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公开(公告)号：US10934318B1
公开(公告)日：2021-03-02
申请号：US16893890
申请日：2020-06-05
申请人： Barry P. Rosen , Stanislaw F. Wnuk , Masafumi Yoshinaga , Md Abu Hasan Howlader , Sk Md Sazzad Hossain Suzol
发明人： Barry P. Rosen , Stanislaw F. Wnuk , Masafumi Yoshinaga , Md Abu Hasan Howlader , Sk Md Sazzad Hossain Suzol
摘要： The subject invention provides methods and procedures for synthesis and/or semi-synthesis of the novel antibiotic arsinothricin (AST) and derivatives. Arsinothricin (AST), a new broad-spectrum organoarsenical antibiotic, is a non-proteinogenic analog of glutamate that effectively inhibits glutamine synthetase. The subject invention provides chemical synthesis of an intermediate in the pathway of AST synthesis, hydroxyarsinothricin (AST-OH), which can be converted to AST by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. The methods provide a source of the novel antibiotic that will be required for future clinical trials. The subject invention also provides AST derivatives as a new class of antibiotics.
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2.发明申请PROCESSES FOR USING FLUX AGENTS TO FORM POLYCRYSTALLINE GROUP III-GROUP V COMPOUNDS FROM SINGLE SOURCE ORGANOMETALLIC PRECURSORS 审中-公开使用通量代理形成来自单一源组织前体的多晶III族V族化合物的方法公开(公告)号：US20160322224A1
公开(公告)日：2016-11-03
申请号：US15107710
申请日：2014-12-10
发明人： Robert J. WRIGHT , Anatoliy N. SOKOLOV , George L. ATHENS , Peter N. NICKIAS , James C. STEVENS , Liam L. SPENCER , Bruce B. GERHART , Anna M. PICKENS
CPC分类号： H01L21/02546 , C01G28/00 , C07F9/72 , C07F9/74 , C07F19/00 , C09D5/24 , C23C18/1204 , C23C18/1275 , H01L21/02538 , H01L21/02595 , H01L21/02628 , H01L21/3245 , H01L31/184 , Y02E10/544
摘要： The present invention provides methods for using single source organometallic precursors in the fabrication of polycrystalline Group III-Group V compounds, preferably semiconductor compounds. The present invention teaches how to select organometallic ligands in single-source precursors in order to control the stoichiometry of the corresponding Group III-Group V compounds derived from these precursors. The present invention further teaches how to anneal precursors in the presence of one or more flux agents in order to increase the crystalline grain size of polycrystalline Group III-Group V compounds derived from organometallic precursors. This helps to provide Group III-Group V semiconductors with better electronic properties. The flux layer also helps to control the stoichiometry of the Group III-Group V compounds.
摘要翻译： 本发明提供了在制造多晶III-V族化合物，优选半导体化合物中使用单源有机金属前体的方法。 本发明教导了如何选择单源前体中的有机金属配体以控制衍生自这些前体的相应的第III族V族化合物的化学计量。 本发明进一步教导了如何在一种或多种助熔剂的存在下对前体进行退火，以增加衍生自有机金属前驱体的多晶III-V族化合物的晶粒尺寸。 这有助于提供具有更好电子性能的III-V族半导体。 磁通层还有助于控制III族V族化合物的化学计量。
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公开(公告)号：US20130142730A1
公开(公告)日：2013-06-06
申请号：US13676929
申请日：2012-11-14
发明人： Paul GUTSCH , Brian RENZELMANN
IPC分类号： A61K45/06 , A61K31/285 , C07F9/72
CPC分类号： A61K45/06 , A61K31/285 , C07F9/72
摘要： The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
摘要翻译： 本发明提供有机砷。 许多这些化合物对许多人类肿瘤细胞系（包括固体和血液来源）以及来自患有白血病的患者的恶性血细胞具有有效的体外细胞毒活性。
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4.发明授权Preparation of methylene-bridged hetero compounds and novel bis (diorganophosphino) methanes 失效亚甲基桥接的杂化合物和新的双（二有机膦基）甲烷的制备
公开(公告)号：US5698743A
公开(公告)日：1997-12-16
申请号：US756478
申请日：1996-11-26
申请人： Arthur Hohn , Justin Wolf
发明人： Arthur Hohn , Justin Wolf
CPC分类号： C07F9/5009 , C07F9/48 , C07F9/5027 , C07F9/5068
摘要： Preparation of methylene-bridged compounds of the formula I ##STR1## where R.sup.1 to R.sup.4 are identical or different and are each saturated C.sub.1 -C.sub.30 -hydrocarbyl, unsubstituted phenyl, phenyl substituted by substituents inert under the reaction conditions, or hydrogen, E.sup.1 and E.sup.2 are identical or different and are each phosphorus, arsenic or antimony, and X is a chemical bond or oxygen by reacting a tin compound of the general formula II R.sub.3.sup.5 Sn--CH.sub.2 M, II where R.sup.5 is C.sub.1 --C.sub.20 -hydrocarbyl and M is an alkali metal, with a compound of the general formula III ##STR2## where Y is halogen, metallating the thus-obtained tin compound of the general formula IV ##STR3## with an alkali organometallic, and reacting the product with a compound of the general formula V ##STR4## to give a methylene-bridged compound of the formula I. And novel bis(diorganophosphino)methanes.
