公开(公告)号：US20170363626A1

公开(公告)日：2017-12-21

申请号：US15627755

申请日：2017-06-20

Applicant: Raymond M. Johnson

Inventor： Raymond M. Johnson

IPC: G01N33/569 ,  G01N33/68 ,  C07K16/28 ,  G01N33/50 ,  C12Q1/68

CPC classification number: G01N33/56972 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C12N5/0087 ,  C12N5/0638 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/505 ,  G01N33/6869 ,  G01N2333/295 ,  G01N2333/5409 ,  G01N2333/5437 ,  G01N2333/70517 ,  G01N2800/26

Abstract: Methods for identifying and isolating CD8 T cells that produce interleukin-13 upon activation are provided. The present methods leverage one or more newly-identified biomarkers to identify such CD8 T cells and, in certain cases, sort the same. Certain methods comprise obtaining a sample from a mammal, quantifying a level of expression of one or more biomarkers therein, and determining if the level of expression is elevated as compared, wherein an elevated expression level is indicative of an active disease state. Antisera and antibodies are also provided. In particular, an anti-C10orf128 antiserum formulated against a particular peptide is provided, such anti-C10orf128 antiserum characterized in that it identifies a subset of CD8 T cells that produce interleukin-13 upon activation.

公开(公告)号：US08633007B2

公开(公告)日：2014-01-21

申请号：US13140496

申请日：2009-12-18

Applicant: Morten Rønn Petersen ,  Anders Miki Bojesen

Inventor： Morten Rønn Petersen ,  Anders Miki Bojesen

IPC: C12N1/20

CPC classification number: G01N33/56911 ,  G01N2333/21 ,  G01N2333/245 ,  G01N2333/295 ,  G01N2333/31 ,  G01N2333/315 ,  G01N2800/364

Abstract: The present invention relates to methods for diagnosing and treatment of a dormant infection of at least one pathogen. The invention further relates to a composition comprising an anti-dormancy factor as well as to said composition for use in a method of diagnosis or treatment and also to a method for manufacturing said composition. The invention further relates to a kit of parts comprising, inter alia, said composition. The invention also relates to a method for activating a dormant infection.

Abstract translation: 本发明涉及用于诊断和治疗至少一种病原体的休眠感染的方法。 本发明还涉及包含抗休眠因子以及用于诊断或治疗方法的所述组合物的组合物，还涉及制备所述组合物的方法。 本发明还涉及包括所述组合物的试剂盒。 本发明还涉及一种激活休眠感染的方法。

公开(公告)号：US08568732B2

公开(公告)日：2013-10-29

申请号：US13255002

申请日：2010-03-08

Applicant: Guido Grandi ,  Oretta Finco ,  Renata Maria Grifantini

Inventor： Guido Grandi ,  Oretta Finco ,  Renata Maria Grifantini

IPC: A61K39/118 ,  A61K39/02 ,  C07K14/195 ,  C07K7/06 ,  C07K7/08

CPC classification number: A61K39/118 ,  A61K39/3955 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K14/295 ,  C07K16/125 ,  G01N33/56927 ,  G01N2333/295 ,  G01N2469/10

Abstract: The invention provides Chlamydia antigens for use in the treatment, prevention and/or diagnosis of Chlamydia infection. In particular, the invention provides antigens CT733, CT153, CT601, CT279, CT443, CT372, CT456, CT381, CT255, CT341, CT716, CT745, CT387, CT812, CT869, CT166, CT175, CT163, CT214, CT721, CT127, CT043, CT823 and/or CT600 from C. trachomatis for the treatment, prevention or diagnosis of Chlamydia infection.

公开(公告)号：US20130017539A1

公开(公告)日：2013-01-17

申请号：US13309363

申请日：2011-12-01

Applicant: Mitra Choudhury Singhal ,  Cori Anne Barfield ,  Kathryn Watts Weaver

Inventor： Mitra Choudhury Singhal ,  Cori Anne Barfield ,  Kathryn Watts Weaver

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6895 ,  G01N2333/295

Abstract: The invention provides methods, reagent, and kits for detecting the presence of Chlamydia trachomatis in a test sample.

