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公开(公告)号：US12004840B2
公开(公告)日：2024-06-11
申请号：US16313865
申请日：2017-07-07
发明人： Michel M. Maharbiz , Dongjin Seo , Konlin Shen , Jose M. Carmena , Ryan Neely , Elad Alon , Jan Rabaey
IPC分类号： A61B5/00 , A61B5/07 , A61B5/279 , A61B6/42 , A61B8/08 , A61N1/36 , A61N1/372 , A61N1/378 , B06B1/06 , G01N27/327 , A61M39/02 , A61N1/05 , A61N5/10 , A61N7/00
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/279 , A61B5/686 , A61B6/4258 , A61B8/0808 , A61B8/085 , A61B8/0875 , A61B8/48 , A61N1/3605 , A61N1/37205 , A61N1/3787 , B06B1/06 , G01N27/327 , A61B2505/05 , A61B2560/0219 , A61B2562/028 , A61B2562/12 , A61M39/0208 , A61M2205/04 , A61M2205/825 , A61N1/0534 , A61N1/372 , A61N5/1071 , A61N2005/1087 , A61N2007/0021
摘要： Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating one or more implantable devices, as well as methods of electrically stimulating a tissue.
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公开(公告)号：US11786124B2
公开(公告)日：2023-10-17
申请号：US16313858
申请日：2017-07-07
发明人： Michel M. Maharbiz , Jose M. Carmena , Mekhail Anwar , Kristofer S. J. Pister , Stefanie V. Garcia
IPC分类号： A61B5/00 , A61B6/00 , A61N1/378 , A61B8/08 , A61B5/07 , A61N1/36 , A61N1/372 , A61B5/279 , B06B1/06 , G01N27/327 , A61M39/02 , A61N1/05 , A61N5/10 , A61N7/00
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/279 , A61B5/686 , A61B6/4258 , A61B8/085 , A61B8/0808 , A61B8/0875 , A61B8/48 , A61N1/3605 , A61N1/3787 , A61N1/37205 , B06B1/06 , G01N27/327 , A61B2505/05 , A61B2560/0219 , A61B2562/028 , A61B2562/12 , A61M39/0208 , A61M2205/04 , A61M2205/825 , A61N1/0534 , A61N1/372 , A61N5/1071 , A61N2005/1087 , A61N2007/0021
摘要： Described herein is an implantable device comprising a radiation-sensitive element (such as a transistor) configured to modulate a current as a function of radiation exposure to the transistor; and an ultrasonic device comprising an ultrasonic transducer configured to emit an ultrasonic backscatter that encodes the radiation exposure to the transistor. Further described herein is an implantable device comprising a radiation-sensitive element (such as a diode) configured to generate an electrical signal upon encountering radiation; an integrated circuit configured to receive the electrical signal and modulate a current based on the received electrical signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter based on the modulated current encoding information relating to the encountered radiation. Further described are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also describe are computer systems for operating implantable devices, methods of detecting radiation, methods of treating a solid cancer in a subject, and methods of monitoring a subject for recurrence of a solid cancer.
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公开(公告)号：US20230226354A1
公开(公告)日：2023-07-20
申请号：US18095233
申请日：2023-01-10
发明人： Tianhe Zhang
CPC分类号： A61N1/3605 , A61B5/279 , A61B5/7264 , A61B5/0002
摘要： A method of controlling operation of a neurostimulation device comprises receiving, by the neurostimulation device, an indication of a physiological search area of a subject for delivering electrical neurostimulation and a prioritized search list of neurostimulation parameters for neurostimulation therapy delivered to the search area; delivering the neurostimulation therapy to the search area and varying the neurostimulation parameters according to the parameter priority, wherein a highest priority parameter is varied first while lower priority parameters are held constant; determining the optimum value of the highest priority parameter; delivering neurostimulation to the search area using the determined optimum value of the highest priority parameter and varying one or more lower priority parameters according to the parameter priority; and determining optimum lower priority parameters for the neurostimulation.
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公开(公告)号：US11607128B2
公开(公告)日：2023-03-21
申请号：US16313860
申请日：2017-07-07
发明人： Michel M. Maharbiz , Jose M. Carmena , Dongjin Seo , Monica Lin , Meir Marmor , Safa Herfat , Chelsea Shields Bahney
IPC分类号： A61B8/08 , A61B5/00 , A61B6/00 , A61N1/378 , A61B5/07 , A61N1/36 , A61N1/372 , A61B5/279 , B06B1/06 , G01N27/327 , A61M39/02 , A61N1/05 , A61N5/10 , A61N7/00
摘要： Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.
