公开(公告)号：US12128142B2

公开(公告)日：2024-10-29

申请号：US17260952

申请日：2019-07-18

申请人： MEDHERANT LTD

发明人： David Haddleton ,  Gabit Nurumbetov ,  Andrew Ross ,  Vasiliki Nikolaou

IPC分类号： A61K9/70 ,  A61K31/167 ,  A61K31/192 ,  A61K31/465

CPC分类号： A61K9/7069 ,  A61K9/7053 ,  A61K31/167 ,  A61K31/192 ,  A61K31/465

摘要： The invention relates to novel compositions comprising urea and amine functionalised silyl containing polymers which, in combination with tackifying resins, are used as pressure sensitive adhesives and specifically, drug delivery patches. Said compositions can be synthesised with less difficulty compared to urethane analogues and are compatible with a wide array of different drugs.

公开(公告)号：US20240351966A1

公开(公告)日：2024-10-24

申请号：US18290268

申请日：2022-05-11

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Fajun NAN ,  Jingya LI ,  Zheng ZHANG ,  Yanan DUAN ,  Yangming ZHANG ,  Dandan CHEN ,  Chengqiu DAI

IPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/09 ,  A61K31/136 ,  A61K31/145 ,  A61K31/167 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/44 ,  A61K31/505 ,  C07C43/215 ,  C07C43/23 ,  C07C215/76 ,  C07C233/88 ,  C07D213/69 ,  C07D213/74 ,  C07D239/10 ,  C07D307/36 ,  C07D333/06 ,  C07D333/34

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/09 ,  A61K31/136 ,  A61K31/145 ,  A61K31/167 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/44 ,  A61K31/505 ,  C07C43/215 ,  C07C43/23 ,  C07C215/76 ,  C07C233/88 ,  C07D213/69 ,  C07D213/74 ,  C07D239/10 ,  C07D307/36 ,  C07D333/06 ,  C07D333/34

摘要： Provided are a class of alkylphenol compounds and a preparation method therefor. Specifically provided are a new alkyl polyphenol compound as represented by chemical formula I, and a preparation method therefor and the use thereof in the treatment of metabolic syndrome.

公开(公告)号：US12122833B2

公开(公告)日：2024-10-22

申请号：US16541007

申请日：2019-08-14

申请人： HUYABIO International, LLC

发明人： Reid P. Bissonnette ,  Alain Rolland ,  Mireille Gillings

IPC分类号： A61K39/00 ,  A61K31/167 ,  A61K31/18 ,  A61K31/343 ,  A61K31/395 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/4406 ,  A61K31/506 ,  A61K38/15 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC分类号： C07K16/2818 ,  A61K31/167 ,  A61K31/18 ,  A61K31/343 ,  A61K31/395 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/4406 ,  A61K31/506 ,  A61K38/15 ,  A61K39/39541 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/76 ,  A61K31/167 ,  A61K2300/00 ,  A61K31/18 ,  A61K2300/00 ,  A61K31/343 ,  A61K2300/00 ,  A61K31/395 ,  A61K2300/00 ,  A61K31/4045 ,  A61K2300/00 ,  A61K31/4184 ,  A61K2300/00 ,  A61K31/4406 ,  A61K2300/00 ,  A61K31/506 ,  A61K2300/00 ,  A61K38/15 ,  A61K2300/00 ,  A61K39/39541 ,  A61K2300/00

摘要： Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and/or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.

公开(公告)号：US20240335455A1

公开(公告)日：2024-10-10

申请号：US18482935

申请日：2023-10-09

申请人： Albert Einstein College of Medicine

发明人： Evripidis Gavathiotis ,  Richard N. Kitsis ,  Nikolaos Biris ,  Emmanouil Zacharioudakis

IPC分类号： A61K31/551 ,  A61K31/165 ,  A61K31/167 ,  A61K31/277 ,  A61K31/341 ,  A61K31/351 ,  A61K31/402 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/429 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519

CPC分类号： A61K31/551 ,  A61K31/165 ,  A61K31/167 ,  A61K31/277 ,  A61K31/341 ,  A61K31/351 ,  A61K31/402 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/429 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519

摘要： Activators of mitofusins and their uses in treatment of diseases and disorders are disclosed.

公开(公告)号：US20240317696A1

公开(公告)日：2024-09-26

申请号：US18559968

申请日：2022-05-10

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Weizhi GE ,  Shaolong LI ,  Guoli ZHANG ,  Shuhui CHEN

IPC分类号： C07D307/16 ,  A61K31/167 ,  A61K31/341 ,  C07C233/55

CPC分类号： C07D307/16 ,  A61K31/167 ,  A61K31/341 ,  C07C233/55 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2602/14 ,  C07C2602/38 ,  C07C2602/42

摘要： A series of alkyl carboxylic acid compounds and an application thereof, and relates in particular to compounds represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240315994A1

公开(公告)日：2024-09-26

申请号：US18441446

申请日：2024-02-14

申请人： ARPEGGIO BIOSCIENCES, INC.

