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公开(公告)号：US20240299550A1
公开(公告)日：2024-09-12
申请号：US18625862
申请日：2024-04-03
申请人： UroGen Pharma Ltd.
发明人： Asher Holzer , Dorit Daniel , Michael Mullerad , Jaime De La Zerda , Uri Shpolansky , Nadav Malchi , Yosh Dollberg , Dor Tal , Yossi Yavin , Marina Konorty
IPC分类号： A61K47/34 , A61K9/00 , A61K9/06 , A61K31/07 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/337 , A61K31/397 , A61K31/407 , A61K31/59 , A61K31/704 , A61K31/7068 , A61K38/48 , A61K47/10 , A61K47/38
CPC分类号： A61K47/34 , A61K9/0034 , A61K9/06 , A61K31/07 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/337 , A61K31/397 , A61K31/407 , A61K31/59 , A61K31/704 , A61K31/7068 , A61K38/4893 , A61K47/10 , A61K47/38
摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.
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公开(公告)号：US20230241221A1
公开(公告)日：2023-08-03
申请号：US18129508
申请日：2023-03-31
申请人： UroGen Pharma Ltd.
发明人： Asher Holzer , Dorit Daniel , Michael Mullerad , Jaime De La Zerda , Uri Shpolansky , Nadav Malchi , Yosh Dollberg , Dor Tal , Yossi Yavin , Marina Konorty
IPC分类号： A61K47/34 , A61K31/407 , A61K31/704 , A61K31/167 , A61K31/7068 , A61K31/397 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/337 , A61K31/192 , A61K38/48 , A61K9/00 , A61K9/06 , A61K47/38 , A61K47/10
CPC分类号： A61K47/34 , A61K9/06 , A61K9/0034 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/337 , A61K31/397 , A61K31/407 , A61K31/704 , A61K31/7068 , A61K38/4893 , A61K47/10 , A61K47/38
摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.
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公开(公告)号：US20230233685A1
公开(公告)日：2023-07-27
申请号：US18129543
申请日：2023-03-31
申请人： UroGen Pharma Ltd.
发明人： Asher Holzer , Dorit Daniel , Michael Mullerad , Jaime De La Zerda , Uri Shpolansky , Nadav Malchi , Yosh Dollberg , Dor Tal , Yossi Yavin , Marina Konorty
IPC分类号： A61K47/34 , A61K31/407 , A61K31/704 , A61K31/167 , A61K31/7068 , A61K31/397 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/337 , A61K31/192 , A61K38/48 , A61K9/00 , A61K9/06 , A61K47/38 , A61K47/10
CPC分类号： A61K47/34 , A61K31/407 , A61K31/704 , A61K31/167 , A61K31/7068 , A61K31/397 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/337 , A61K31/192 , A61K38/4893 , A61K9/0034 , A61K9/06 , A61K47/38 , A61K47/10
摘要： A method of providing sustained-release topical treatment of a condition affecting an internal body cavity is provided. The method comprises administering a pharmaceutical composition comprising a thermoreversible hydrogel and an active pharmaceutical ingredient to an internal body cavity of the urinary tract. After administration, the concentration of the active pharmaceutical ingredient in urothelium of the internal body cavity is increased when compared to the concentration of the active pharmaceutical ingredient in urothelium of the internal body cavity following administration of a control composition comprising the same dose and concentration of active pharmaceutical ingredient in water.
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公开(公告)号：US09950069B2
公开(公告)日：2018-04-24
申请号：US15366256
申请日：2016-12-01
申请人： UroGen Pharma Ltd.
发明人： Asher Holzer , Dorit Daniel , Michael Mullerad , Jaime De La Zerda , Uri Shpolansky , Nadav Malchi , Yosh Dollberg , Dor Tal , Yossi Yavin , Marina Konorty
IPC分类号： A61K47/34 , A61K47/38 , A61K9/06 , A61K31/407 , A61K31/704 , A61K31/167 , A61K31/7068 , A61K47/26 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/337 , A61K9/00 , A61K31/192 , A61K31/79 , A61K38/48
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/0034 , A61K9/006 , A61K9/06 , A61K31/07 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/337 , A61K31/407 , A61K31/59 , A61K31/704 , A61K31/7068 , A61K31/79 , A61K38/2013 , A61K38/4893 , A61K47/10 , A61K47/26 , A61K47/38 , C12Y304/24069
摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.
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公开(公告)号：US20230241220A1
公开(公告)日：2023-08-03
申请号：US18129497
申请日：2023-03-31
申请人： UroGen Pharma Ltd.
发明人： Asher Holzer , Dorit Daniel , Michael Mullerad , Jaime De La Zerda , Uri Shpolansky , Nadav Malchi , Yosh Dollberg , Dor Tal , Yossi Yavin , Marina Konorty
IPC分类号： A61K47/34 , A61K31/407 , A61K31/704 , A61K31/167 , A61K31/7068 , A61K31/397 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/337 , A61K31/192 , A61K38/48 , A61K9/00 , A61K9/06 , A61K47/38 , A61K47/10
CPC分类号： A61K47/34 , A61K31/407 , A61K31/704 , A61K31/167 , A61K31/7068 , A61K31/397 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/337 , A61K31/192 , A61K38/4893 , A61K9/0034 , A61K9/06 , A61K47/38 , A61K47/10
摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.
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公开(公告)号：US10039832B2
公开(公告)日：2018-08-07
申请号：US14720676
申请日：2015-05-22
申请人： UroGen Pharma Ltd.
发明人： Asher Holzer , Dorit Daniel , Michael Mullerad , Jaime De La Zerda , Uri Shpolansky , Nadav Malchi , Yosh Dollberg , Dor Tal , Yossi Yavin , Marina Konorty
IPC分类号： A61K47/34 , A61K9/00 , A61K9/06 , A61K47/10 , A61K47/38 , A61K31/407 , A61K31/704 , A61K38/20 , A61K38/48
摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.
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公开(公告)号：US20170112935A1
公开(公告)日：2017-04-27
申请号：US15366256
申请日：2016-12-01
申请人： UroGen Pharma Ltd.
发明人： Asher Holzer , Dorit Daniel , Michael Mullerad , Jaime De La Zerda , Uri Shpolansky , Nadav Malchi , Yosh Dollberg , Dor Tal , Yossi Yavin , Marina Konorty
IPC分类号： A61K47/34 , A61K9/06 , A61K31/407 , A61K31/704 , A61K31/167 , A61K31/7068 , A61K47/26 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/337 , A61K9/00 , A61K31/192 , A61K31/79 , A61K38/48 , A61K47/38
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/0034 , A61K9/006 , A61K9/06 , A61K31/07 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/337 , A61K31/407 , A61K31/59 , A61K31/704 , A61K31/7068 , A61K31/79 , A61K38/2013 , A61K38/4893 , A61K47/10 , A61K47/26 , A61K47/38 , C12Y304/24069
摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.
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