摘要翻译： 制备式I的亚甲基桥接化合物其中R 1至R 4相同或不同，并且各自为饱和的C 1 -C 30 - 烃基，未被取代的苯基，被在反应条件下为惰性的取代基取代的苯基，或氢，E1和 E2是相同或不同的，分别是磷，砷或锑，X是化学键或氧，通过使通式II R 35 Sn-CH 2 M的II化合物，其中R 5是C 1 -C 20烃基，M是碱 金属与通式III的化合物III，其中Y是卤素，用碱金属有机金属化由此得到的通式IV IV的锡化合物，并将产物与一般化合物 式V化合物，得到式I的亚甲基桥接化合物。和新型双（二有机膦基）甲烷。
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公开(公告)号：US5683656A
公开(公告)日：1997-11-04
申请号：US605746
申请日：1996-02-22
申请人： Klaus Habenstein , Dieter Zopf , Winfried Bursch
发明人： Klaus Habenstein , Dieter Zopf , Winfried Bursch
IPC分类号： G01N21/77 , C07C381/12 , C07C391/00 , C07F9/54 , C07F9/72 , C07F9/74 , C12Q1/26 , C12Q1/28 , G01N21/78 , G01N33/48
CPC分类号： C07F9/723 , C07C381/12 , C07C391/00 , C07F9/5456 , C07F9/743 , C12Q1/26 , C12Q1/28 , Y10T436/144444 , Y10T436/148888
摘要： The present invention relates to reagents and processes for the preparation of diagnostics which use a chromogenic redox detection system and whose chromogenic redox detection system essentially remains unaffected by interference from reducing compounds in the sample material.
摘要翻译： 本发明涉及用于制备诊断的试剂和方法，其使用显色氧化还原检测系统，其显色氧化还原检测系统基本上不受样品材料中还原性化合物的干扰的影响。
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6.发明授权
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公开(公告)号：US3449399A
公开(公告)日：1969-06-10
申请号：US3449399D
申请日：1966-12-27
申请人： MONSANTO CO
发明人： EVANS ROBERT J , TAYLOR KEITH M
IPC分类号： C07F9/72 , C07C121/02 , C07C121/32
CPC分类号： C07C253/30 , C07C255/08
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公开(公告)号：US3304160A
公开(公告)日：1967-02-14
申请号：US29030763
申请日：1963-06-25
申请人： KOPPERS CO INC
发明人： HARRIS JAMES J
IPC分类号： C07B61/00 , C07F5/02 , C07F5/05 , C07F5/06 , C07F7/00 , C07F7/02 , C07F7/08 , C07F7/10 , C07F9/02 , C07F9/06 , C07F9/26 , C07F9/32 , C07F9/6584 , C07F9/6587 , C07F9/68 , C07F9/72 , C07F9/90 , C08G77/60 , C08G79/02 , C09B39/00 , C09B43/00 , C10L1/20
CPC分类号： C07F9/02 , C07C321/00 , C07C323/00 , C07F5/025 , C07F5/05 , C07F5/069 , C07F7/003 , C07F7/006 , C07F7/025 , C07F7/0827 , C07F7/10 , C07F9/062 , C07F9/26 , C07F9/3229 , C07F9/6584 , C07F9/6587 , C07F9/68 , C07F9/72 , C07F9/90 , C08G77/60 , C08G79/02 , C09B39/00 , C09B43/00
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