Abstract translation: 本发明提供了用于检测测试样品中沙眼衣原体存在的方法，试剂和试剂盒。

公开(公告)号：US20120015386A1

公开(公告)日：2012-01-19

申请号：US13245521

申请日：2011-09-26

Applicant: Morten Ruhwald ,  Pernille Ravn ,  Jesper Eugen-Olsen

Inventor： Morten Ruhwald ,  Pernille Ravn ,  Jesper Eugen-Olsen

IPC: C12Q1/04 ,  G01N33/569

CPC classification number: G01N33/6863 ,  C12Q1/6883 ,  C12Q1/689 ,  C12Q2600/158 ,  G01N33/505 ,  G01N33/56911 ,  G01N33/56927 ,  G01N2333/02 ,  G01N2333/16 ,  G01N2333/295 ,  G01N2333/35 ,  G01N2333/44 ,  Y02A50/451 ,  Y02A50/55

Abstract: The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10. The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other suitable biological samples. The methods of the present invention are useful in therapeutic and diagnostic protocols for human, livestock and veterinary and wild life applications, thus the invention further relates to a method for diagnosing an infection in a mammal.

Abstract translation: 本发明涉及免疫学方法，更具体地说，涉及一种基于IP-10生产测定哺乳动物细胞介导的免疫反应性（CMI）的方法。 本发明还公开了使用全血或其它合适的生物样品测量CMI至抗原的测定和试剂盒。 本发明的方法可用于人类，家畜和兽医和野生生物应用的治疗和诊断方案，因此本发明还涉及用于诊断哺乳动物感染的方法。

公开(公告)号：US20110110857A1

公开(公告)日：2011-05-12

申请号：US12921271

申请日：2009-03-06

Applicant: Roberto Petracca ,  Renata Maria Grifantini ,  Guido Grandi

Inventor： Roberto Petracca ,  Renata Maria Grifantini ,  Guido Grandi

IPC: A61K49/00 ,  C07K14/295 ,  C12N9/48 ,  C07K16/12 ,  C07H21/04 ,  C12N15/70 ,  C12N1/21 ,  A61K39/40 ,  G01N33/53 ,  A61P31/04

CPC classification number: A61K39/118 ,  A61K39/00 ,  A61K2039/55544 ,  A61K2039/55561 ,  C07K14/295 ,  C07K16/125 ,  C07K2317/76 ,  G01N2333/295

Abstract: An immunogenic Chlamydia HtrA protein, which has one or more mutations relative to wild-type Chlamydia HtrA that result in a reduced or eliminated protease activity relative to the protease activity of wild-type Chlamydia HtrA. In some embodiments the serine protease activity is reduced or eliminated.

Abstract translation: 免疫原性衣原体HtrA蛋白，其相对于野生型衣原体HtrA具有一个或多个相对于野生型衣原体HtrA的蛋白酶活性降低或消除的蛋白酶活性的一个或多个突变。 在一些实施方案中，丝氨酸蛋白酶活性被降低或消除。

公开(公告)号：US07534445B2

公开(公告)日：2009-05-19

申请号：US10766711

申请日：2004-01-27

Applicant: W. James Jackson ,  John L. Pace

Inventor： W. James Jackson ,  John L. Pace

IPC: A61K39/118 ,  C07K14/295 ,  C12P21/04 ,  C07H21/04

CPC classification number: G01N33/56927 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/125 ,  G01N2333/295 ,  Y10S514/885 ,  Y10S514/931 ,  Y10S514/937 ,  Y10S530/811 ,  Y10S530/814 ,  Y10S530/82

Abstract: A high molecular weight (“HMW”) protein of chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.

Abstract translation: 公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和与HMW蛋白特异性结合的抗体，以及编码该HMW蛋白的核酸序列。 还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其部分的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

公开(公告)号：US20080220018A1

公开(公告)日：2008-09-11

申请号：US11849931

申请日：2007-09-04

Applicant: John Brownlie ,  Victoria Jane Chalker ,  Kerstin Erles

Inventor： John Brownlie ,  Victoria Jane Chalker ,  Kerstin Erles

IPC: A61K39/155 ,  A61K39/09 ,  A61K39/235 ,  C12Q1/14 ,  A61P11/00 ,  A61K39/245 ,  A61K39/215

CPC classification number: G01N33/6854 ,  A61K39/0241 ,  A61K39/092 ,  A61K39/118 ,  A61K2039/505 ,  A61K2039/552 ,  G01N2333/295 ,  G01N2333/30 ,  G01N2333/315 ,  G01N2800/12

Abstract: A vaccine composition for vaccinating dogs comprising any one or more of (a) an agent capable of raising an immune response against Streptococcus equi sub species zooepidemicus in a dog, (b) an agent capable of raising an immune response against Mycoplasma cynos in a dog, and (c) an agent capable of raising an immune response against a Chlamydophila in a dog.