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公开(公告)号：US12097040B2
公开(公告)日：2024-09-24
申请号：US17058671
申请日：2019-01-31
申请人： Coloplast A/S
发明人： Jais Ask Hansen , Lars Erup Larsen , Niels Hvid , Lars Molzen , Finn Speiermann
CPC分类号： A61B5/445 , A61B5/1118 , A61B5/279 , A61F13/00055 , A61F13/02
摘要： Data collection schemes for a wound dressing are disclosed. In an embodiment, a monitor device for a wound dressing system comprises a wound dressing. The wound dressing comprises an electrode assembly, which comprises a plurality of electrodes including a first set of first electrodes and a second set of second electrodes. The monitor device comprises: a processor, memory and a first interface, which comprises a plurality of terminals including a first terminal and a second terminal, and a data collector coupled to the first terminal and the second terminal. The data collector comprises a data collection controller and is configured to: collect data from the plurality of terminals according to a primary data collection scheme; and collect data from the plurality of terminals according to a secondary data collection scheme, wherein the primary data collection scheme is different from the secondary data collection scheme.
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公开(公告)号：US12089962B2
公开(公告)日：2024-09-17
申请号：US17420807
申请日：2019-10-28
发明人： Suho Lee , Younghyun Kim
CPC分类号： A61B5/7225 , A61B5/24 , A61B5/256 , A61B5/279 , H03F1/34 , A61B2560/0468
摘要： Disclosed in various embodiments of the present invention are a method and a device comprising: a first electrode, a second electrode and a third electrode which make contact with the body of a user; an instrumentation amplifier for differentially amplifying signals received from the first electrode and the second electrode; a feedback amplifier for feeding back feedback noise to the body of the user through the third electrode; and a control circuit, wherein the control circuit is configured to analyze a noise level by using a biosignal obtained from the instrumentation amplifier, and control the gain of the feedback amplifier on the basis of the result of the analysis. Various embodiments are possible.
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公开(公告)号：US12059258B2
公开(公告)日：2024-08-13
申请号：US17450601
申请日：2021-10-12
CPC分类号： A61B5/279 , G06F3/015 , G06V10/75 , A61B2560/0228
摘要： The present invention relates to a method for calibrating on-line a direct neural interface implementing a REW-NPLS regression between an output calibration tensor and an input calibration tensor. The REW-NPLS regression comprises a PARAFAC iterative decomposition of the cross covariance tensor between the input calibration tensor and the output calibration tensor, each PARAFAC iteration comprising a sequence of M elementary steps (2401, 2401, . . . 240M) of minimisation of a metric according to the alternating least squares method, each elementary minimisation step relating to a projector and considering the others as constant, said metric comprising a penalisation term that is a function of the norm of this projector, the elements of this projector not being subjected to a penalisation during a PARAFAC iteration f not being penalisable during following PARAFAC iterations. Said calibration method makes it possible to obtain a predictive model of which the non-zero coefficients are sparse blockwise.
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公开(公告)号：US20240148250A1
公开(公告)日：2024-05-09
申请号：US18447228
申请日：2023-08-09
发明人： Michel M. Maharbiz , Jose M. Carmena , Mekhail Anwar , Burak A. Ozilgen , Dongjin Seo , Federica Fava
IPC分类号： A61B5/00 , A61B5/07 , A61B5/279 , A61B6/42 , A61B8/08 , A61N1/36 , A61N1/372 , A61N1/378 , B06B1/06 , G01N27/327
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/279 , A61B5/686 , A61B6/4258 , A61B8/0808 , A61B8/085 , A61B8/0875 , A61B8/48 , A61N1/3605 , A61N1/37205 , A61N1/3787 , B06B1/06 , G01N27/327 , A61M39/0208
摘要： Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.
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公开(公告)号：US11938313B2
公开(公告)日：2024-03-26
申请号：US17452416
申请日：2021-10-27
发明人： John A. Cadwell
CPC分类号： A61N1/0539 , A61B5/063 , A61B5/279 , A61B5/293 , A61N1/0531 , A61N1/37205 , A61B1/313 , A61B2562/046 , A61N1/36064
摘要： A system for deploying an electrode array at a target location through a hole formed in the patient's cranium. The system includes an array of electrodes attached to a substrate and an inserter attached to the substrate and/or the array of electrodes. The inserter, substrate and array of electrodes are configured into a first compressed state and are positioned within the lumen of a cannula. Using the cannula, the system is inserted through the hole, the cannula is then removed, and the inserter is used to transition the substrate and electrode array from the first compressed state to a second uncompressed state, thereby deploying the array of electrodes at the target location.
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公开(公告)号：US20230148863A1
公开(公告)日：2023-05-18
申请号：US17528721
申请日：2021-11-17
申请人： Rekovar, Inc.
发明人： Shiva Sharareh
摘要： The invention refers to a system for delivering a machine-learning based behavioral intervention for the care of withdraw symptoms such as Neonatal Abstinence Syndrome in neonates. The system obtains biosensor or behavioral information about a patient from a wearable device on the patient and makes a determinative recommendation or takes appropriate action based on its evaluation. The biosensor and behavioral information is collected by way of a wearable device over progressive periods of time. When the data is indicative of a need for treatment because the patient is exhibiting symptoms or indicating relapse traits, this information is sent to the system for evaluation. When the data is indicative of a need for treatment, action is taken in the form of a recommendation or when the device is configured to support direct treatment, direct action can be taken to modify alleviate the patient.
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