公开(公告)号：US12193673B2

公开(公告)日：2025-01-14

申请号：US17186363

申请日：2021-02-26

Applicant: Dravid Koura

Inventor： Dravid Koura

IPC: A61B17/10 ,  A61B17/08 ,  C12P13/00 ,  A61B17/29 ,  C07F9/72

Abstract: A clip dispensing system, clip dispenser, and method is described herein for dispensing and applying clips to tissue during minimally invasive surgery. The system may include a grasping surgical instrument having a shaft and a grasping tool, and a clip dispenser assembled to the shaft. The clip dispenser includes an inner tube surrounded by an outer tube and a plurality of clips housed between the inner tube and the outer tube. The clips include a first jaw, an opposing second jaw, and a cavity between the first jaw and the second jaw. The cavity permits the clip to slide along the length of the shaft and over the grasping tool of the grasping surgical instrument to be clamped onto a grasped piece of tissue with the aid of a second grasping instrument.

公开(公告)号：US10934318B1

公开(公告)日：2021-03-02

申请号：US16893890

申请日：2020-06-05

Applicant: Barry P. Rosen ,  Stanislaw F. Wnuk ,  Masafumi Yoshinaga ,  Md Abu Hasan Howlader ,  Sk Md Sazzad Hossain Suzol

Inventor： Barry P. Rosen ,  Stanislaw F. Wnuk ,  Masafumi Yoshinaga ,  Md Abu Hasan Howlader ,  Sk Md Sazzad Hossain Suzol

IPC: C07F9/72 ,  C12P13/00

Abstract: The subject invention provides methods and procedures for synthesis and/or semi-synthesis of the novel antibiotic arsinothricin (AST) and derivatives. Arsinothricin (AST), a new broad-spectrum organoarsenical antibiotic, is a non-proteinogenic analog of glutamate that effectively inhibits glutamine synthetase. The subject invention provides chemical synthesis of an intermediate in the pathway of AST synthesis, hydroxyarsinothricin (AST-OH), which can be converted to AST by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. The methods provide a source of the novel antibiotic that will be required for future clinical trials. The subject invention also provides AST derivatives as a new class of antibiotics.

公开(公告)号：US20160322224A1

公开(公告)日：2016-11-03

申请号：US15107710

申请日：2014-12-10

Applicant: Dow Global Technologies LLC

Inventor： Robert J. WRIGHT ,  Anatoliy N. SOKOLOV ,  George L. ATHENS ,  Peter N. NICKIAS ,  James C. STEVENS ,  Liam L. SPENCER ,  Bruce B. GERHART ,  Anna M. PICKENS

IPC: H01L21/02 ,  H01L31/18 ,  C07F9/74 ,  H01L21/324 ,  C09D5/24 ,  C07F9/72

CPC classification number: H01L21/02546 ,  C01G28/00 ,  C07F9/72 ,  C07F9/74 ,  C07F19/00 ,  C09D5/24 ,  C23C18/1204 ,  C23C18/1275 ,  H01L21/02538 ,  H01L21/02595 ,  H01L21/02628 ,  H01L21/3245 ,  H01L31/184 ,  Y02E10/544

Abstract: The present invention provides methods for using single source organometallic precursors in the fabrication of polycrystalline Group III-Group V compounds, preferably semiconductor compounds. The present invention teaches how to select organometallic ligands in single-source precursors in order to control the stoichiometry of the corresponding Group III-Group V compounds derived from these precursors. The present invention further teaches how to anneal precursors in the presence of one or more flux agents in order to increase the crystalline grain size of polycrystalline Group III-Group V compounds derived from organometallic precursors. This helps to provide Group III-Group V semiconductors with better electronic properties. The flux layer also helps to control the stoichiometry of the Group III-Group V compounds.

Abstract translation: 本发明提供了在制造多晶III-V族化合物，优选半导体化合物中使用单源有机金属前体的方法。 本发明教导了如何选择单源前体中的有机金属配体以控制衍生自这些前体的相应的第III族V族化合物的化学计量。 本发明进一步教导了如何在一种或多种助熔剂的存在下对前体进行退火，以增加衍生自有机金属前驱体的多晶III-V族化合物的晶粒尺寸。 这有助于提供具有更好电子性能的III-V族半导体。 磁通层还有助于控制III族V族化合物的化学计量。

公开(公告)号：US20130142730A1

公开(公告)日：2013-06-06

申请号：US13676929

申请日：2012-11-14

Applicant: ZIOPHARM Oncology, Inc.

Inventor： Paul GUTSCH ,  Brian RENZELMANN

IPC: A61K45/06 ,  A61K31/285 ,  C07F9/72

CPC classification number: A61K45/06 ,  A61K31/285 ,  C07F9/72

Abstract: The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.