Abstract translation: 一种用于疫苗接种疫苗的疫苗组合物，其包含以下一种或多种：（a）能够对狗中的链球菌属动物疫苗提供免疫应答的试剂，（b）能够增加狗中支原体的免疫应答的试剂 ，和（c）能够在狗中提高针对衣原体的免疫应答的药剂。

公开(公告)号：US20070292425A1

公开(公告)日：2007-12-20

申请号：US11781203

申请日：2007-07-20

Applicant: W. JACKSON

Inventor： W. JACKSON

IPC: A61K39/02 ,  A61K31/7105 ,  A61K39/395 ,  C07K14/295 ,  C12N1/21 ,  C12N15/85 ,  G01N33/68 ,  C12Q1/68 ,  C12N15/31 ,  C07K16/12 ,  A61P31/04 ,  A61K31/711

CPC classification number: A61K39/118 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K39/00 ,  A61K49/0008 ,  A61K2039/505 ,  A61K2039/543 ,  A61K2039/55544 ,  C07H21/04 ,  C07K14/295 ,  C07K16/125 ,  C12Q1/6893 ,  G01N33/56927 ,  G01N2333/295

Abstract: The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived therefrom, (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that specifically bind the PMP polypeptides and PMP-derived polypeptides and T-cells specific for PMP polypeptides and PMP-derived polypeptides. Also disclosed are prophylactic and therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising PMP polypeptides or PMP-derived polypeptides or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Chlamydia cells, Chlamydia elementary bodies, and/or cells expressing Chlamydial proteins, e.g., cell infected with Chlamydia.

Abstract translation: 本发明公开了衣原体PMPE和PMPI多肽，由其衍生的多肽（PMP衍生多肽），编码所述多肽的核苷酸序列，特异性结合PMP多肽和PMP衍生多肽的抗体以及对PMP多肽和PMP- 衍生的多肽。 还公开了预防和治疗组合物，包括免疫原性组合物，例如包含PMP多肽或PMP衍生的多肽或其抗体的疫苗。 本发明还公开了在动物中诱导对衣原体细胞，衣原体基因体和/或表达衣原体蛋白（例如感染衣原体的细胞）的细胞的免疫应答的方法。

公开(公告)号：US20070286768A1

公开(公告)日：2007-12-13

申请号：US11803549

申请日：2007-05-15

Applicant: Paolo Giordano

Inventor： Paolo Giordano

IPC: B01J19/00

CPC classification number: B01L3/50825 ,  B01L3/502 ,  B01L3/5029 ,  B01L3/5082 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2400/0683 ,  G01N33/5304 ,  G01N2333/295 ,  G01N2333/315

Abstract: A system and a method of the interaction and preservation of two or more reagents used in a chemical reaction is described, in which the reagents are put in contact one with another only when a buffer (A) carrying a sample to be treated with said reagents breaks a partition barrier (4, 14) placed between two containers belonging to a device comprising a first upper container (2, 12) and a second lower container (3, 13) of a test tube (1), the bottom wall of the first container (2, 12) forming said partition barrier (4, 14) able to be perforated by the buffer (A) carrying the sample to be treated.

Abstract translation: 描述了在化学反应中使用的两种或更多种试剂的相互作用和保存的系统和方法，其中只有当携带用所述试剂处理的样品的缓冲液（A）时，试剂与另一种反应物接触， 打破位于属于包括试管（1）的第一上容器（2,12）和第二下容器（3,13）的装置的两个容器之间的分隔壁（4,14），所述第一上容器 形成能够承载待处理样品的缓冲器（A）穿孔的所述分隔壁（4,14）的第一容器（2,12）。