公开(公告)号：US12043611B2

公开(公告)日：2024-07-23

申请号：US17019817

申请日：2020-09-14

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Jian Li ,  Liang Huang ,  Tyler Fleetham

IPC分类号： C07D401/14 ,  C07F1/12 ,  C07F7/08 ,  C07F9/50 ,  C07F15/00 ,  C09K11/06 ,  H10K50/00 ,  H10K85/30 ,  H10K85/60 ,  H10K50/11 ,  H10K101/10

CPC分类号： C07D401/14 ,  C07F1/12 ,  C07F7/0803 ,  C07F9/5045 ,  C07F15/0033 ,  C07F15/006 ,  C07F15/0073 ,  C09K11/06 ,  H10K50/00 ,  H10K85/341 ,  H10K85/654 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/1074 ,  C09K2211/1096 ,  C09K2211/18 ,  C09K2211/185 ,  H10K50/11 ,  H10K85/324 ,  H10K2101/10 ,  Y02E10/549

摘要： Complexes and devices, such as organic light emitting devices and full color displays, including a compound of the formula:






wherein:
M is Pd2+, Ir+, Rh+, or Au3+;
each of V1, V2, V3, and V4 is coordinated to M and is independently N, C, P, B, or Si;
each of L1, L2, L3, and L4 is independently a substituted or unsubstituted aryl, cycloalkyl, cycloalkenyl, heterocyclyl, heteroaryl, carbene, or N-heterocyclic carbene; and
Z is O, S, NR, CR2, SiR2, BR, PR,










 where each R is independently substituted or unsubstituted C1-C4 alkyl or substituted or unsubstituted aryl.

公开(公告)号：US12012426B2

公开(公告)日：2024-06-18

申请号：US18120855

申请日：2023-03-13

申请人： Takasago International Corporation

发明人： Shigeru Funane

IPC分类号： C07F9/50 ,  B01J31/24

CPC分类号： C07F9/5022 ,  B01J31/24 ,  C07F9/5013 ,  C07F9/5018 ,  B01J2531/0255 ,  B01J2531/821

摘要： The present invention relates to a transition metal complex having a PNNP4 ligand, which is easy to manufacture and handle and is relatively inexpensively available, and a method for manufacturing the same, as well as a method using this transition metal complex as a catalyst for hydrogenation reduction of ketones, esters and amides to manufacture corresponding alcohols, aldehydes, hemiacetals and hemiaminals, a method using this transition metal complex as a catalyst for oxidation of alcohols, hemiacetals and hemiaminals to manufacture corresponding carbonyl compounds, and a method using this transition metal complex as a catalyst for dehydrogenation condensation between alcohols and amines to manufacture alkylamines.

公开(公告)号：US20240189322A1

公开(公告)日：2024-06-13

申请号：US18516091

申请日：2023-11-21

申请人： Genzyme Corporation

发明人： John L. KANE, JR. ,  Gloria MATTHEWS ,  Markus METZ ,  Michael KOTHE ,  Jinyu LIU ,  Andrew SCHOLTE

IPC分类号： A61K31/551 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D519/00 ,  C07F9/50 ,  C07F9/6506 ,  C07F9/6558 ,  C07F9/6561

CPC分类号： A61K31/551 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D519/00 ,  C07F9/5022 ,  C07F9/6506 ,  C07F9/65583 ,  C07F9/6561

摘要： Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune disease, defects of bone metabolism and/or cancer, and are particularly useful in the treatment of osteoarthritis (OA), pain, and pain associated with OA. Trk inhibitors are also useful for inhibiting tropomyosin-related kinase A (TrkA), tropomyosin-related kinase B (TrkB), tropomyosin-related kinase C (TrkC), and/or c-FMS (the cellular receptor for colony stimulating factor-1 (CSF-1)).

公开(公告)号：US11740233B2

公开(公告)日：2023-08-29

申请号：US16014965

申请日：2018-06-21

申请人： Ventana Medical Systems, Inc.

发明人： Julia Ashworth-Sharpe ,  Christopher Bieniarz ,  Michael Farrell ,  Donald D. Johnson ,  Jerome W. Kosmeder ,  Adrian E. Murillo ,  Chol Steven Yun ,  Zhanna Zhilina

IPC分类号： G01N33/543 ,  G01N33/531 ,  G01N33/68 ,  G01N33/553 ,  C07F9/12 ,  C07F9/50 ,  C07F9/572 ,  C07F9/655 ,  G01N33/58

CPC分类号： G01N33/54346 ,  C07F9/12 ,  C07F9/5004 ,  C07F9/5022 ,  C07F9/5045 ,  C07F9/5728 ,  C07F9/65515 ,  C07F9/65517 ,  C07F9/65522 ,  G01N33/531 ,  G01N33/553 ,  G01N33/587 ,  G01N33/6854 ,  G01N2333/916

摘要： Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.

公开(公告)号：US20230243068A1

公开(公告)日：2023-08-03

申请号：US18131255

申请日：2023-04-05

申请人： Applied Materials, Inc.

