Metal-Organic Frameworks with Pyrazole-Based Building Blocks

    公开(公告)号:US20240309022A1

    公开(公告)日:2024-09-19

    申请号:US18571305

    申请日:2022-06-21

    申请人: BASF SE

    IPC分类号: C07F3/06 C01B37/00 C05G3/90

    CPC分类号: C07F3/06 C01B37/00 C05G3/90

    摘要: The present invention relates to a metal-organic framework comprising (i) at least one metal M selected from the group consisting of Na, K, Ca, Mg, Zn, Fe, Mn, Cu, Al, Ni, and Mo in cationic form; and at least one substituted pyrazolate compound of formula (I). Further, the present invention relates to the use of the metal-organic framework of the invention and methods of applying the metal-organic framework of the invention for reducing nitrification. Moreover, the present invention relates to agrochemical mixtures and compositions comprising the metal-organic framework of the invention as well as to a method of treating a fertilizer comprising the application of a metal-organic framework of the invention.

    Zinc complex, preparation thereof and use thereof for trerapy of human and animal diseases

    公开(公告)号:US12077551B2

    公开(公告)日:2024-09-03

    申请号:US17270384

    申请日:2019-08-22

    IPC分类号: C07F3/06 A61P17/00

    CPC分类号: C07F3/06 A61P17/00

    摘要: The invention relates to a new zinc complex with gamma-L-glutamylhistamine with a metal/ligand ratio of 1/1. In particular, the invention relates to a compound of the formula




    The complex according to the invention helps to restore the barrier functions of the epithelial tissue and suppresses the aberrant activity of the immune cells.
    The invention also relates to the method of complex preparation and use of said zinc complex for the treatment of atopic dermatitis and other diseases associated with impaired barrier functions of epithelial tissue and the development of an aberrant inflammatory response.
    The invention also relates to the use of the prepared complex for inhibiting glutaminyl cyclase.
    This invention also concerns pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention.

    Light-stimuli responsive coordination polymer, and preparation and use thereof

    公开(公告)号:US11976087B2

    公开(公告)日:2024-05-07

    申请号:US18026820

    申请日:2022-02-15

    摘要: The invention provides a light-stimuli responsive coordination polymer, and preparation method and use thereof. The coordination polymer has a chemical formula of [Zn(tkpvb) (Fb)2]n1, wherein Fb represents p-fluorobenzoate, tkpvb represents 1,2,4,5-tetrakis((E)-2-(4-pyridyl)vinyl)benzene, and n=3000-60000; and crystallographic parameters of: (1) crystal system: monoclinic system; (2) space group: C2/c; (3) a=28.577(3)Å, b=7.4084(6) Å, c=22.612(3) Å, β=126.771(2)°, and V=3834.8(7) Å3; (4) Z=4; and (5) F(000)=1720, R1=0.0440, wR2=0.1042, and GOF=1.047. The method is simple, and has mild reaction conditions, and fast light conversion rate. The means of light-stimuli responsiveness are non-contact and non-damage type, the volume adjustment is highly accurate, and the whole adjustment process does not require any chemical reagents, and is safe and reliable. Photoactuators can complete a variety of behaviors under the irradiation of ultraviolet light having a wavelength of 365 nm.