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1.发明申请公开(公告)号：US20150344913A1
公开(公告)日：2015-12-03
申请号：US14717019
申请日：2015-05-20
Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA , KYOTO UNIVERSITY
Inventor： Chikara OHTO , Masayoshi MURAMATSU , Masakazu ITO , Jun OGAWA , Shigenobu KISHINO
IPC: C12P5/02
CPC classification number: C12P5/02 , C12P7/04 , C12Y102/0105
Abstract: This invention provides a recombinant microorganism into which an acyl-CoA reductase exerting excellent activity in a reduction reaction involving the use of acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding a protein (a) or (b) below introduced into a host microorganism: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence having 70% or higher identity to the amino acid sequence of SEQ ID NO: 2 and having activity for synthesizing an aldehyde compound from acyl-CoA.
Abstract translation: 本发明提供了一种重组微生物，其中引入了在涉及使用酰基辅酶A作为底物的还原反应中具有优异活性的酰基辅酶A还原酶。 这样的重组微生物包含编码下文中引入到宿主微生物中的蛋白质（a）或（b））的核酸：（a）包含SEQ ID NO：2的氨基酸序列的蛋白质; 或（b）包含与SEQ ID NO：2的氨基酸序列具有70％或更高同一性的氨基酸序列并具有从酰基辅酶A合成醛化合物的活性的蛋白质。
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2.发明申请RECOMBINANT MICROORGANISM AND METHOD FOR PRODUCING A SUBSTANCE USING THE SAME 审中-公开重组微生物和使用该物质生产物质的方法公开(公告)号：US20150344851A1
公开(公告)日：2015-12-03
申请号：US14716973
申请日：2015-05-20
Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA , KYOTO UNIVERSITY
Inventor： Chikara OHTO , Masayoshi MURAMATSU , Masakazu ITO , Jun OGAWA , Shigenobu KISHINO
CPC classification number: C12N9/0008 , C12P5/00 , C12P7/04 , C12P7/24 , C12Y102/0105
Abstract: This invention provides a recombinant microorganism into which an acyl-CoA reductase exhibiting excellent activity in a reduction reaction using acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding an acyl-CoA reductase comprising any of characteristic Common sequences 1 to 3 introduced into a host microorganism.
Abstract translation: 本发明提供一种重组微生物，其中引入了使用酰基辅酶A作为底物的还原反应中表现出优异活性的酰基辅酶A还原酶。 这种重组微生物包含编码引入宿主微生物中的任何特征性通用序列1-3的酰基辅酶A还原酶的核酸。
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公开(公告)号：US20130224818A1
公开(公告)日：2013-08-29
申请号：US13774647
申请日：2013-02-22
Applicant: Shell Oil Company
Inventor： Thomas Paul HOWARD , Sabine MIDDELHAUFE , Dagmara KOLAK , Stephen J. AVES , John LOVE , David PARKER , George Robert LEE
IPC: C12P5/02
CPC classification number: C12P5/02 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N9/93 , C12P5/026 , C12P7/24 , C12Y102/0105 , C12Y203/01 , C12Y301/02014 , C12Y401/99005 , C12Y602/01019
Abstract: A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-ACP, or a fatty acyl-CoA or a mixture of any of these, to obtain a fatty aldehyde; and contacting the fatty aldehyde with at least one aldehyde decarbonylase enzyme.
Abstract translation: 一种制备烃的方法，包括使脂肪酸底物与至少一种脂肪酸还原酶和至少一种脂肪醛合成酶和至少一种脂肪酰基转移酶接触，其中所述脂肪酸底物是脂肪酸，脂肪酰基-ACP， 或脂肪酰基辅酶A或它们的混合物，得到脂肪醛; 并使脂肪醛与至少一种醛脱羰酶接触。
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公开(公告)号：US20170175152A1
公开(公告)日：2017-06-22
申请号：US15363043
申请日：2016-11-29
Applicant: ExxonMobil Research and Engineering Company
Inventor： Kelsey M. McNEELY , Virginia M. REINER
CPC classification number: C12P7/6436 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/93 , C12P7/649 , C12Y102/0105 , C12Y108/01009 , C12Y203/01086 , C12Y207/00 , C12Y301/02002 , C12Y602/01 , C12Y602/01001 , Y02E50/13
Abstract: Methods are provided for biological conversion of anhydrosugars, such as anhydrosugars found in a pyrolysis oil, to fatty acid alkyl esters. The methods can include use of a genetically modified Escherichia coli (E. coli) bacteria that can convert levoglucosan and/or other anhydrosugars into fatty acid alkyl esters without requiring formation and conversion of an intermediate compound external to the bacteria. Optionally, the methods can be used in combination with methods for production and/or separation of increased amounts of levoglucosan from pyrolysis of biomass.
