Patent search cpc:"C07C217/24" Page 1

1.

发明授权
Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors 失效
Title translation: 烷氧基氨基取代的芴酮及其作为蛋白激酶C抑制剂的用途

公开(公告)号：US6004959A

公开(公告)日：1999-12-21

申请号：US844209

申请日：1997-04-18

Applicant: Winton D. Jones , Fred L. Ciske , Robert J. Dinerstein , Keith A. Diekema

Inventor： Winton D. Jones , Fred L. Ciske , Robert J. Dinerstein , Keith A. Diekema

IPC: C07C217/24 , C07C225/22 , C07D295/092 , A61K31/40 , A61K31/535 , C07D295/116

CPC classification number: C07D295/088 , C07C217/24 , C07C225/22 , C07C2103/18

Abstract: The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).

Abstract translation: 本发明描述了抑制蛋白激酶C的某些烷氧基氨基取代的芴酮，以及包括这些化合物的药物组合物以及使用这些化合物控制哺乳动物（包括人）中的蛋白激酶C活性的方法。更具体地，本发明化合物可用于治疗肿瘤性疾病状态，与异常血流（包括高血压，缺血，动脉粥样硬化，凝血障碍）和炎性疾病（包括免疫疾病，哮喘，肺纤维化和牛皮癣）相关的疾病，。

2.

发明授权
1-(cyclohex - 2' - en-4'-one)-2-phenyl- 1,2,3,4-tetrahydronaphthalene derivatives 失效
Title translation: 1-（CYCLOHEX-2'-EN-4'-ONE）-2-苯基-1,2,3,4-四氢萘基衍生物

公开(公告)号：US3520894A

公开(公告)日：1970-07-21

申请号：US3520894D

申请日：1966-08-22

Applicant: SYNTEX CORP

Inventor： CROSS ALEXANDER D

IPC: C07D295/088 , C07D307/20 , C07D317/72 , C07C49/76

CPC classification number: C07D295/088 , C07C49/683 , C07C49/697 , C07C49/753 , C07C217/24 , C07C2602/10 , C07D307/20 , C07D317/72

3.

发明申请
Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 失效

公开(公告)号：US20060084680A1

公开(公告)日：2006-04-20

申请号：US10537630

申请日：2003-12-19

Applicant: Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens

Inventor： Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens

IPC: A61K31/445 , A61K31/195 , A61K31/192

CPC classification number: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04

Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

4.

发明授权
Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for their production 失效
Title translation: 7-氧代-7H-苯并（c）芴的碱性醚及其制备方法

公开(公告)号：US4661297A

公开(公告)日：1987-04-28

申请号：US417834

申请日：1982-09-14

Applicant: Jiri Krepelka , Iva Vancurova , Karel Rezabek , Milan Melka , Vojtech Pujman , Stanislava Pokorna , Ruzena Reichlova , Slavjanka Cernochova

Inventor： Jiri Krepelka , Iva Vancurova , Karel Rezabek , Milan Melka , Vojtech Pujman , Stanislava Pokorna , Ruzena Reichlova , Slavjanka Cernochova

IPC: A61K31/135 , A61K20060101 , A61K31/085 , A61K31/13 , A61K31/205 , A61K31/65 , A61P35/00 , C07C20060101 , C07C13/567 , C07C43/21 , C07C67/00 , C07C213/00 , C07C217/24 , C07C93/06

CPC classification number: A61K31/13 , C07C217/24 , C07C2103/40

Abstract: Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.

Abstract translation: 已经显示7-氧代-7H-苯并（c）芴的碱性醚证明在患有白血病的哺乳动物中具有显着的抗肿瘤和免疫抑制作用。制备所述醚及其药学上可接受的有机酸和无机酸的加成盐的技术涉及5-羟基-7-氧代-7H-苯并（c）芴及其相应的核取代衍生物在羟基氧原子上的氨基烷基化。

5.

发明公开
5-HYDROXY-1,4-NAPHTHALENEDIONE FOR USE IN THE TREATMENT OF CANCER 审中-公开

公开(公告)号：US20240018132A1

公开(公告)日：2024-01-18

申请号：US18250738

申请日：2021-10-26

Applicant: GODAVARI BIOREFINERIES LIMITED

Inventor： Sandip GAVADE , Sangeeta SRIVASTAVA , Prashant KHARKAR , Maithili ATHAVALE

IPC: C07D413/12 , C07D317/64 , C07D265/30 , C07C235/10 , C07C217/24 , A61P35/00

CPC classification number: C07D413/12 , C07D317/64 , C07D265/30 , C07C235/10 , C07C217/24 , A61P35/00

Abstract: The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula (I) to (IV) for the treatment of cancer.

6.

发明授权
Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 失效

公开(公告)号：US07714004B2

公开(公告)日：2010-05-11

申请号：US10537630

申请日：2003-12-19

Applicant: Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens

Inventor： Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens

IPC: A61K31/426 , C07D277/20

CPC classification number: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04

Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

7.

发明授权
Substituted dibenz (A F)azulenes and methods of preparation 失效
Title translation: 取代的二苯并（A F）薁和制备方法

公开(公告)号：US5834521A

公开(公告)日：1998-11-10

申请号：US693861

申请日：1996-08-05

Applicant: John H. Dodd , Lisa A. Dixon , James L. Bullington , Charles F. Schwender

Inventor： John H. Dodd , Lisa A. Dixon , James L. Bullington , Charles F. Schwender

IPC: A61K31/015 , A61K31/03 , A61K31/04 , A61K31/085 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/215 , A61P13/02 , A61P15/00 , C07C13/66 , C07C23/46 , C07C25/22 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/225 , C07C43/23 , C07C49/755 , C07C49/84 , C07C65/26 , C07C69/00 , C07C69/157 , C07C69/65 , C07C69/734 , C07C205/20 , C07C205/37 , C07C205/42 , C07C211/61 , C07C217/16 , C07C217/24 , C07C233/07 , C07C233/11 , C07C233/15 , C07D257/04 , C07F9/12 , A61K31/09

CPC classification number: C07D257/04 , C07C13/66 , C07C205/20 , C07C205/37 , C07C205/42 , C07C211/61 , C07C217/24 , C07C233/07 , C07C233/15 , C07C25/22 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/225 , C07C43/23 , C07C49/755 , C07C49/84 , C07C65/26 , C07C69/017 , C07C69/157 , C07C69/16 , C07C69/63 , C07F9/12 , C07C2103/40

Abstract: Tetracyclic compounds having the following structure are described: ##STR1## wherein R.sub.1 -R.sub.10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antiovulatory effects and potent steroid receptor binding. The compounds have therapeutic utility in reproductive applications such as fertility control, labor induction, ovulation induction and spermatogenesis. Methods for preparing the tetracyclic compounds from substituted indanones are also described.

Abstract translation: 描述具有以下结构的四环化合物：其中R 1 -R 10如上所定义。四环化合物能够对类固醇敏感组织产生有效的作用，并且已经证明子宫重量增加，抗疟药效应和有效的类固醇受体结合。这些化合物在繁殖应用中具有治疗效用，例如生育控制，劳动诱导，排卵诱导和精子发生。还描述了从取代的茚满酮制备四环化合物的方法。