公开(公告)号：US20240309114A1

公开(公告)日：2024-09-19

申请号：US18548113

申请日：2022-03-10

申请人： Biohaven Therapeutics Ltd.

发明人： Gene M. DUBOWCHIK ,  David SPIEGEL ,  Reese M. CALDWELL

IPC分类号： C07K16/44 ,  A61K39/00 ,  A61K47/54 ,  C07K19/00

CPC分类号： C07K16/44 ,  A61K47/549 ,  C07K19/00 ,  A61K2039/505

摘要： An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and optionally, a linker moiety connecting the glycan-specific IgG antibody moiety and the cellular receptor binding moiety.