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5.发明申请MICROORGANISMS AND METHODS FOR PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS AND RELATED COMPOUNDS 审中-公开用于生产特定长度脂肪醇及相关化合物的微生物和方法公开(公告)号：US20150275242A1
公开(公告)日：2015-10-01
申请号：US14435723
申请日：2013-10-14
Applicant: GENOMATICA, INC.
Inventor： Robin E. Osterhout , Anthony P. Burgard
IPC: C12P7/64 , C12N9/04 , C12N9/88 , C07C31/20 , C12N9/00 , C12N9/12 , C12N9/16 , C12N9/10 , C12N9/02
CPC classification number: C12P7/64 , C07C31/207 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1025 , C12N9/1029 , C12N9/1217 , C12N9/1294 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/04 , C12P7/24 , C12P7/6409 , C12Y101/01035 , C12Y101/01037 , C12Y101/05004 , C12Y101/05006 , C12Y101/99033 , C12Y102/01 , C12Y102/01002 , C12Y102/01003 , C12Y102/0101 , C12Y102/01015 , C12Y102/01018 , C12Y102/01027 , C12Y102/01042 , C12Y102/0105 , C12Y102/01076 , C12Y102/05001 , C12Y103/01044 , C12Y103/99012 , C12Y203/01008 , C12Y203/01016 , C12Y203/01054 , C12Y203/01174 , C12Y203/03008 , C12Y207/02001 , C12Y207/02007 , C12Y207/09002 , C12Y208/03003 , C12Y301/03001 , C12Y301/03002 , C12Y301/0302 , C12Y301/0306 , C12Y401/01 , C12Y401/01001 , C12Y401/01003 , C12Y401/01007 , C12Y401/01009 , C12Y401/01031 , C12Y401/01032 , C12Y401/01049 , C12Y401/01074 , C12Y401/01082 , C12Y401/02005 , C12Y401/03006 , C12Y401/03034 , C12Y402/01017 , C12Y602/01001 , C12Y602/01013 , C12Y602/01018 , C12Y604/01001
Abstract: The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.
Abstract translation: 本发明提供了包含脂肪醇，脂肪醛或脂肪酸途径的非天然存在的微生物，其中微生物有选择地产生具有特定长度的脂肪醇，脂肪醛或脂肪酸。 还提供了具有脂肪醇，脂肪醛或脂肪酸途径的非天然存在的微生物，其中所述微生物进一步包括乙酰辅酶A途径。 在一些方面，本发明的微生物有选择性的基因破坏或酶减弱，其增加脂肪醇，脂肪醛或脂肪酸的产生。 本发明另外提供使用上述微生物生产脂肪醇，脂肪醛或脂肪酸的方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20140357727A1
公开(公告)日：2014-12-04
申请号：US14366553
申请日：2012-12-13
Applicant: Codexis, Inc.
Inventor： Louis A. Clark , Kristian Karlshoej , Patricia Choudhary
CPC classification number: C12P7/04 , A61K8/342 , A61K2800/10 , A61Q5/00 , A61Q19/00 , C07C31/125 , C12N9/0008 , C12Y102/01 , C12Y102/0105 , C12Y102/0108 , Y02P20/52
Abstract: The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides fatty acyl-CoA reductase (FAR) variant enzymes, polynucleotides encoding the FAR variant enzymes, and vectors and host cells comprising polynucleotides encoding the FAR variant enzymes.
