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公开(公告)号：US20240300123A1
公开(公告)日：2024-09-12
申请号：US18262162
申请日：2022-01-20
CPC分类号： B25J21/005 , B25J5/02 , B65B3/003 , B65B7/2821 , B65B43/46 , B65B55/025 , A61J1/16
摘要： A machine for the preparation of pharmaceutical products in a sterile environment, including at least two stations of a line for preparing pharmaceutical products and automatic transport means for containers of pharmaceutical products, wherein the machine includes a robot positioned inside the machine and robot control means, the robot being a robotic arm which includes movement means for accessing the stations of the machine.
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公开(公告)号：US20240150050A1
公开(公告)日：2024-05-09
申请号：US18412182
申请日：2024-01-12
发明人： Nick BROADBENT , Jeroen IMMERZEEL , Christopher PROCYSHYN , Ross M. GOLD , Steve Sang Joon PARK
CPC分类号： B65B7/161 , B65B3/003 , B65B7/2821 , B65B55/027 , B65D41/28 , B65B55/08
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号：US11939099B2
公开(公告)日：2024-03-26
申请号：US17876155
申请日：2022-07-28
发明人： Gwenn Le Dimet , Julien Gagliano
CPC分类号： B65B67/02 , A61M5/31 , B65B7/2821 , B65B31/027 , B65B31/047 , B65B59/003 , A61M2207/00 , A61M2207/10
摘要： The invention relates to a device for vacuum stoppering a medical container. The device includes a main body defining an internal volume that has a variable pressure chamber configured to be connected to a vacuum pump. A stopper holder system is arranged in communication with the variable pressure chamber and is configured to receive and hold a stopper aligned with the direction of travel of a piston rod. A piston rod is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position wherein the piston rod pushes the stopper into the medical container. A container holder system provided in the main body, is arranged distally relative to the stopper holder system and in communication with the variable pressure chamber.
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公开(公告)号：US20240002085A1
公开(公告)日：2024-01-04
申请号：US18253338
申请日：2021-11-19
发明人： Markus Ilgenfritz , Ulrich Krauß , Stefan Nagler
CPC分类号： B65B7/2821 , B65B57/02
摘要： The invention relates to a device (10) for closing pharmaceutical containers (18) by means of closures (22), having a first holding device (12) for receiving at least one pharmaceutical container (18), a second holding device (14) for receiving at least one closure (22) for closing an opening (24) of the pharmaceutical container (18), wherein the two holding devices (12, 14) are mutually alignable, or are mutually aligned, in such a way that the closure (22) and the opening (24) of the container (18) are aligned with one another, wherein a plunger (34) and a counter element (40) are provided, wherein the plunger (34) and/or the counter element (40), by means of a drive device (36), can be driven and, relative to one another, moved, wherein, when the plunger (34) and the counter element (40) are moved towards one another when the drive device (36, 42) is driven, the plunger (34) acts on the closure (22) or on the container (18) in such a way that the closure (22) can come into contact with the container (18) and, in order to close the opening (24) of the container (18), can be pressed onto the container (18) by the cooperation of the plunger (34) and the counter element (40), wherein a force sensor (44) is provided, by means of which a force applied by the closure plunger (34) when the closure (22) is pressed onto the container (18) can be detected.
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公开(公告)号：US20230201467A1
公开(公告)日：2023-06-29
申请号：US17927264
申请日：2021-05-20
发明人： Robert Basham , Nicole Dupuy , Erik Larose
CPC分类号： A61M5/31513 , A61M5/3129 , A61M5/1782 , B65B7/2821 , A61M2005/3131
摘要： A method of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a hybrid insertion device, (2) lowering the body of the hybrid insertion device into a syringe barrel or cartridge tube to a position located past the barrel flange or top of the cartridge tube while stablishing a sealable connection with the syringe barrel or cartridge tube, (3) maneuvering the stopper past the distal opening of the hybrid insertion device using an insertion pin and deploying the stopper at a final position within the syringe barrel or cartridge tube under vacuum assistance, (4) fully retracting the insertion pin from the syringe barrel or cartridge tube, and (5) retracting the hybrid insertion device from syringe barrel or cartridge tube. The method is lubricant free or substantially lubricant free. The hybrid insertion device may be electropolished and/or extrude honed.
