Use of n-butyllithium for catalyzing hydroboration of imine and borane

    公开(公告)号:US11845068B2

    公开(公告)日:2023-12-19

    申请号:US17225063

    申请日:2021-04-07

    IPC分类号: B01J31/12 C07F5/04

    CPC分类号: B01J31/12 C07F5/04

    摘要: The present invention relates to the use of n-butyllithium for catalyzing the hydroboration of an imine and a borane. A catalyst, the borane and the imine are sequentially stirred and mixed uniformly, and are reacted for 1-2 h; the mixture is exposed to air to terminate the reaction; and the reaction liquid is subjected to reduced pressure to remove the solvent, so as to obtain a borate with different substituents. The n-butyllithium disclosed in the present invention can be used for catalyzing the hydroboration of the imine and the borane in high activity under room temperature conditions, the amount of the catalyst is only 4-5 mol % of the molar weight of the imine, and the yield of the reaction can reach 90% or more.