发明人： Errol Antonio C. SANCHEZ ,  Mark J. SALY ,  Schubert CHU ,  Abhishek DUBE ,  Srividya NATARAJAN

IPC分类号： C30B29/54 ,  H01L21/02 ,  C07F9/50 ,  C30B25/02 ,  H01L29/08

CPC分类号： C30B29/54 ,  H01L21/02521 ,  C07F9/5009 ,  C30B25/02 ,  H01L21/0262 ,  H01L29/0843

摘要： Embodiments generally relate to methods for depositing silicon-phosphorous materials, and more specifically, relate to using silicon-phosphorous compounds in vapor deposition processes (e.g., epitaxy, CVD, or ALD) to deposit silicon-phosphorous materials. In one or more embodiments, a method for forming a silicon-phosphorous material on a substrate is provided and includes exposing the substrate to a deposition gas containing one or more silicon-phosphorous compounds during a deposition process and depositing a film containing the silicon-phosphorous material on the substrate. The silicon-phosphorous compound has the chemical formula [(R3-vHvSi)—(R2-wHwSi)n]xPHyR′z, where each instance of R and each instance of R′ are independently an alkyl or a halogen, n is 0, 1, or 2; v is 0, 1, 2, or 3; w is 0, 1, or 2; x is 1, 2, or 3; y is 0, 1, or 2; z is 0, 1, or 2, and where x+y+z=3.

公开(公告)号：US20230219072A1

公开(公告)日：2023-07-13

申请号：US18180213

申请日：2023-03-08

申请人： EVONIK OPERATIONS GMBH

发明人： Ji YANG ,  Ralf JACKSTELL ,  Matthias BELLER ,  Robert FRANKE

IPC分类号： B01J31/24 ,  B01J31/18 ,  C07F9/50

CPC分类号： B01J31/2409 ,  B01J31/1815 ,  C07F9/5045 ,  B01J2231/321 ,  B01J2531/004 ,  B01J2531/828

摘要： Platinum complexes having benzyl-based diphosphine ligands for the catalysis of the alkoxycarbonylation of ethylenically unsaturated compounds.

公开(公告)号：US20230174563A1

公开(公告)日：2023-06-08

申请号：US17983662

申请日：2022-11-09

申请人： The Government of the United States of America, as represented by the Secretary of the Navy

发明人： Brian L. Chaloux ,  Andrew P. Purdy ,  Albert Epshteyn

IPC分类号： C07F9/50

CPC分类号： C07F9/5036

摘要： Cyanophosphines other than P(CN)3 react with lithium dicyanamide to produce lithiated carbon phosphonitrides with mobile Li+ ions.

公开(公告)号：US20230151035A1

公开(公告)日：2023-05-18

申请号：US17783648

申请日：2020-12-17

申请人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

发明人： Qilin ZHOU ,  Fenghua ZHANG ,  Jianhua XIE ,  Lixin WANG

IPC分类号： C07F9/50 ,  C07F15/00 ,  B01J31/24

CPC分类号： C07F9/5022 ,  C07F15/004 ,  B01J31/2409 ,  C07B53/00

摘要： The present invention relates to a preparation method for and an application of a chiral spirocyclic phosphine-nitrogen-phosphine tridentate ligand SpiroPNP and an iridium catalyst Ir-SpiroPNP thereof. The chiral spirocyclic phosphine-nitrogen-phosphine tridentate ligand is a compound represented by formula I, or a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and the main structural feature is a phosphine ligand having a chiral spiro indene skeleton and a large sterically hindered substituent. The chiral spirocyclic phosphine-nitrogen-phosphine tridentate ligand can be synthesized into a chiral starting material from a 7-diaryl/alkylphosphino-7′-amino-1,1′-spirodihydroindenyl compound having a spiro ring skeleton. The iridium catalyst of the chiral spirocyclic phosphino-7′-amino-1,1′-spirodihydroindenyl compound having a sprio ring skeleton. The iridium catalyst of the chiral spirocyclic phosphine-nitrogen-phosphine tridentate ligand is a compound represented by formula II, or a racemate or optical isomer thereof, or a catalytically acceptable salt thereof. The iridium catalyst can be used to catalyze the asymmetric catalytic hydrogenation of carbonyl compounds, and especially in the asymmetric catalytic hydrogenation of simple dialkyl ketones. Said catalyst exhibits high yield (>99%) and enantioselectivity (up to 99.8% ee), thus having practical value.

公开(公告)号：US11596934B2

公开(公告)日：2023-03-07

申请号：US17165636

申请日：2021-02-02

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Yunho Lee ,  Changho Yoo ,  Jonghoon Choi

IPC分类号： B01J31/24 ,  C07F9/50 ,  C07F15/04 ,  C07F9/64 ,  C07F15/00 ,  C07F15/02 ,  C07F15/06

摘要： Disclosed are a pincer-type ligand having a structurally rigid acridane structure and a metal complex consisting of the pincer-type ligand and a metal bound to each other, and exhibiting high reactivity and stability during a variety of bonding activation reactions. T-shaped complexes can be prepared from acriPNP(4,5-bis(diisopropylphosphino)-2,7,9,9-tetramethyl-9H-acridin-10-ide), which is a pincer-type PNP ligand having an acridane structure, and metal complexes, which can be structurally rigid and thus exhibit excellent reactivity and stability based on minimized structural change thereof, can be prepared by introducing an acridane structure into the backbone thereof. The PNP ligand is structurally stable and has novel chemical properties, as compared to conventional similar ligands, and thus can be utilized in a wide range of catalytic reactions and material chemistry.

公开(公告)号：US11564394B2

公开(公告)日：2023-01-31

申请号：US17118328

申请日：2020-12-10

申请人： University of Kentucky Research Foundation

发明人： Sylvie Garneau-Tsodikova ,  Emily K Dennis ,  Jong Hyun Kim ,  Samuel G. Awuah

IPC分类号： A01N57/36 ,  C07F9/50 ,  C07F9/6568

摘要： The presently-disclosed subject matter describes distorted gold (I) phosphine compounds. The presently-disclosed subject matter also describes a method for killing fungus comprising contacting fungus with distorted gold (I) phosphine compounds. The presently-disclosed subject matter further describes a method of preventing or disrupting a biofilm on a surface comprising contacting a surface with distorted gold (I) phosphine compounds.