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    ANTI-IDIOTYPE MONOCLONAL ANTIBODIES AS MIMOTOPES OF THE HIV GP120 ANTIGEN
    1.
    发明申请
    ANTI-IDIOTYPE MONOCLONAL ANTIBODIES AS MIMOTOPES OF THE HIV GP120 ANTIGEN 有权
    作为HIV GP120抗原的抗体的单抗单克隆抗体

    公开(公告)号：US20100008905A1

    公开(公告)日：2010-01-14

    申请号：US12524816

    申请日：2008-01-29

    申请人： Roberto Burioni ,  Massimo Clementi

    发明人： Roberto Burioni ,  Massimo Clementi

    IPC分类号： A61K39/395 ,  C07K16/42 ,  C07K14/00 ,  C07H21/04 ,  A61P31/18 ,  C12N15/63 ,  C12N5/10 ,  G01N33/53 ,  C40B30/04 ,  C40B40/10

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/545 ,  A61K2039/55566 ,  C07K16/4225 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2740/16134

    摘要： Novel anti-idiotype monoclonal antibodies are described which are capable of specifically reacting with the idiotype of human anti-gp120 antibodies, of inhibiting the binding between the gp120 antigen and human anti-gp120 antibodies, and of evoking a neutralising anti-gp120 immune response in an animal host to which they are administered. The anti-idiotype antibodies of the invention can be identified based on the amino acid sequences of the variable portions of their light and heavy chains. In addition, a method for obtaining a panel of anti-idiotype monoclonal antibodies, expression vectors and transformed host cells usable in a recombinant DNA procedure in order to generate the aforesaid anti-idiotype monoclonal antibodies, as well as the therapeutic, prophylactic and diagnostic use of such antibodies are disclosed.

    摘要翻译： 描述了能够与人抗gp120抗体的独特型特异性反应，抑制gp120抗原与人抗gp120抗体之间的结合以及引起中和抗gp120免疫应答的新型抗独特型单克隆抗体 它们被施用的动物宿主。 可以基于其轻链和重链的可变部分的氨基酸序列鉴定本发明的抗独特型抗体。 此外，获得一组抗独特型单克隆抗体，表达载体和可用于重组DNA程序的转化宿主细胞以产生前述抗独特型单克隆抗体以及治疗，预防和诊断用途的方法 的这样的抗体。

    Anti-idiotypic monoclonal antibody reactive with HIV neutralizing antibody 2F5
    2.
    发明授权
    Anti-idiotypic monoclonal antibody reactive with HIV neutralizing antibody 2F5 失效
    与HIV中和抗体2F5反应的抗独特型单克隆抗体

    公开(公告)号：US07625566B2

    公开(公告)日：2009-12-01

    申请号：US10501726

    申请日：2003-01-17

    申请人： Renate Kunert ,  Robert Weik ,  Gabriela Stiegler ,  Hermann Katinger

    发明人： Renate Kunert ,  Robert Weik ,  Gabriela Stiegler ,  Hermann Katinger

    IPC分类号： A61K39/42 ,  C12N5/06 ,  C12P21/08

    CPC分类号： C07K16/4225 ,  A61K39/00 ,  A61K2039/505

    摘要： The invention relates to Ab2-type anti-idiotypic antibodies and fragments thereof which mimic HVI-1 epitopes that are otherwise cryptic to the immune system and which antibodies or fragments thereof are directed against potently neutralizing anti-HIV-1 antibodies. The invention further relates to a hybridoma cell line 3H6 expressing the anti-idiotypic antibody and to pharmaceutical compositions containing the antibody or fragment thereof. The invention also relates to HIV-1 neutralizing Ab3-type antibodies elicited upon administration of the Ab2-type anti-idiotypic antibody or fragment thereof and to pharmaceutical compositions containing them. The invention also relates to the use of the present antibodies or fragments thereof as screening tools or as diagnostic or therapeutic agents.

