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公开(公告)号：US20240239854A1
公开(公告)日：2024-07-18
申请号：US18392130
申请日：2023-12-21
发明人： Kirk Czymmek , Dilip M. Shah , Siva L.S. Velivelli , Saurav Misra , Hui Li , Meenakshi Tetorya
CPC分类号： C07K14/4723 , C12N1/16 , C12R2001/72 , C12R2001/78 , C12R2001/84 , C12R2001/85
摘要： Antimicrobial modified defensin or defensin-like peptides, modified C-terminal fragments of a defensin or defensin-like peptides and nucleic acids encoding the same are disclosed. Compositions comprising the defensin variant peptides and methods of their use to control microbial infections of plants and vertebrate subjects as well as contamination of feedstuffs and foodstuffs are also disclosed.
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公开(公告)号：US20240229093A1
公开(公告)日：2024-07-11
申请号：US18562047
申请日：2021-05-20
申请人： Chr. Hansen A/S
发明人： Katja Parschat , Stefan Jennewein
IPC分类号： C12P19/26 , C12N1/16 , C12N1/20 , C12N9/10 , C12R1/07 , C12R1/185 , C12R1/78 , C12R1/84 , C12R1/85
CPC分类号： C12P19/26 , C12N1/16 , C12N1/20 , C12N9/1051 , C12N2500/34 , C12R2001/07 , C12R2001/185 , C12R2001/78 , C12R2001/84 , C12R2001/85 , C12Y204/0109
摘要： Disclosed is a process for the production of a desired oligosaccharide, the process comprises providing a genetically engineered microbial cell which possesses a saccharide importer for the uptake of an intermediate oligosaccharide, and an enzyme being able to convert the intermediated oligosaccharide by transferring a monosaccharide moiety from a donor substrate to the intermediate oligosaccharide; cultivating the genetically engineered microbial cell in the presence of an intermediate oligosaccharide to generate the desired oligosaccharide; and retrieving the desired oligosaccharide.
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公开(公告)号：US09556444B2
公开(公告)日：2017-01-31
申请号：US14477382
申请日：2014-09-04
申请人： Microbiogen Pty Ltd.
摘要： The present invention relates to methods for producing Saccharomyces strains that are capable of growth on xylose as a sole carbon source at a desired growth rate, (such as at least one generation per 48 hours), strains made by such methods, and Saccharomyces strains that grow at a growth rate of at least one generation per 48 hours using xylose as a sole carbon source for growth made by non-recombinant methods.
摘要翻译： 本发明涉及生产能够以所需生长速率（例如每48小时至少一代一代）的木糖作为唯一碳源生长的酵母菌株的方法，通过这些方法制备的菌株和酵母属菌株 以每48小时至少一代的生长速率生长，使用木糖作为通过非重组方法制备的生长的唯一碳源。
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公开(公告)号：US09249419B2
公开(公告)日：2016-02-02
申请号：US13589864
申请日：2012-08-20
摘要： The present invention relates to methods for producing Saccharomyces strains that are capable of growth on xylose as a sole carbon source at a desired growth rate, (such as at least one generation per 48 hours), strains made by such methods, and Saccharomyces strains that grow at a growth rate of at least one generation per 48 hours using xylose as a sole carbon source for growth made by non-recombinant methods.
摘要翻译： 本发明涉及生产能够以所需生长速率（例如每48小时至少一代一代）的木糖作为唯一碳源生长的酵母菌株的方法，通过这些方法制备的菌株和酵母属菌株 以每48小时至少一代的生长速率生长，使用木糖作为通过非重组方法制备的生长的唯一碳源。
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公开(公告)号：US09198439B2
公开(公告)日：2015-12-01
申请号：US14027756
申请日：2013-09-16
摘要： The present invention aims to supply yeasts suitable for breadmaking using a large amount of yeast, as well as compositions that can give a bakery product containing said yeasts. The present invention also relates to a method of preparing a bakery product and a method of selecting yeast strains giving yeasts suitable for breadmaking using a large amount of yeast.
摘要翻译： 本发明旨在提供适用于使用大量酵母的面包制作的酵母，以及可以给予含有所述酵母的烘焙产品的组合物。 本发明还涉及一种制备面包店产品的方法和选择使用大量酵母适用于面包制作的酵母的酵母菌株的方法。
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公开(公告)号：US5945314A
公开(公告)日：1999-08-31
申请号：US829010
申请日：1997-03-31
CPC分类号： C12P19/18
摘要： The present invention relates to a process for synthesizing oligosaccharides. The process involves contacting an acceptor moiety with unpurified sugar-nucleotides and/or unpurified glycosyltransferase to synthesize oligosaccharides.