Abstract translation: 本公开内容提供了用于从重组宿主细胞产生脂肪醇组合物的方法。 本公开进一步提供脂肪酰辅酶A还原酶（FAR）变体酶，编码FAR变体酶的多核苷酸，以及包含编码FAR变体酶的多核苷酸的载体和宿主细胞。
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7.发明申请公开(公告)号：US20140242655A1
公开(公告)日：2014-08-28
申请号：US14130117
申请日：2012-06-29
Applicant: Paul S. Pearlman , Changlin Chen , Adriana Leonora Botes , Alex Van Eck Conradie , Benjamin D. Herzog
Inventor： Paul S. Pearlman , Changlin Chen , Adriana Leonora Botes , Alex Van Eck Conradie , Benjamin D. Herzog
IPC: C12P7/44
CPC classification number: C12P7/44 , B29B9/16 , C08G69/14 , C08G69/16 , C08G69/26 , C08G69/28 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1025 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12P7/40 , C12P7/42 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02 , C12P13/04 , C12P17/10 , C12Y102/0105 , C12Y102/99006 , C12Y208/03012 , C12Y208/03013 , C12Y301/02018 , C12Y301/02019 , C12Y301/0202 , C12Y602/01014 , C12Y602/01023
Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
Abstract translation: 本发明的实施方案涉及在分离的酶存在下或在表达这些酶的重组宿主细胞的存在下生物合成二官能或三官能C7烷烃的方法。 二 - 或三官能C7烷烃可用作生产尼龙-7，尼龙-7，x，尼龙-X，7和聚酯的中间体。
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公开(公告)号：US09850504B2
公开(公告)日：2017-12-26
申请号：US14902565
申请日：2014-07-02
Applicant: Scientist of Fortune S.A. , Global Bioenergies
Inventor： Philippe Marliere , Maria Anissimova , Mathieu Allard
IPC: C12N9/88 , C12P7/16 , C12N1/00 , C12P5/02 , C12P7/26 , C12N9/04 , C12N9/02 , C12N15/52 , C12P7/04 , C12N15/70 , C12P19/32
CPC classification number: C12P7/16 , C12N1/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/88 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/04 , C12P7/26 , C12P19/32 , C12Y101/01001 , C12Y101/0103 , C12Y101/01034 , C12Y101/01184 , C12Y102/0105 , C12Y103/08001 , C12Y402/01017 , C12Y402/01018 , C12Y402/01055 , C12Y402/01059 , C12Y402/01074 , C12Y402/01116 , C12Y402/01127 , Y02E50/10
Abstract: Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.
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公开(公告)号：US09714437B2
公开(公告)日：2017-07-25
申请号：US15149859
申请日：2016-05-09
Applicant: Codexis, Inc.
Inventor： Kaman Chan , Fernando Valle , Yoram Barak , Louis Clark , Kristian Karlshoej , Jonathan Vroom , Jovana Nazor , Claus M Krebber , Kenneth Mitchell
IPC: C12N15/00 , C12P7/04 , C12N9/10 , C12N9/16 , C12N9/00 , A61K8/34 , A61Q19/00 , C07C31/125 , C11D3/20 , C12P5/02 , C12P7/64 , C12N9/02 , C12N15/70
CPC classification number: C12P7/04 , A61K8/342 , A61K2800/10 , A61Q19/00 , C07C31/125 , C11D3/2031 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/70 , C12P5/02 , C12P7/6436 , C12Y102/0105 , C12Y203/01086 , C12Y301/02 , C12Y301/02014 , C12Y602/01003 , Y02E50/17
Abstract: The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase (“FAR”); a gene encoding a heterologous thioesterase (“TE”) gene and a gene encoding an acyl-CoA synthetase (“ACS”).
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公开(公告)号：US09650653B2
公开(公告)日：2017-05-16
申请号：US14130117
申请日：2012-06-29
Applicant: Paul S. Pearlman , Changlin Chen , Adriana L. Botes , Alex Van Eck Conradie , Benjamin D. Herzog
Inventor： Paul S. Pearlman , Changlin Chen , Adriana L. Botes , Alex Van Eck Conradie , Benjamin D. Herzog
IPC: C12P7/44 , C12P13/04 , C12P17/10 , C12P7/42 , C12P13/00 , C12P13/02 , C08G69/16 , C08G69/14 , C08G69/26 , C08G69/28 , B29B9/16 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/16 , C12N9/88 , C12N9/00 , C12P7/40 , C12P7/62
CPC classification number: C12P7/44 , B29B9/16 , C08G69/14 , C08G69/16 , C08G69/26 , C08G69/28 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1025 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12P7/40 , C12P7/42 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02 , C12P13/04 , C12P17/10 , C12Y102/0105 , C12Y102/99006 , C12Y208/03012 , C12Y208/03013 , C12Y301/02018 , C12Y301/02019 , C12Y301/0202 , C12Y602/01014 , C12Y602/01023
Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
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