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    Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
    2.
    发明授权
    Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors 失效
    烷氧基氨基取代的芴酮及其作为蛋白激酶C抑制剂的用途

    公开(公告)号：US6004959A

    公开(公告)日：1999-12-21

    申请号：US844209

    申请日：1997-04-18

    申请人： Winton D. Jones ,  Fred L. Ciske ,  Robert J. Dinerstein ,  Keith A. Diekema

    发明人： Winton D. Jones ,  Fred L. Ciske ,  Robert J. Dinerstein ,  Keith A. Diekema

    IPC分类号： C07C217/24 ,  C07C225/22 ,  C07D295/092 ,  A61K31/40 ,  A61K31/535 ,  C07D295/116

    CPC分类号： C07D295/088 ,  C07C217/24 ,  C07C225/22 ,  C07C2103/18

    摘要： The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).

    摘要翻译： 本发明描述了抑制蛋白激酶C的某些烷氧基氨基取代的芴酮，以及包括这些化合物的药物组合物以及使用这些化合物控制哺乳动物（包括人）中的蛋白激酶C活性的方法。 更具体地，本发明化合物可用于治疗肿瘤性疾病状态，与异常血流（包括高血压，缺血，动脉粥样硬化，凝血障碍）和炎性疾病（包括免疫疾病，哮喘，肺纤维化和牛皮癣）相关的疾病， 。