Temperature Sensitive Polymers
    7.
    发明申请
    Temperature Sensitive Polymers 有权
    温度敏感聚合物

    公开(公告)号:US20080050435A1

    公开(公告)日:2008-02-28

    申请号:US10593529

    申请日:2005-03-17

    Abstract: The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly ploy (hydroxyalkyl (meth) acrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention comprise monomers, which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.

    Abstract translation: 本发明涉及包含聚合物的组合物,其溶解度特性可以通过孵育而改变,特别是((羟基烷基(甲基)丙烯酰胺单/二乳酸羟烷基酯)互聚物。 本发明的另一方面是这种温度敏感聚合物作为生物活性化合物的释放体系的应用。 本发明的聚合物包含具有可修饰官能团的单体。 单体的官能度可以例如通过可水解基团的存在来改性。 通过孵育实现修饰,导致聚合物的水溶性特征的变化。 用于本发明的聚合物含有可水解的化学基团。 因此,聚合物的溶液特性,特别是其较低临界溶解温度(LCST)的温度变化。

    Temperature sensitive polymers
    8.
    发明申请
    Temperature sensitive polymers 有权
    温度敏感聚合物

    公开(公告)号:US20040247670A1

    公开(公告)日:2004-12-09

    申请号:US10804302

    申请日:2004-03-18

    Abstract: The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly poly (N-(2-hydroxypropyl)methacrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention, comprise monomers which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.

    Abstract translation: 本发明涉及包含聚合物的组合物,其溶解度特性可以通过孵育而改变,特别是聚(N-(2-(2-羟丙基)甲基丙烯酰胺单/二乳酸酯)互聚物。 本发明的另一方面是这种温度敏感聚合物作为生物活性化合物的释放体系的应用。 本发明的聚合物包括具有可修饰官能团的单体。 单体的官能度可以例如通过可水解基团的存在来改性。 通过孵育实现修饰,导致聚合物的水溶性特征的变化。 用于本发明的聚合物含有可水解的化学基团。 因此,聚合物的溶液特性,特别是其较低临界溶解温度(LCST)的温度变化。

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