Abstract translation: 本发明提供有机砷。 许多这些化合物对许多人类肿瘤细胞系（包括固体和血液来源）以及来自患有白血病的患者的恶性血细胞具有有效的体外细胞毒活性。

公开(公告)号：US5698743A

公开(公告)日：1997-12-16

申请号：US756478

申请日：1996-11-26

Applicant: Arthur Hohn ,  Justin Wolf

Inventor： Arthur Hohn ,  Justin Wolf

IPC: C07F9/46 ,  C07F9/48 ,  C07F9/50 ,  C07F9/70 ,  C07F9/72 ,  C07F9/90 ,  C07F9/92

CPC classification number: C07F9/5009 ,  C07F9/48 ,  C07F9/5027 ,  C07F9/5068

Abstract: Preparation of methylene-bridged compounds of the formula I ##STR1## where R.sup.1 to R.sup.4 are identical or different and are each saturated C.sub.1 -C.sub.30 -hydrocarbyl, unsubstituted phenyl, phenyl substituted by substituents inert under the reaction conditions, or hydrogen, E.sup.1 and E.sup.2 are identical or different and are each phosphorus, arsenic or antimony, and X is a chemical bond or oxygen by reacting a tin compound of the general formula II R.sub.3.sup.5 Sn--CH.sub.2 M, II where R.sup.5 is C.sub.1 --C.sub.20 -hydrocarbyl and M is an alkali metal, with a compound of the general formula III ##STR2## where Y is halogen, metallating the thus-obtained tin compound of the general formula IV ##STR3## with an alkali organometallic, and reacting the product with a compound of the general formula V ##STR4## to give a methylene-bridged compound of the formula I. And novel bis(diorganophosphino)methanes.

Abstract translation: 制备式I的亚甲基桥接化合物其中R 1至R 4相同或不同，并且各自为饱和的C 1 -C 30 - 烃基，未被取代的苯基，被在反应条件下为惰性的取代基取代的苯基，或氢，E1和 E2是相同或不同的，分别是磷，砷或锑，X是化学键或氧，通过使通式II R 35 Sn-CH 2 M的II化合物，其中R 5是C 1 -C 20烃基，M是碱 金属与通式III的化合物III，其中Y是卤素，用碱金属有机金属化由此得到的通式IV IV的锡化合物，并将产物与一般化合物 式V化合物，得到式I的亚甲基桥接化合物。和新型双（二有机膦基）甲烷。

公开(公告)号：US5683656A

公开(公告)日：1997-11-04

申请号：US605746

申请日：1996-02-22

Applicant: Klaus Habenstein ,  Dieter Zopf ,  Winfried Bursch

Inventor： Klaus Habenstein ,  Dieter Zopf ,  Winfried Bursch

IPC: G01N21/77 ,  C07C381/12 ,  C07C391/00 ,  C07F9/54 ,  C07F9/72 ,  C07F9/74 ,  C12Q1/26 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/48

CPC classification number: C07F9/723 ,  C07C381/12 ,  C07C391/00 ,  C07F9/5456 ,  C07F9/743 ,  C12Q1/26 ,  C12Q1/28 ,  Y10T436/144444 ,  Y10T436/148888

Abstract: The present invention relates to reagents and processes for the preparation of diagnostics which use a chromogenic redox detection system and whose chromogenic redox detection system essentially remains unaffected by interference from reducing compounds in the sample material.

Abstract translation: 本发明涉及用于制备诊断的试剂和方法，其使用显色氧化还原检测系统，其显色氧化还原检测系统基本上不受样品材料中还原性化合物的干扰的影响。

公开(公告)号：US3497341A

公开(公告)日：1970-02-24

申请号：US3497341D

申请日：1966-05-19

Applicant: GAF CORP

Inventor： CHIDDIX MAX EUGENE

IPC: C07F9/72 ,  A01N9/00 ,  C07F9/70

CPC classification number: C07F9/723

公开(公告)号：US3449399A

公开(公告)日：1969-06-10

申请号：US3449399D

申请日：1966-12-27

Applicant: MONSANTO CO

Inventor： EVANS ROBERT J ,  TAYLOR KEITH M

IPC: C07F9/72 ,  C07C121/02 ,  C07C121/32

CPC classification number: C07C253/30 ,  C07C255/08

公开(公告)号：US3304160A

公开(公告)日：1967-02-14

申请号：US29030763

申请日：1963-06-25

Applicant: KOPPERS CO INC

Inventor： HARRIS JAMES J

IPC: C07B61/00 ,  C07F5/02 ,  C07F5/05 ,  C07F5/06 ,  C07F7/00 ,  C07F7/02 ,  C07F7/08 ,  C07F7/10 ,  C07F9/02 ,  C07F9/06 ,  C07F9/26 ,  C07F9/32 ,  C07F9/6584 ,  C07F9/6587 ,  C07F9/68 ,  C07F9/72 ,  C07F9/90 ,  C08G77/60 ,  C08G79/02 ,  C09B39/00 ,  C09B43/00 ,  C10L1/20

CPC classification number: C07F9/02 ,  C07C321/00 ,  C07C323/00 ,  C07F5/025 ,  C07F5/05 ,  C07F5/069 ,  C07F7/003 ,  C07F7/006 ,  C07F7/025 ,  C07F7/0827 ,  C07F7/10 ,  C07F9/062 ,  C07F9/26 ,  C07F9/3229 ,  C07F9/6584 ,  C07F9/6587 ,  C07F9/68 ,  C07F9/72 ,  C07F9/90 ,  C08G77/60 ,  C08G79/02 ,  C09B39/00 ,  C09B43/00

公开(公告)号：US2767114A

公开(公告)日：1956-10-16

申请号：US45920354

申请日：1954-09-29

Applicant: BAYER AG

Inventor： EWALD URBSCHAT ,  PAUL-ERNST FROHBERGER

IPC: C07F9/72

CPC classification number: C07F9/72