发明人： Timothy READ ,  Zoe WINIGRAD ,  Ardeshir GOLIAEI ,  Joseph AZOFEIFA ,  John K. DICKSON ,  Jason R. HARRIS ,  Eric MARTIN

IPC分类号： A61K31/167 ,  A61K31/16 ,  A61K31/192 ,  A61K31/277 ,  A61K31/341 ,  A61K31/351 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/433 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/472 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/538 ,  A61K31/5415 ,  C07C233/06 ,  C07D217/18 ,  C07D217/20 ,  C07D239/545 ,  C07D265/36 ,  C07D279/16 ,  C07D471/04 ,  C07D487/04

CPC分类号： A61K31/167 ,  A61K31/16 ,  A61K31/192 ,  A61K31/277 ,  A61K31/341 ,  A61K31/351 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/433 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/472 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/538 ,  A61K31/5415 ,  C07C233/06 ,  C07D217/18 ,  C07D217/20 ,  C07D239/545 ,  C07D265/36 ,  C07D279/16 ,  C07D471/04 ,  C07D487/04

摘要： Provided herein are inhibitors of GPX4, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the GPX4 inhibitory compounds for the modulation of ferroptosis and treatment of disease.

公开(公告)号：US20240307314A1

公开(公告)日：2024-09-19

申请号：US18569780

申请日：2023-05-11

申请人： KYOWA Pharmaceutical Industry Co., Ltd.

发明人： Hiroki SHINGAKI ,  Shota ASAI ,  Fumiyasu TANIGUCHI ,  Junya YAMASHITA

IPC分类号： A61K9/28 ,  A61K9/20 ,  A61K31/167

CPC分类号： A61K9/2866 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2813 ,  A61K9/282 ,  A61K9/286 ,  A61K9/2893 ,  A61K31/167

摘要： By coating an oral solid preparation with a gel film containing a polymer gelable on contact with water, a carbonate, and an acidic substance, obtained oral solid composition is easy to swallow, and elution of active ingredients is suppressed, while the composition can disintegrate in the oral cavity. When an oral solid composition comprising a gel film is hermetically packed or is tightly packed together with a desiccant, discoloration during storage can be suppressed. In a gel film, by setting the concentration of glycerol at 2% by mass or less relative to the total amount of the gel film, mold is prevented from growing. In the case where a coating liquid in which a polymer gelable on contact with water is dispersed is used to form a gel film, the gel film can be formed for a short period of time, even when the coating liquid contains a large amount of the polymer. A gel fil containing titanium oxide at 20% by mass or less can be identifiably marked by ultraviolet laser irradiation.

公开(公告)号：US20240299550A1

公开(公告)日：2024-09-12

申请号：US18625862

申请日：2024-04-03

申请人： UroGen Pharma Ltd.

发明人： Asher Holzer ,  Dorit Daniel ,  Michael Mullerad ,  Jaime De La Zerda ,  Uri Shpolansky ,  Nadav Malchi ,  Yosh Dollberg ,  Dor Tal ,  Yossi Yavin ,  Marina Konorty

IPC分类号： A61K47/34 ,  A61K9/00 ,  A61K9/06 ,  A61K31/07 ,  A61K31/122 ,  A61K31/167 ,  A61K31/192 ,  A61K31/337 ,  A61K31/397 ,  A61K31/407 ,  A61K31/59 ,  A61K31/704 ,  A61K31/7068 ,  A61K38/48 ,  A61K47/10 ,  A61K47/38

CPC分类号： A61K47/34 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/07 ,  A61K31/122 ,  A61K31/167 ,  A61K31/192 ,  A61K31/337 ,  A61K31/397 ,  A61K31/407 ,  A61K31/59 ,  A61K31/704 ,  A61K31/7068 ,  A61K38/4893 ,  A61K47/10 ,  A61K47/38

摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.

公开(公告)号：US20240299321A1

公开(公告)日：2024-09-12

申请号：US18258673

申请日：2021-12-10

申请人： THE TRUSTEES OF INDIANA UNIVERSITY

发明人： Xiongbin LU ,  Xinna ZHANG

IPC分类号： A61K31/167 ,  A61K31/4468 ,  A61K31/517 ,  A61K45/06 ,  A61P35/00 ,  G01N33/50

CPC分类号： A61K31/167 ,  A61K31/4468 ,  A61K31/517 ,  A61K45/06 ,  A61P35/00 ,  G01N33/505 ,  G01N33/5088 ,  G01N2500/10

摘要： This invention is directed to pharmaceutical compositions and methods for increasing immunogenicity in a cancer cell by contacting a cancer cell with epigenetic inhibitors to prompt the cancer cell's production of MHC-I-associated tumor antigens.

公开(公告)号：US12083087B2

公开(公告)日：2024-09-10

申请号：US17867370

申请日：2022-07-18

申请人： Hyloris Pharmaceuticals SA

发明人： Thomas Jacobsen

IPC分类号： A61K31/192 ,  A61J1/10 ,  A61J1/20 ,  A61K9/00 ,  A61K9/08 ,  A61K31/167 ,  A61K47/20 ,  A61K47/26 ,  A61M5/14 ,  A61M5/19

CPC分类号： A61K31/192 ,  A61J1/10 ,  A61J1/2093 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/167 ,  A61K47/20 ,  A61K47/26 ,  A61M5/1407 ,  A61M5/19 ,  A61K31/167 ,  A61K2300/00 ,  A61K31/192 ,  A61K2300/00

摘要： An aqueous ibuprofen and paracetamol composition has a pH 6.3-7.3. The composition can be used as a medicament, especially for the treatment of pain and/or inflammation. The composition can be formulated for intravenous injection.