 ,  A61P21/00 ,  A61P21/06 ,  C07K16/2881 ,  C07K19/00 ,  C07K2317/55 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/313 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3513 ,  C12N2320/32

摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating Facioscapulohumeral muscular dystrophy.

公开(公告)号：US20240309117A1

公开(公告)日：2024-09-19

申请号：US18593510

申请日：2024-03-01

申请人： CITY UNIVERSITY OF HONG KONG

发明人： Chun Kit KWOK ,  Kun ZHANG

IPC分类号： C07K19/00 ,  C12N15/115

CPC分类号： C07K19/00 ,  C12N15/115 ,  C12N2310/16

摘要： Disclosed herein is an aptamer-peptide conjugate comprising a penetrating moiety and an L-form ribonucleic acid (L-RNA) aptamer linked thereto. According to some embodiments of the present disclosure, the L-RNA aptamer has an alkyne group linked to its 5′ end, and the penetrating moiety comprises a cell-penetrating peptide (CPP), a modified amino acid residue, and a first linker linking the modified amino acid residue to the CPP, in which the side chain of the modified amino acid residue has an azide group, so that the L-RNA aptamer is linked to the penetrating moiety via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.

公开(公告)号：US20240309114A1

公开(公告)日：2024-09-19

申请号：US18548113

申请日：2022-03-10

申请人： Biohaven Therapeutics Ltd.

发明人： Gene M. DUBOWCHIK ,  David SPIEGEL ,  Reese M. CALDWELL

IPC分类号： C07K16/44 ,  A61K39/00 ,  A61K47/54 ,  C07K19/00

CPC分类号： C07K16/44 ,  A61K47/549 ,  C07K19/00 ,  A61K2039/505

摘要： An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and optionally, a linker moiety connecting the glycan-specific IgG antibody moiety and the cellular receptor binding moiety.

公开(公告)号：US20240307548A1

公开(公告)日：2024-09-19

申请号：US18279938

申请日：2022-03-04

申请人： Code Biotherapeutics, Inc. ,  University of Maryland, College Park

发明人： Silvia Muro ,  Niksa Roki ,  Robert Getts

IPC分类号： A61K47/68 ,  A61K9/00 ,  A61K39/00 ,  A61K47/42 ,  C07K16/28 ,  C07K19/00

CPC分类号： A61K47/6807 ,  A61K9/0019 ,  A61K47/42 ,  A61K47/6849 ,  C07K16/2821 ,  C07K19/00 ,  A61K2039/505 ,  C07K2317/40 ,  C07K2317/92 ,  C07K2317/94 ,  C12N2310/3513

摘要： The present disclosure provides antibodies, and fragments thereof, conjugated to an oligonucleotide, wherein the oligonucleotide is not hybridized to a DNA dendrimer, compositions comprising the same, and uses thereof in methods of detection, methods of cell isolation, methods of depletion, methods of diagnosis, and methods of treatment.

公开(公告)号：US12083231B2

公开(公告)日：2024-09-10

申请号：US17715970

申请日：2022-04-08

申请人： Hefei University of Technology

发明人： Bao Zhang ,  Wenjie Liu ,  Han Tao ,  Xiaolong Li ,  Pin Chen ,  Rumeng Wang

IPC分类号： A61K9/51 ,  A23P10/30 ,  B05D1/00 ,  C07K14/465 ,  C07K19/00 ,  C08B30/18 ,  C12P19/04 ,  C12P19/16 ,  C12P21/06

CPC分类号： A61K9/5192 ,  A23P10/30 ,  A61K9/5161 ,  B05D1/007 ,  C07K14/465 ,  C07K19/00 ,  C08B30/18 ,  C12P19/04 ,  C12P19/16 ,  C12P21/06

摘要： The preparation method of a starch-based double-loaded functional nanoparticle includes: performing restrictive hydrolysis treatment on egg high-density lipoprotein using proteases to obtain the polypeptide; performing self-assembling on a mixed system containing the polypeptide and quercetin under the alkaline condition to form a micelle nanoparticle; performing covalent grafting reaction on a mixed system containing the micelle nanoparticle and anthocyanin under the alkaline condition to form a graft; and electrostatically compounding carboxymethyl dextrin with the graft to obtain the starch-based double-loaded functional nanoparticle. In the preparation method, raw materials derived from natural sources are used, and the self-assembled colloid nanoparticle with good properties can be obtained by adjusting the pH without any organic reagents. The obtained product has a nanoparticle size, has high antioxidant activity and stability against environmental stress, and can be widely applied to the fields of delivery of nutrients, stabilization of biologically active substances and the like.