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公开(公告)号：US20230157927A1
公开(公告)日：2023-05-25
申请号：US17992412
申请日：2022-11-22
申请人： CORNING INCORPORATED
CPC分类号： A61J1/1412 , A61J1/065 , A61J1/1468 , B65B7/2821 , B65D41/28
摘要： Caps for sealing assemblies for sealing glass containers and maintaining container closure integrity at −80° C. or less are disclosed. The caps include a cap skirt having an annular body and a crimp region. The crimp region is a crimpable metal. The annular body of the cap skirt has a coefficient of thermal expansion (CTE) greater than a CTE of a metal consisting of aluminum, a stiffness greater than or equal to 2 times a stiffness of the crimp region, or both. The greater CTE, stiffness, or both of the cap skirt increase the seal pressure and contact area between the stopper and glass container when cooled to −80° C. or less. The caps enable the sealing assemblies to maintain a helium leakage rate of the sealed glass container of less than or equal to 1.4×10−6 cm3/s at −80° C. or less.
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公开(公告)号：US20180304012A1
公开(公告)日：2018-10-25
申请号：US15758890
申请日：2015-09-11
发明人： Hubert JANSEN
CPC分类号： A61M5/1782 , A61M2005/3123 , B65B3/006 , B65B7/2821
摘要： A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.
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公开(公告)号：US20180200202A1
公开(公告)日：2018-07-19
申请号：US15405877
申请日：2017-01-13
发明人： Vijay Joguparthi , Rosario LoBrutto
IPC分类号： A61K31/137 , A61K47/12 , A61K47/02 , A61L31/02 , A61L31/04 , A61L31/16 , A61M5/31 , A61M5/315 , A61M5/34 , A61M5/20 , A61M5/32
CPC分类号： A61K31/137 , A61K9/0019 , A61K47/02 , A61K47/12 , A61L31/022 , A61L31/026 , A61L31/048 , A61L31/16 , A61M5/2033 , A61M5/3129 , A61M5/31591 , A61M5/3243 , A61M5/329 , A61M5/349 , A61M2005/2026 , A61M2205/02 , A61M2207/00 , B65B3/003 , B65B7/2821 , B65B55/14 , B65B55/16 , C09J175/04 , C09J175/16
摘要： The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device. The pre-filled syringe comprises a container and a needle. The container is filled with a pharmaceutical composition comprising epinephrine, a buffer, and water. The buffer is configured to buffer in a pH range between 3 and 4. The needle is adhered to the container by means of a urethane acrylate or urethane methacrylate acrylic light cure adhesive, which is configured to provide a pull out resistance of the needle relative to the container which is between 30 N to 100 N, preferably between 50 N to 70 N, more preferably greater than 60 N after 90 days exposure to the pharmaceutical composition at 40° C. and 75% relative humidity (RH). In an example, the pharmaceutical composition is for the treatment of an anaphylactic event.
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公开(公告)号：US20180155094A1
公开(公告)日：2018-06-07
申请号：US15821348
申请日：2017-11-22
申请人： Stefan Loukov
发明人： Stefan Loukov
CPC分类号： B65D50/062 , B65B7/2821 , B65D41/485 , B65D47/0838 , B65D55/16 , B65D2101/0076
摘要： A closure is provided for a container. The closure includes a base having a substantially cylindrical shape with a recessed area along a top perimeter of the base. The closure also includes a lid configured to close over and open off of the base. The closure further includes a tab that extends from a lower surface of the lid and includes a lip portion configured to fold back onto the tab and lock with the base when the lid is closed over the base. The tab detaches from the lid when opening the lid from the base after the lip portion is folded back onto the tab. A portion of the outer surface of the tab is visible through the at least one recessed area after the lid is closed over the base and remains partially visible after the tab has detached from the lid.
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公开(公告)号：US20180127120A1
公开(公告)日：2018-05-10
申请号：US15719736
申请日：2017-09-29
发明人： Nick BROADBENT , Jeroen IMMERZEEL , Christopher PROCYSHYN , Ross M. GOLD , Steve Sang Joon PARK
IPC分类号： B65B7/16 , B65D51/00 , B65D1/02 , B65B7/28 , B65B3/00 , B65B55/04 , B65B63/08 , B65B55/10 , B65B55/08 , B65B55/02
CPC分类号： B65B7/28 , B65B3/003 , B65B7/161 , B65B7/2821 , B65B55/027 , B65B55/04 , B65B55/08 , B65B55/10 , B65B63/08 , B65D1/0246 , B65D51/00 , B65D51/002
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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