公开(公告)号：US12116601B2

公开(公告)日：2024-10-15

申请号：US17700598

申请日：2022-03-22

申请人： Novozymes A/S

发明人： Marco Malten ,  Kim Borch ,  Lise Munch Mikkelsen ,  Thomas Agersten Poulsen ,  Luise Erlandsen ,  Hanne Philbert Nielsen ,  Carsten Horslev Hansen ,  Allan Svendsen ,  Christian Lundager Gylstorff ,  Jesper Vind ,  Christian Jackel

IPC分类号： C12N9/18 ,  A61K8/66 ,  B65D65/46 ,  C11D3/386 ,  C11D17/04 ,  C12N9/20

CPC分类号： C12N9/18 ,  A61K8/66 ,  B65D65/46 ,  C11D3/38627 ,  C11D17/042 ,  C11D17/043 ,  C12N9/20 ,  C12Y301/01003 ,  C12Y301/01

摘要： The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning. The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.

公开(公告)号：US12070543B2

公开(公告)日：2024-08-27

申请号：US18323055

申请日：2023-05-24

申请人： Orth Consulting, LLC

发明人： Donald S. Orth ,  Roger W. Orth

IPC分类号： A61M1/36 ,  A61F2/01 ,  A61F2/95 ,  A61K8/66 ,  A61M1/14 ,  A61M1/16 ,  A61M1/26 ,  A61M1/34 ,  B01D15/00 ,  B01D15/08 ,  B01D63/02 ,  B01D63/06 ,  B01D69/04 ,  B01D69/08 ,  B01J20/22 ,  B01J31/00 ,  C07K16/00 ,  C07K16/38 ,  C07K16/40 ,  C12N11/00 ,  C12N11/02 ,  C12N11/06 ,  C12N11/14 ,  C12N11/16 ,  C12N11/18 ,  A61F2/00

CPC分类号： A61M1/3687 ,  A61F2/01 ,  A61F2/95 ,  A61K8/66 ,  A61M1/15632 ,  A61M1/1621 ,  A61M1/267 ,  A61M1/3489 ,  A61M1/36 ,  A61M1/3621 ,  A61M1/3653 ,  A61M1/3679 ,  A61M1/3689 ,  B01D15/00 ,  B01D15/08 ,  B01D63/02 ,  B01D63/06 ,  B01D69/04 ,  B01D69/043 ,  B01D69/08 ,  B01J20/22 ,  B01J31/003 ,  C07K16/00 ,  C07K16/38 ,  C07K16/40 ,  C12N11/00 ,  C12N11/02 ,  C12N11/06 ,  C12N11/14 ,  C12N11/16 ,  C12N11/18 ,  A61F2/00 ,  A61M2202/0445 ,  A61M2202/0456 ,  A61M2202/046 ,  A61M2202/07 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3303 ,  B01J2220/4812 ,  B01J2220/4868

摘要： A detoxification method for treating sepsis, microbial infections, and other inflammatory conditions includes the steps of inducing flow of patient blood through a blood treatment device consisting of a bioreactor inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) and extracellular adenosine triphosphate (ATP) contained within patient blood can be irreversibly detoxified by passage of patient blood over a bioreactor surface having attached or immobilized alkaline phosphatase enzymes and acyloxyacyl hydrolase enzyme, with the bioreactor being contained within the blood treatment device. The method uses continuous treatment of a patient's blood to convert LPS and extracellular ATP in blood into inhibitors of inflammation in vivo without adding any chemicals to the bloodstream of the patient.

公开(公告)号：US12054702B2

公开(公告)日：2024-08-06

申请号：US17150878

申请日：2021-01-15

申请人： DNA TWOPOINTO INC.

发明人： Jeremy Minshull ,  Mark Welch ,  Sridhar Govindrajan ,  Maggie Lee ,  Kate Caves ,  Jon Ness

IPC分类号： C12N9/00 ,  A61K8/66 ,  A61K47/42 ,  C07K14/435 ,  C12N1/16 ,  C12N1/18 ,  C12N9/12 ,  C12N15/10 ,  C12N15/52 ,  C12N15/62 ,  C12N15/63 ,  C12N15/81 ,  C12N15/85 ,  C12N15/90 ,  C12N15/67 ,  C12R1/84 ,  C12R1/865

CPC分类号： C12N1/165 ,  C12N1/185 ,  C12N9/12 ,  C12N9/1241 ,  C12N15/1082 ,  C12N15/52 ,  C12N15/625 ,  C12N15/63 ,  C12N15/81 ,  C12N15/815 ,  C12N15/85 ,  C12N15/8509 ,  C12N15/90 ,  C12Y207/00 ,  C12Y207/07 ,  C07K2319/09 ,  C12N15/67 ,  C12N2800/90 ,  C12N2830/007 ,  C12N2830/40 ,  C12N2830/42 ,  C12N2840/203 ,  C12R2001/84 ,  C12R2001/865

摘要： The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.