公开(公告)号：US20240279272A1

公开(公告)日：2024-08-22

申请号：US18438790

申请日：2024-02-12

申请人： Impact Proteomics ,  University of Pittsburgh Medical Center

发明人： Jonathan Minden ,  Dana Ascherman

IPC分类号： C07K1/22 ,  C07K17/00 ,  C07K19/00 ,  C12N9/76

CPC分类号： C07K1/22 ,  C07K17/00 ,  C07K19/00 ,  C12N9/6427 ,  C12Y304/21004

摘要： Materials and methods for isolating self-antigen polypeptides are provided.

公开(公告)号：US12049651B2

公开(公告)日：2024-07-30

申请号：US17555974

申请日：2021-12-20

申请人： Editas Medicine, Inc.

发明人： Cecilia Cotta-Ramusino ,  Hariharan Jayaram ,  John Anthony Zuris

IPC分类号： C12N9/22 ,  C07K19/00 ,  C12N15/10 ,  C12N15/11 ,  C12N15/63 ,  C12N15/90

CPC分类号： C12N9/22 ,  C07K19/00 ,  C12N15/10 ,  C12N15/102 ,  C12N15/11 ,  C12N15/63 ,  C12N15/907 ,  C12Y301/00 ,  C07K2319/80 ,  C12N2310/20 ,  C12N2800/80

摘要： Disclosed herein are enzymatically active Cas9 (eaCas9) fusion molecules, comprising an eaCas9 molecule linked, e.g., covalently or non-covalently, to a template nucleic acid; gene editing systems comprising the eaCas9 fusion molecules, and methods of use thereof.

公开(公告)号：US20240209119A1

公开(公告)日：2024-06-27

申请号：US18577462

申请日：2022-07-08

申请人： DYNE THERAPEUTICS, INC.

发明人： Cody A. Desjardins ,  Kim Tang ,  James McSwiggen ,  Romesh R. Subramanian ,  Timothy Weeden ,  Mohammed T. Qatanani ,  Brendan Quinn ,  John Najim

IPC分类号： C07K19/00 ,  A61K48/00 ,  C07K16/28 ,  C12N15/113

CPC分类号： C07K19/00 ,  A61K48/0058 ,  C07K16/2881 ,  C12N15/113 ,  C12N2310/314 ,  C12N2310/3233

摘要： Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular pay load. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload promotes the expression or activity of a functional dystrophin protein. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide. e.g., an oligonucleotide that causes exon skipping in a mRNA expressed from a mutant DMD allele.

公开(公告)号：US11999955B2

公开(公告)日：2024-06-04

申请号：US18052898

申请日：2022-11-04

申请人： Avidity Biosciences, Inc.

发明人： Barbora Malecova ,  Rob Burke ,  David Sala Cano ,  Beatrice Diana Darimont

IPC分类号： C12N15/113 ,  A61K31/7125 ,  A61K47/68 ,  A61K48/00 ,  A61P21/00 ,  A61P21/06 ,  C07K16/28 ,  C07K19/00

CPC分类号： C12N15/113 ,  A61K31/7125 ,  A61K47/6807 ,  A61K47/6849 ,  A61K47/6889 ,  A61K48/005 ,  A61P21/00 ,  A61P21/06 ,  C07K16/2881 ,  C07K19/00 ,  C07K2317/55 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/313 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3513 ,  C12N2320/32

摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating Facioscapulohumeral muscular dystrophy.