公开(公告)号：US20240409508A1

公开(公告)日：2024-12-12

申请号：US18742992

申请日：2024-06-13

Applicant: OrsoBio, Inc.

Inventor： Julie FARAND ,  Joshua A. KAPLAN ,  Gregory NOTTE ,  Casey Lockwood OLEN ,  Michael SANGI ,  David SPERANDIO

IPC: C07C323/25 ,  A61K31/18 ,  A61P1/16 ,  C07C311/08 ,  C07C311/13 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07C311/39 ,  C07C311/46 ,  C07C313/06 ,  C07C323/30 ,  C07C323/31 ,  C07D205/04 ,  C07D207/48 ,  C07D213/89 ,  C07D231/18 ,  C07D235/00 ,  C07D239/26 ,  C07D257/04 ,  C07D275/02 ,  C07D277/36 ,  C07D279/12 ,  C07D295/116 ,  C07D305/08 ,  C07D309/08 ,  C07D335/02 ,  C07D451/02 ,  C07D493/08 ,  C07F9/50

Abstract: Provided is a compound of Formula (I): wherein the variable groups are defined herein.

公开(公告)号：US11939421B2

公开(公告)日：2024-03-26

申请号：US17267889

申请日：2019-08-30

Applicant: HEXCEL COMPOSITES LIMITED

Inventor： Christopher Robert Mason ,  Nicholas Verge

IPC: C08G59/40 ,  C07C257/22 ,  C07D235/00 ,  C07D247/02 ,  C08G59/00 ,  C08G59/68 ,  C08G59/70 ,  C08K5/25 ,  C08K5/544

CPC classification number: C08G59/686 ,  C07C257/22 ,  C07D235/00 ,  C07D247/02 ,  C08G59/00 ,  C08G59/4014 ,  C08G59/4035 ,  C08G59/70 ,  C08K5/25 ,  C08K5/5477

Abstract: A curative system comprising a combination of adipic acid dihydrazide and/or isophthalic dihydrazide and a clathrate in which the guest compound of the clathrate comprises an imidazole, an imidazoline or diazabicycloalkanes (DBCA).

公开(公告)号：US11608329B2

公开(公告)日：2023-03-21

申请号：US17126279

申请日：2020-12-18

Applicant: Ikena Oncology, Inc.

Inventor： Alfredo C. Castro ,  Karen J. McGovern ,  Michael Burke

IPC: C07D277/42 ,  C07D417/04 ,  A61P1/00 ,  A61P29/00 ,  C07D235/00 ,  C07D249/14 ,  C07D263/48 ,  C07D271/07 ,  C07D271/113 ,  C07D277/48 ,  C07D285/135 ,  C07D333/36 ,  C07D417/12

Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.

公开(公告)号：US20200045968A1

公开(公告)日：2020-02-13

申请号：US16496701

申请日：2018-04-10

Applicant: MITSUI CHEMICALS AGRO, INC.

Inventor： Hideki UMETANI ,  Shun OKAYA ,  Hideaki IKISHIMA ,  Takeshi FUKUMOTO ,  Akihiro NISHIDA ,  Masanori YANAGI ,  Ryohei NAITO ,  Koji MASUTOMI ,  Tomomi SHIRAKAWA ,  Akane SAKURADA ,  Satoshi YUTANI

IPC: A01N43/653 ,  A01N43/56 ,  A01N43/40 ,  A01N43/10 ,  C07D333/22 ,  C07D401/04 ,  A01N43/76 ,  C07D203/04 ,  C07D235/00 ,  C07D231/12 ,  C07D249/08 ,  C07D413/04 ,  C07D405/04 ,  C07D409/04 ,  A01N43/50 ,  C07D471/10

Abstract: Pyridine compounds of Formula (1) are provided: wherein R1, R2, X, Y and Het are defined. The pyridine compounds can be used to treat or prevent plant diseases.

