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1.发明公开公开(公告)号：US20240252639A1
公开(公告)日：2024-08-01
申请号：US18562035
申请日：2022-04-14
发明人： Michael VERNERIS , Jessica LAKE
IPC分类号： A61K39/00 , A61K35/17 , A61P35/00 , C07K14/715 , C07K16/28 , C12N5/0783 , C12N15/86
CPC分类号： A61K39/4631 , A61K35/17 , A61K39/4611 , A61K39/464421 , A61K39/464429 , A61P35/00 , C07K14/7158 , C07K16/2827 , C12N5/0636 , C12N15/86 , A61K2239/13 , A61K2239/46 , C07K2317/622 , C12N2501/2308 , C12N2510/00
摘要： Embodiments relate to novel compositions and methods for treating solid tumors. Other embodiments relate to generating T cells able to home to and treat solid tumors. In accordance with these embodiments, T-cells expressing at least one C-X-C Motif Chemokine Receptor (CXCR) and chimeric antigen receptors (CARs) able to bind to B7H3 are disclosed. In certain embodiments, the present disclosure provides for polynucleotides and vectors encoding a CAR and a CXCR together or in separate constructs, where the CAR binds to B7H3 in solid tumor cells, other tumors, or malignancies. In other embodiments, methods of making T cells expressing a CAR that binds to B7H3 and expressing one or more CXCR are provided. In some embodiments, methods of preventing, treating, or ameliorating tumors or malignancies in a subject are disclosed including administering a composition of T cells expressing at least one CXCR and CARs that bind to B7H3.
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公开(公告)号：US11642373B2
公开(公告)日：2023-05-09
申请号：US16345366
申请日：2017-10-25
申请人： LIFT BIOSCIENCES LTD
发明人： Alex Blyth , Nico Bruyniks
IPC分类号： A61K35/15 , A61P35/00 , A61K35/28 , C12N5/0787 , C12N5/0789 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K38/19 , A61K38/20 , A61K38/27 , G01N33/574
CPC分类号： A61K35/15 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K35/28 , A61K38/193 , A61K38/20 , A61K38/27 , A61P35/00 , C12N5/0642 , C12N5/0647 , G01N33/57438 , C12N2500/32 , C12N2500/38 , C12N2501/02 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2304 , C12N2501/2306 , C12N2501/2308 , C12N2501/2318 , C12N2501/25 , C12N2501/26 , C12N2501/305 , C12N2501/825 , C12N2506/11 , C12N2506/45
摘要： The present invention relates to an in vitro culture of haematopoietic cells, wherein said haematopoietic cells differentiate to form granulocytes characterised by the ability to kill cancer cells. The invention also relates to said granulocytes, methods for identifying said haematopoietic cells and granulocytes, compositions and kits comprising the same, as well as uses of the same for treating cancer.
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公开(公告)号：US20170233697A1
公开(公告)日：2017-08-17
申请号：US15248629
申请日：2016-08-26
申请人： Rafael Gonzalez
发明人： Rafael Gonzalez
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N5/0665 , C12N2501/10 , C12N2501/11 , C12N2501/115 , C12N2501/125 , C12N2501/13 , C12N2501/148 , C12N2501/15 , C12N2501/165 , C12N2501/17 , C12N2501/21 , C12N2501/22 , C12N2501/23 , C12N2501/2303 , C12N2501/2304 , C12N2501/2306 , C12N2501/2307 , C12N2501/2308 , C12N2501/2318 , C12N2501/25 , C12N2502/025 , C12N2533/54 , C12N2533/90
摘要： The invention provides methods for using Umbilical Cord Lining Stem Cells (ULSCs) to produce therapeutic factors including growth factors, cytokines, chemokines and extracellular matrix components. ULSCs are mesenchymal stem cells isolated from umbilical cord lining. They can be efficiently propagated and expanded in vitro. Under specific conditions ULSCs produce useful therapeutic factors that can be used to treat injuries and degenerative conditions.
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公开(公告)号：US12070473B2
公开(公告)日：2024-08-27
申请号：US16759293
申请日：2018-04-24
申请人： LIFT BIOSCIENCES LTD
发明人： Alex Blyth , Nico Bruyniks
IPC分类号： A61K35/15 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/27 , A61P35/00 , C12N5/0787 , C12N5/0789 , G01N33/574 , A61K48/00
CPC分类号： A61K35/15 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K35/28 , A61K38/193 , A61K38/20 , A61K38/27 , A61P35/00 , C12N5/0642 , C12N5/0647 , G01N33/57438 , C12N2500/32 , C12N2500/38 , C12N2501/02 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2304 , C12N2501/2306 , C12N2501/2308 , C12N2501/2318 , C12N2501/25 , C12N2501/26 , C12N2501/305 , C12N2501/825 , C12N2506/11 , C12N2506/45
摘要： The present invention relates to an in vitro culture of haematopoietic cells, wherein the haematopoietic cells differentiate to form granulocytes characterised by the ability to kill cancer cells. The invention also relates to the granulocytes, methods for identifying the haematopoietic cells and granulocytes, compositions and kits comprising the same, as well as uses of the same for treating cancer.
