专利检索 ap:("THE TRUSTEES OF INDIANA UNIVERSITY") AND inv:"Xinna ZHANG" 第 1 页

1.

发明公开
METHODS TO SENSITIZE CANCER CELLS AND STANDARDIZED SCREENING ASSAY FOR IMMUNOTHERAPY 审中-公开

公开(公告)号：US20240299321A1

公开(公告)日：2024-09-12

申请号：US18258673

申请日：2021-12-10

申请人： THE TRUSTEES OF INDIANA UNIVERSITY

发明人： Xiongbin LU , Xinna ZHANG

IPC分类号： A61K31/167 , A61K31/4468 , A61K31/517 , A61K45/06 , A61P35/00 , G01N33/50

CPC分类号： A61K31/167 , A61K31/4468 , A61K31/517 , A61K45/06 , A61P35/00 , G01N33/505 , G01N33/5088 , G01N2500/10

摘要： This invention is directed to pharmaceutical compositions and methods for increasing immunogenicity in a cancer cell by contacting a cancer cell with epigenetic inhibitors to prompt the cancer cell's production of MHC-I-associated tumor antigens.

2.

发明公开
METHODS TO SENSITIZE CANCER CELLS TO IMMUNE ATTACK USING ATRACTYLENOLIDE I 审中-公开

公开(公告)号：US20230404967A1

公开(公告)日：2023-12-21

申请号：US18035694

申请日：2021-11-30

申请人： THE TRUSTEES OF INDIANA UNIVERSITY

发明人： Xiongbin LU , Xinna ZHANG , Kevin VAN DER JEUGHT

IPC分类号： A61K31/365 , A61K45/06 , A61P35/00

CPC分类号： A61K31/365 , A61K45/06 , A61P35/00

摘要： The present disclosure relates to compositions and methods to induce or increase immunogenicity in cancerous cells comprising contacting the cancerous cells with atractylenolide I (ATT-I). In some embodiments, the methods include contacting the cancerous cells with ATT-I in combination with a cancer therapeutic agent.