公开(公告)号：US09379330B2

公开(公告)日：2016-06-28

申请号：US13805927

申请日：2011-05-30

Applicant: Philipp Stoessel ,  Arne Buesing ,  Dominik Joosten

Inventor： Philipp Stoessel ,  Arne Buesing ,  Dominik Joosten

IPC: H01L51/00 ,  C07D235/00 ,  C07D487/04 ,  C09K11/06 ,  H01L51/50 ,  H05B33/14 ,  B32B9/00

CPC classification number: H01L51/0072 ,  B32B9/00 ,  B32B2457/202 ,  C07D235/00 ,  C07D487/04 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1088 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/0056 ,  H01L51/0058 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0067 ,  H01L51/0071 ,  H01L51/0081 ,  H01L51/0085 ,  H01L51/0094 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5024 ,  H01L51/5056 ,  H01L51/5072 ,  H01L51/5088 ,  H01L51/5096 ,  H05B33/14 ,  Y02E10/549

Abstract: The present invention relates to an electronic device comprising anode, cathode and at least one organic layer which comprises a compound of the formula (I) to (IV). The invention furthermore encompasses the use of compounds of the formula (I) to (IV) in an electronic device and to a compound of the formula (Ic) to (IVc).

Abstract translation: 本发明涉及包含阳极，阴极和至少一个有机层的电子器件，其包含式（I）至（IV）的化合物。 本发明还包括在电子装置中使用式（I）至（IV）的化合物和式（Ic）至（IVc）的化合物。

公开(公告)号：US08987468B2

公开(公告)日：2015-03-24

申请号：US12865903

申请日：2009-02-03

Applicant: Tong Wang ,  Stephen Gately

Inventor： Tong Wang ,  Stephen Gately

IPC: C07D235/00 ,  C07C239/00 ,  C07C259/00 ,  C07D235/16 ,  C07D403/04

CPC classification number: A61K31/506 ,  A61K31/4184 ,  A61K31/437 ,  A61K45/06 ,  C07D235/16 ,  C07D403/04

Abstract: The invention encompasses a compound derived from hydroxamic acid that may be used to slow the expansion of cancer cells and thus is effective in the treatment of cancer. Generally, the disclosed compound includes a benzimidazole group coupled to a hydroxyamide of five or more unsubstituted carbon atoms and any pharmaceutically acceptable salts, solvates and chemically protected forms thereof. Also disclosed are pharmacological compositions including the compound and methods of using the compound to slow the expansion of cancer cells as well as methods of using the compound to treat cancer.

Abstract translation: 本发明包括衍生自异羟肟酸的化合物，其可用于减缓癌细胞的扩增，因此有效治疗癌症。 通常，所公开的化合物包括与五个或更多个未取代的碳原子的羟基酰胺偶联的苯并咪唑基团和其任何药学上可接受的盐，溶剂合物和化学保护形式。 还公开了药物组合物，包括该化合物和使用该化合物减缓癌细胞扩增的方法以及使用该化合物治疗癌症的方法。

公开(公告)号：US08772504B2

公开(公告)日：2014-07-08

申请号：US13144557

申请日：2010-02-15

Applicant: Henricus Jacobus Maria Gijsen ,  François Paul Bischoff ,  Wei Zhuang ,  Sven Franciscus Anna Van Brandt ,  Michel Surkyn ,  Mirko Zaja ,  Didier Jean-Claude Berthelot ,  Michel Anna Jozef De Cleyn ,  Gregor James MacDonald ,  Daniel Oehlrich

Inventor： Henricus Jacobus Maria Gijsen ,  François Paul Bischoff ,  Wei Zhuang ,  Sven Franciscus Anna Van Brandt ,  Michel Surkyn ,  Mirko Zaja ,  Didier Jean-Claude Berthelot ,  Michel Anna Jozef De Cleyn ,  Gregor James MacDonald ,  Daniel Oehlrich

IPC: C07D235/00 ,  C07D403/02

CPC classification number: C07D413/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract translation: 本发明涉及式（I）的新的取代苯并恶唑，苯并咪唑，恶唑并吡啶和咪唑并吡啶衍生物，其中R1，R2，R3，R4，X，A1，A2，A3，A4，Y1，Y2，Y3和Z具有含义 在权利要求中限定。 根据本发明的化合物可用作γ-分泌酶调节剂。 本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。

公开(公告)号：US08754114B2

公开(公告)日：2014-06-17

申请号：US13333021

申请日：2011-12-21

Applicant: Wenqing Yao ,  Colin Zhang ,  Meizhong Xu ,  Jincong Zhuo ,  Chunhong He

Inventor： Wenqing Yao ,  Colin Zhang ,  Meizhong Xu ,  Jincong Zhuo ,  Chunhong He

IPC: A01N43/42 ,  A61K31/415 ,  C07D235/00

CPC classification number: A61K31/5025 ,  A61K31/5377 ,  C07D235/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D487/04

Abstract: The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.

