公开(公告)号：US20240400707A1

公开(公告)日：2024-12-05

申请号：US18809215

申请日：2024-08-19

Applicant: Avidity Biosciences, Inc.

Inventor： Barbora MALECOVA ,  Rob BURKE ,  Beatrice Diana DARIMONT ,  David SALA CANO

IPC: C07K16/28 ,  A61K39/00 ,  A61P21/00 ,  C12N15/113

Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating facioscapulohumeral muscular dystrophy (FSHD).

公开(公告)号：US12157774B2

公开(公告)日：2024-12-03

申请号：US18402604

申请日：2024-01-02

Applicant: Avidity Biosciences, Inc.

Inventor： Barbora Malecova ,  Rob Burke ,  Beatrice Diana Darimont ,  David Sala Cano

IPC: C07K16/28 ,  A61P21/00 ,  C12N15/113 ,  A61K39/00

Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating facioscapulohumeral muscular dystrophy (FSHD).

公开(公告)号：US20240287522A1

公开(公告)日：2024-08-29

申请号：US18637337

申请日：2024-04-16

Applicant: Avidity Biosciences, Inc.

Inventor： Barbora MALECOVA ,  Rob BURKE ,  David SALA CANO ,  Beatrice Diana DARIMONT

IPC: C12N15/113 ,  A61K31/7125 ,  A61K47/68 ,  A61K48/00 ,  A61P21/00 ,  A61P21/06 ,  C07K16/28 ,  C07K19/00

CPC classification number: C12N15/113 ,  A61K31/7125 ,  A61K47/6807 ,  A61K47/6849 ,  A61K47/6889 ,  A61K48/005 ,  A61P21/00 ,  A61P21/06 ,  C07K16/2881 ,  C07K19/00 ,  C07K2317/55 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/313 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3513 ,  C12N2320/32

Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating Facioscapulohumeral muscular dystrophy.

公开(公告)号：US20240228646A9

公开(公告)日：2024-07-11

申请号：US18489583

申请日：2023-10-18

Applicant: Avidity Biosciences, Inc.

Inventor： Beatrice Diana DARIMONT ,  Venkata Ramana DOPPALAPUDI ,  Rachel JOHNS

IPC: C07K16/28 ,  A61K47/68

CPC classification number: C07K16/2881 ,  A61K47/6811 ,  A61K47/6849 ,  A61K2039/505

Abstract: Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.

公开(公告)号：US20240132611A1

公开(公告)日：2024-04-25

申请号：US18489583

申请日：2023-10-17

Applicant: Avidity Biosciences, Inc.

Inventor： Beatrice Diana DARIMONT ,  Venkata Ramana DOPPALAPUDI ,  Rachel JOHNS

IPC: C07K16/28 ,  A61K47/68

CPC classification number: C07K16/2881 ,  A61K47/6811 ,  A61K47/6849 ,  A61K2039/505

Abstract: Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.

公开(公告)号：US11912779B2

公开(公告)日：2024-02-27

申请号：US17932653

申请日：2022-09-15

Applicant: Avidity Biosciences, Inc.

Inventor： Barbora Malecova ,  Rob Burke ,  Beatrice Diana Darimont ,  David Sala Cano

IPC: C07K16/28 ,  A61P21/00 ,  C12N15/113 ,  A61K39/00

CPC classification number: C07K16/2881 ,  A61P21/00 ,  C12N15/113 ,  A61K2039/505 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321

Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating facioscapulohumeral muscular dystrophy (FSHD).

公开(公告)号：US11834510B2

公开(公告)日：2023-12-05

申请号：US17243362

申请日：2021-04-28

Applicant: Avidity Biosciences, Inc.

Inventor： Beatrice Diana Darimont ,  Venkata Ramana Doppalapudi ,  Rachel Johns

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/2881 ,  A61K47/6811 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565

Abstract: Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.

公开(公告)号：US20220324984A1

公开(公告)日：2022-10-13

申请号：US17308888

申请日：2021-05-05

Applicant: Avidity Biosciences, Inc.

Inventor： Andrew John GEALL ,  Venkata Ramana DOPPALAPUDI ,  David Sai-Ho CHU ,  Michael Caramian COCHRAN ,  Rachel Elizabeth JOHNS ,  Palani BALU ,  Rob BURKE ,  Beatrice Diana DARIMONT

IPC: C07K16/28 ,  A61K31/713 ,  A61P35/02 ,  A61K47/68 ,  C12N15/113 ,  C07K16/30 ,  A61K31/7088 ,  A61K48/00 ,  A61P35/00 ,  C12N15/88 ,  A61K47/60

Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

公开(公告)号：US20220096647A1

公开(公告)日：2022-03-31

申请号：US17499800

申请日：2021-10-12

Applicant: Avidity Biosciences, Inc.

Inventor： Andrew John GEALL ,  Venkata Ramana DOPPALAPUDI ,  David Sai-Ho CHU ,  Michael Caramian COCHRAN ,  Michael HOOD ,  Beatrice Diana DARIMONT ,  Rob BURKE ,  Yunyu SHI ,  Gulin Erdogan MARELIUS ,  Barbora MALECOVA

IPC: A61K47/68 ,  A61K31/712 ,  A61K31/713 ,  C07K16/18 ,  C12N15/113 ,  A61P21/00 ,  A61K39/395

Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.

公开(公告)号：US20220033434A1

公开(公告)日：2022-02-03

申请号：US17507669

申请日：2021-10-21

Applicant: Avidity Biosciences, Inc.

Inventor： Beatrice Diana DARIMONT

IPC: C07H21/02 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/50 ,  C12N15/113 ,  C12N15/87

Abstract: Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against androgen receptor. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against androgen receptor.