    摘要翻译： 本发明涉及Ab2型抗独特型抗体及其片段，其模拟HVI-1表位，否则其对于免疫系统是隐秘的，哪些抗体或其片段针对有效中和抗HIV-1抗体。 本发明还涉及表达抗独特型抗体的杂交瘤细胞系3H6和含有抗体或其片段的药物组合物。 本发明还涉及在施用Ab2型抗独特型抗体或其片段时引发的HIV-1中和Ab3型抗体以及含有它们的药物组合物。 本发明还涉及本发明的抗体或其片段作为筛选工具或诊断或治疗剂的用途。

    Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies
    3.
    发明申请
    Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies 失效
    编码单克隆抗体1F7的重链和轻链的可变区的核苷酸序列，与抗HIV抗体反应的抗独特型抗体

    公开(公告)号：US20030100741A1

    公开(公告)日：2003-05-29

    申请号：US09759112

    申请日：2001-01-11

    发明人： Sybille Muller ,  Heinz Kohler

    IPC分类号： A61K039/395 ,  C07K016/44 ,  C12P021/02 ,  C07H021/04 ,  C12N005/06

    CPC分类号： C07K16/4225 ,  C07K2317/24 ,  C07K2317/56

    摘要： Nucleotide sequences encoding the variable heavy and light chains of the murine monoclonal antibody 1F7 are disclosed. The 1F7 antibody is an effective immune modulator that has anti-idiotypic binding affinity for anti-HIV antibodies. Polypeptides containing at least one complementarity-determining region (CDR) or framework-determining region (FR) of the variable heavy or variable light chains of 1F7, as well as the polynucleotides encoding them, can be used to modulate the immune response to HIV infection. Unnecessary, and potentially adverse, murine segments of the variable chains falling outside the CDRs can be replaced with human sequences to afford humanized chimeric antibodies and antibody fragments.

    摘要翻译： 公开了编码鼠单克隆抗体1F7的可变重链和轻链的核苷酸序列。 1F7抗体是对抗HIV抗体具有抗独特型结合亲和力的有效的免疫调节剂。 含有1F7的可变重链或可变轻链的至少一个互补决定区（CDR）或框架决定区（FR）的多肽以及编码它们的多核苷酸可用于调节对HIV感染的免疫应答 。 落在CDR之外的可变链的不必要和潜在不利的鼠段可以用人序列替代，以提供人源化嵌合抗体和抗体片段。

    Anti-paratopic antibody as an immunogen
    7.
    发明授权
    Anti-paratopic antibody as an immunogen 失效
    抗副交叉抗体作为免疫原

    公开(公告)号：US06812024B2

    公开(公告)日：2004-11-02

    申请号：US09934114

    申请日：2001-08-22

    申请人： Roland Keith McGready

    发明人： Roland Keith McGready

    IPC分类号： C12N506

    CPC分类号： C07K16/4225 ,  A61K39/00 ,  C07K16/1045

    摘要： The present invention provides a method of manufacture of an anti-paratopic antibody comprising the steps of: (1) selecting from a pool of antibodies occurring in one species a prototypic set the members of which are effective in binding a specific antigen (or antigen epitope), and (2) utilizing one or more members of said prototypic set, or paratopic fragments thereof, as an immunogen in a host of a different species, or in an in vitro incubation system comprising cells derived from the same or a different species, to produce antibodies having a characteristic which is anti-paratopic with respect to said immunogen to produce a synthetic replicate of the specific antigen or epitope. Antigen (or antigen epitope), and monoclonal antibodies, vaccines and processes of immunization employing the product of the method of manufacture are also described.

    摘要翻译： 本发明提供了一种制备抗副替代抗体的方法，包括以下步骤：（1）从存在于一个物种中的抗体库中选择一个原型组，其成员在结合特异性抗原（或抗原表位 ），和（2）利用所述原型组或其副变构片段的一个或多个成员作为不同物种宿主中的免疫原，或在包含衍生自相同或不同物种的细胞的体外孵育系统中， 以产生具有相对于所述免疫原的抗副交叉特征的抗体，以产生特异性抗原或表位的合成重复。 还描述了使用制造方法的产物的抗原（或抗原表位）和单克隆抗体，疫苗和免疫方法。