Abstract translation: 本发明涉及取代的咪唑并哒嗪和取代的苯并咪唑，以及含有它们的药物组合物，它们是可用于治疗癌症和其它疾病的FGFR3抑制剂。

公开(公告)号：US08748411B2

公开(公告)日：2014-06-10

申请号：US11920031

申请日：2006-05-05

Applicant: Rolando Eduardo Rodriguez Fernandez ,  Roberto Vera Alvarez ,  Ania De La Nuez Veulens ,  Yuliet Mazola Reyes ,  Silvio Ernesto Perea Rodriguez ,  Boris Ernesto Acevedo Castro ,  Alexis Musacchio Lasa ,  Raimundo Ubieta Gómez

Inventor： Rolando Eduardo Rodriguez Fernandez ,  Roberto Vera Alvarez ,  Ania De La Nuez Veulens ,  Yuliet Mazola Reyes ,  Silvio Ernesto Perea Rodriguez ,  Boris Ernesto Acevedo Castro ,  Alexis Musacchio Lasa ,  Raimundo Ubieta Gómez

IPC: A61K31/66 ,  A61K31/53 ,  A61K31/505 ,  A61K31/47 ,  A61K31/415 ,  A61K31/40 ,  C07D251/42 ,  C07D473/00 ,  C07D239/02 ,  C07D215/38 ,  C07D235/00 ,  C07D233/96 ,  C07D209/14 ,  C07D307/02 ,  C07D229/00 ,  C07F9/02 ,  C07C281/02 ,  C07C273/02 ,  C07C303/00 ,  C07C241/00

CPC classification number: C07C211/14 ,  C07C237/06 ,  C07C237/22 ,  C07C243/28 ,  C07C255/42 ,  C07C257/14 ,  C07C271/22 ,  C07C271/64 ,  C07C275/08 ,  C07C275/16 ,  C07C275/24 ,  C07C281/12 ,  C07C317/28 ,  C07C327/42 ,  C07C337/08 ,  C07D207/34 ,  C07D209/14 ,  C07D213/81 ,  C07D213/82 ,  C07D215/46 ,  C07D233/88 ,  C07D233/91 ,  C07D235/14 ,  C07D239/36 ,  C07D239/46 ,  C07D239/54 ,  C07D251/22 ,  C07D307/52 ,  C07D487/04 ,  C07F9/224

Abstract: Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.

Abstract translation: 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。

公开(公告)号：US08703964B2

公开(公告)日：2014-04-22

申请号：US13793442

申请日：2013-03-11

Applicant: Supratek Pharma Inc.

Inventor： Tomasz Popek ,  Kishore Patel ,  Valery Alakhov ,  Grzegorz Pietrzynski

IPC: C07D235/00 ,  A61K31/415 ,  A01N43/50 ,  A61K31/41

CPC classification number: A61K31/4184 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/38 ,  A61K47/40

Abstract: The present invention is directed to pharmaceutical compositions comprising: (a) bendamustine, (b) a charged cyclopolysaccharide, and (c) a stabilizing agent having a charge opposite to that of the cyclopolysaccharide. Such composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. Such compositions are suitable for injection or infusion into patients in need for treatment with bendamustine.

Abstract translation: 本发明涉及药物组合物，其包含：（a）苯达莫司汀，（b）带电荷的多环多糖，和（c）具有与环多糖相反的电荷的稳定剂。 这样的组合物在诸如血浆的反应性环境中提供了意想不到的期望的稳定性，偶联期望的抗癌活性。 这样的组合物适用于需要用苯达莫司汀治疗的患者的注射或输注。