摘要翻译： 本发明涉及寡糖的合成方法。 该方法包括使受体部分与未纯化的糖 - 核苷酸和/或未纯化的糖基转移酶接触以合成低聚糖。
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7.发明授权Human herpesvirus type 6 protein p100, the corresponding DNA sequences, their preparation and use 失效人类疱疹病毒6型蛋白p100，相应的DNA序列，其制备和应用
公开(公告)号：US5827519A
公开(公告)日：1998-10-27
申请号：US467527
申请日：1995-06-06
IPC分类号： A61K39/395 , A61K38/00 , A61K39/245 , A61K39/42 , A61P31/12 , A61P31/22 , C07K14/02 , C07K14/03 , C07K16/08 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/38 , C12N15/70 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/85 , G01N33/53 , G01N33/571 , G01N33/577 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/16522 , Y10S435/822 , Y10S435/849 , Y10S435/942
摘要： The invention relates to the human herpesvirus type 6 protein p100 and parts thereof having its specific immunological properties. It further relates to antibodies directed to them and to the corresponding DNA sequences. They can be used in pharmaceutical or diagnostic compositions, optionally together with other HHV-6 proteins or the corresponding DNA sequences.
摘要翻译： 本发明涉及人疱疹病毒6型蛋白质p100及其具有其特异性免疫学特性的部分。 它还涉及针对它们的抗体和相应的DNA序列。 它们可以用于药物或诊断组合物，任选地与其他HHV-6蛋白质或相应的DNA序列一起使用。
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公开(公告)号：US5667965A
公开(公告)日：1997-09-16
申请号：US455972
申请日：1995-05-31
IPC分类号： A61K38/00 , A61P31/12 , C07K14/025 , C07K14/16 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/37 , C12P21/02 , C12R1/19 , C12R1/85 , C12P21/06 , C12N7/00 , C12N7/02 , C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C07K2319/61 , C07K2319/80 , C12N2710/20022 , C12N2740/16322 , Y10S530/826
摘要： This invention relates to E2 trans-activation repressors which interfere with normal functioning of the native full-length E2 transcriptional activation protein of the papillomavirus. Native full-length E2 trans-activation protein activates transcription of papillomavirus only through binding to DNA, and it binds to DNA only in the form of a pre-formed homodimer--a pair of identical polypeptide subunits held together by non-covalent interactions. The E2 trans-activation repressors of this invention are proteins, polypeptides or other molecules that dimerize with full-length native E2 polypeptides to form inactive heterodimers, thus interfering with the formation of active homodimers comprising full-length native E2 polypeptides, thereby repressing papillomavirus transcription and replication. The E2 trans-activation repressors of this invention are advantageously used in the treatment of papillomavirus infections and their associated diseases.
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9.发明授权Gene capable of enhancing S-adenosyl-L-methionine accumulation and process for producing S-adenosyl-L-methionine using the same 失效能够增强S-腺苷-L-甲硫氨酸积累的基因和使用该腺苷生成S-腺苷-L-甲硫氨酸的方法
公开(公告)号：US5100786A
公开(公告)日：1992-03-31
申请号：US288890
申请日：1988-12-23
申请人： Naofumi Shiomi , Hideki Fukuda
发明人： Naofumi Shiomi , Hideki Fukuda
IPC分类号： C07K14/395 , C12N15/09 , C12N15/52 , C12N15/54 , C12N15/65 , C12N15/81 , C12P19/40 , C12R1/85
CPC分类号： C12N15/65 , C07K14/395 , C12N15/52 , C12N15/81 , C12P19/40
摘要： A gene which provides resistance to at least one methionine derivative and is capable of enhancing accumulation of S-adenosyl-L-methionine (SAM) in a cell, a hybrid plasmid having the same, a cell transformed with the above hybrid plasmid, and a process for producing SAM using the above cell. According to the present invention, SAM, which has various therapeutic effects, can be producing in a large amount at a low cost.
摘要翻译： 提供对至少一种甲硫氨酸衍生物的抗性并且能够增强细胞中S-腺苷-L-甲硫氨酸（SAM）的积累的基因，具有该蛋白质的杂交质粒，用上述杂交质粒转化的细胞，以及 使用上述细胞生产SAM的方法。 根据本发明，具有各种治疗效果的SAM可以以低成本大量生产。
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10.发明授权Process for preparing an optically active .gamma.-halo-.beta.-hydroxybutyric acid ester 失效制备光学活性γ-卤代-β-羟基丁酸酯的方法
公开(公告)号：US4933282A
公开(公告)日：1990-06-12
申请号：US935199
申请日：1986-11-26
CPC分类号： C12P7/62
摘要： A process for preparing an optically active .gamma.-halo-.beta.-hydroxybutyric acid ester in high yields which comprises subjecting a .gamma.-haloacetoacetic acid ester to the action of a microorganism selected from genus Saccharomyces under an anaerobic condition. When the .gamma.-haloacetoacetic acid ester is subjected to the action of the microorganism in the presence of a ketal, the yield and optical purity can be further increased.
摘要翻译： 一种以高产率制备光学活性的γ-卤代-β-羟基丁酸酯的方法，其包括在厌氧条件下使γ-卤代乙酰乙酸酯起作用于选自酵母属（Saccharomyces）的微生物的作用。 当γ-卤代乙酰乙酸酯在缩酮存在下经受微生物的作用时，可以进一步提高产率和光学纯度。
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