公开(公告)号：US20240226250A9

公开(公告)日：2024-07-11

申请号：US18547979

申请日：2022-02-24

申请人： CHONGQING CLARUVIS PHARMACEUTICAL CO., LTD.

发明人： Yan ZHANG

IPC分类号： A61K38/48 ,  A61K8/66 ,  A61Q19/00 ,  C12N9/52

CPC分类号： A61K38/4873 ,  A61K8/66 ,  A61K38/482 ,  A61Q19/00 ,  C12N9/52 ,  C12Y304/22002 ,  C12Y304/24069

摘要： The present invention relates to a modified neurotoxin single-chain polypeptide and a use thereof. The single-chain polypeptide contains a tagged protein, a linker short peptide, etc. The linker short peptide facilitates cleavage of the tagged protein, thereby improving purification of the single-chain polypeptide; in addition, the single-chain polypeptide has neurotoxicity when activated, but the single-chain polypeptide per se is only slightly toxic, such that the production safety is improved and the production process cost is reduced while the yield of the single-chain polypeptide is greatly increased.

公开(公告)号：US12023400B2

公开(公告)日：2024-07-02

申请号：US17314057

申请日：2021-05-07

申请人： Kan Zen Co., Ltd

发明人： Won Sup Choi ,  Hyun Sun Park ,  Da Som Kwon ,  Tae Kyu Park

IPC分类号： A61Q19/08 ,  A61K8/34 ,  A61K8/37 ,  A61K8/64 ,  A61K8/66 ,  C12N9/52

CPC分类号： A61K8/66 ,  A61K8/342 ,  A61K8/375 ,  A61K8/64 ,  A61Q19/08 ,  C12N9/52 ,  C12Y304/24069 ,  C07K2319/033

摘要： Disclosed herein is a recombinant protein including botulinum toxin and cell penetrating peptides and cosmetic composition. The cell penetrating peptide according to the present disclosure may be actively used as a topical agent for various disease treatment, aesthetic, or cosmetic purposes, especially for a cosmetic composition, by securing better convenience as well as maximizing the intrinsic in vivo efficacy of the botulinum toxin through the cell penetrating recombinant proteins that combines the botulinum toxin and a cell penetrating peptide by making skin penetration and/or cell penetration for botulinum toxin more efficient.

公开(公告)号：US20240197589A1

公开(公告)日：2024-06-20

申请号：US18473740

申请日：2023-09-25

申请人： AMERICAN RIVER NUTRITION, LLC

发明人： Barrie TAN ,  Anne TRIAS ,  Jonathan Paul LIZOTTE

IPC分类号： A61K8/34 ,  A61K8/19 ,  A61K8/24 ,  A61K8/35 ,  A61K8/37 ,  A61K8/60 ,  A61K8/66 ,  A61K8/73 ,  A61K8/92 ,  A61K8/9789 ,  A61K8/99 ,  A61L24/00 ,  A61Q11/00

CPC分类号： A61K8/342 ,  A61K8/19 ,  A61K8/24 ,  A61K8/345 ,  A61K8/355 ,  A61K8/37 ,  A61K8/604 ,  A61K8/66 ,  A61K8/731 ,  A61K8/922 ,  A61K8/9789 ,  A61K8/99 ,  A61L24/0015 ,  A61Q11/00 ,  C12Y304/22032 ,  C12Y304/22033 ,  A61K2800/30 ,  A61L2300/216

摘要： The present embodiments relate to oral compositions comprising geranylgeraniol and to methods of using and of making said compositions. The oral compositions can be used in, for example, an oral rinse, a toothpaste, mouth spray, chewing gum, or impregnated in a disposable toothbrush. The compositions can be applied to the gum, alveolar jaw bone, tooth, tooth tissue, enamel, oral cavity, or tooth socket for many uses including, but not limited to, promoting gum growth and gum support, wound healing, and oral hygiene. Additionally, the oral compositions can be used in a dental product, such as a dental gel, gel sponge, or a bone cement, for other uses, including therapeutic uses, such as, but not limited to preventing or treating a jaw-bone related syndrome or disease, promoting wound healing of gum or enamel, and enhanced bone mineralization.