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公开(公告)号：US20240197776A1
公开(公告)日：2024-06-20
申请号：US18512933
申请日：2023-11-17
申请人： LIFT BIOSCIENCES LTD
发明人： Alex Blyth , Nico Bruyniks
IPC分类号： A61K35/15 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/27 , A61P35/00 , C12N5/0787 , C12N5/0789 , G01N33/574
CPC分类号： A61K35/15 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K35/28 , A61K38/193 , A61K38/20 , A61K38/27 , A61P35/00 , C12N5/0642 , C12N5/0647 , G01N33/57438 , C12N2500/32 , C12N2500/38 , C12N2501/02 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2304 , C12N2501/2306 , C12N2501/2308 , C12N2501/2318 , C12N2501/25 , C12N2501/26 , C12N2501/305 , C12N2501/825 , C12N2506/11 , C12N2506/45
摘要： The present invention relates to an in vitro culture of haematopoietic cells, wherein said haematopoietic cells differentiate to form granulocytes characterised by the ability to kill cancer cells. The invention also relates to said granulocytes, methods for identifying said haematopoietic cells and granulocytes, compositions and kits comprising the same, as well as uses of the same for treating cancer.
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公开(公告)号：US20230346834A1
公开(公告)日：2023-11-02
申请号：US18189826
申请日：2023-03-24
申请人： LIfT BioSciences Ltd
发明人： Alex Blyth , Nico Bruyniks
IPC分类号： A61K35/15 , A61P35/00 , A61K35/28 , C12N5/0787 , C12N5/0789 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K38/19 , A61K38/20 , A61K38/27 , G01N33/574
CPC分类号： A61K35/15 , A61P35/00 , A61K35/28 , C12N5/0642 , C12N5/0647 , A61K31/198 , A61K31/202 , A61K31/375 , A61K31/59 , A61K38/193 , A61K38/20 , A61K38/27 , G01N33/57438 , C12N2500/32 , C12N2500/38 , C12N2501/02 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2304 , C12N2501/2306 , C12N2501/2308 , C12N2501/2318 , C12N2501/25 , C12N2501/26 , C12N2501/305 , C12N2501/825 , C12N2506/11 , C12N2506/45
摘要： The present invention relates to an in vitro culture of haematopoietic cells, wherein said haematopoietic cells differentiate to form granulocytes characterised by the ability to kill cancer cells. The invention also relates to said granulocytes, methods for identifying said haematopoietic cells and granulocytes, compositions and kits comprising the same, as well as uses of the same for treating cancer.
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公开(公告)号：US12077777B2
公开(公告)日：2024-09-03
申请号：US17346980
申请日：2021-06-14
发明人： Jau-Nan Lee , Yuta Lee , Tony Tung-Yin Lee
CPC分类号： C12N5/0605 , A61K35/50 , A61K35/54 , C12N5/0603 , A61K2035/122 , C12N2501/115 , C12N2501/2306 , C12N2501/2308 , C12N2506/025
摘要： Disclosed herein are precursory regulatory cytotrophoblast cells produced in vitro and compositions thereof. Disclosed herein are isolated populations of precursory regulatory cytotrophoblast cells, where the cells are produced in vitro. Disclosed herein are genetically engineered cells. Also disclosed herein are methods of treating a disorder or condition by utilizing the cells disclosed herein.
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8.发明授权公开(公告)号：US11834673B2
公开(公告)日：2023-12-05
申请号：US17398328
申请日：2021-08-10
CPC分类号： C12N5/0631 , A61K35/55 , C12N2501/2308 , C12N2513/00
摘要： The invention relates to methods for generating multipotent mammary stern cells from isolated and cultured human breast luminal cells. The method comprises the steps: 1. isolating and growing normal differentiated cells in vitro; 2. treating the differentiated cells with either a conditioned medium from active fibroblasts or cytokine. The invention also relates to multipotent mammary stem cells, cultures of the multipotent stem cells, differentiated cells, tissues, organs derived from the culture multipotent stem cells isolated by the methods disclosed and therapeutic and other uses for those cells thereof.
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9.发明申请公开(公告)号：US20180305662A1
公开(公告)日：2018-10-25
申请号：US16029858
申请日：2018-07-09
CPC分类号： C12N5/0602 , A61K35/12 , C12N2501/2308
摘要： The invention relates to methods for generating multipotent mammary stem cells from isolated and cultured human breast luminal cells. The method comprises the steps: 1. isolating and growing normal differentiated cells in vitro; 2. treating the differentiated cells with either a conditioned medium from active fibroblasts or cytokine. The invention also relates to multipotent mammary stem cells, cultures of the multipotent stem cells, differentiated cells, tissues, organs derived from the culture multipotent stem cells isolated by the methods disclosed and therapeutic and other uses for those cells thereof.
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公开(公告)号：US20240352406A1
公开(公告)日：2024-10-24
申请号：US18639518
申请日：2024-04-18
发明人： Richard C. Jin
CPC分类号： C12N5/0018 , A61K9/06 , A61K9/1658 , A61K47/36 , C12N5/0625 , C12N5/0654 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/12 , C12N2501/13 , C12N2501/135 , C12N2501/148 , C12N2501/15 , C12N2501/155 , C12N2501/165 , C12N2501/19 , C12N2501/22 , C12N2501/2301 , C12N2501/2306 , C12N2501/2308 , C12N2501/25 , C12N2502/1142 , C12N2502/1323
摘要： The present invention is drawn, in part, to biocompatible compositions comprising a biocompatible polymer matrix and conditioned cell medium comprising i) a cell culture medium and ii) one or more agents synthesized by and secreted from one or more cells cultured in the cell culture medium, as well as therapeutic uses thereof, particularly in modulating bone and/or gum tissue growth.
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