公开(公告)号：US20240108556A1

公开(公告)日：2024-04-04

申请号：US18038550

申请日：2021-11-24

申请人： Topix Pharmaceuticals, Inc.

发明人： Steven M. Hernandez

IPC分类号： A61K8/34 ,  A61K8/66 ,  A61K8/9789 ,  A61P17/02 ,  A61P17/18 ,  A61Q19/00

CPC分类号： A61K8/345 ,  A61K8/66 ,  A61K8/9789 ,  A61P17/02 ,  A61P17/18 ,  A61Q19/00

摘要： Disclosed herein is a topical composition that treats and reduces the visual appearance of a scar through the combination of a hydrophilic occlusion forming agent (e.g., having a water solubility of more than about 75%, such as glycerin) with one or more proteolytic enzymes and an antioxidant system that includes polyphenol antioxidants (e.g., green tea polyphenols). Also disclosed herein are methods of administering the topical compositions described herein for treating and/or reducing the visual appearance of a scar by themselves or as part of a scar treatment regimen in combination with a variety of dermatological procedures. Processes of preparing the topical compositions disclosed herein are also described in certain embodiments.

公开(公告)号：US20240084273A1

公开(公告)日：2024-03-14

申请号：US18451280

申请日：2023-08-17

申请人： Sang Jae Kim ,  GemVax & KAEL CO., LTD.

发明人： Sang Jae KIM

IPC分类号： C12N9/12 ,  A23L33/18 ,  A61K8/64 ,  A61K8/66 ,  A61K47/64 ,  A61K49/00 ,  A61Q19/00 ,  C07K7/08 ,  C07K14/00 ,  G01N33/58

CPC分类号： C12N9/1276 ,  A23L33/18 ,  A61K8/64 ,  A61K8/66 ,  A61K47/64 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0056 ,  A61Q19/00 ,  C07K7/08 ,  C07K14/00 ,  G01N33/582 ,  A61K38/00 ,  C07K2319/10

摘要： The present invention relates to a conjugate of cell penetrating peptide and an active ingredient; and its use. Specifically, a conjugate including a cell penetrating peptide which is a peptide comprising any one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 156, a fragment of any one sequence of SEQ ID NO: 1 to SEQ ID NO: 156, or a peptide having above 80% homology with the above-mentioned sequence; and a composition comprising the same are disclosed.

公开(公告)号：US20240074975A1

公开(公告)日：2024-03-07

申请号：US18272531

申请日：2022-01-24

申请人： EXO LAB ITALIA, S.r.l.

发明人： Mariantonia LOGOZZI ,  Stefano FAIS

IPC分类号： A61K9/127 ,  A61K8/14 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K31/375 ,  A61K36/185 ,  A61K36/22 ,  A61K36/752 ,  A61K38/06 ,  A61K38/44 ,  A61P17/02 ,  A61P39/06 ,  A61Q19/08

CPC分类号： A61K9/127 ,  A61K8/14 ,  A61K8/64 ,  A61K8/66 ,  A61K8/676 ,  A61K31/375 ,  A61K36/185 ,  A61K36/22 ,  A61K36/752 ,  A61K38/063 ,  A61K38/44 ,  A61K38/446 ,  A61P17/02 ,  A61P39/06 ,  A61Q19/08

摘要： Nanovesicles derived from plants of biological origin, comprising a lipid membrane and within the lipid membrane at least one bioavailable antioxidant substance, and use of the same nanovesicles for nutraceutical, cosmetic and regenerative use.

公开(公告)号：US20240041744A1

公开(公告)日：2024-02-08

申请号：US18482998

申请日：2023-10-09

申请人： Endo Ventures Limited

发明人： Jeffrey Davidson ,  Michael McLane ,  Genzhou Liu

IPC分类号： A61K8/66 ,  A61B5/00 ,  A61Q19/06 ,  A61B5/103 ,  A61K38/48

CPC分类号： A61K8/66 ,  C12Y304/24003 ,  A61B5/4848 ,  A61B5/44 ,  A61Q19/06 ,  A61B5/103 ,  A61K38/4886 ,  A61B5/444 ,  A61B5/441 ,  A61B5/1079

摘要： The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.