Hollow/porous fibers and applications thereof
    2.
    发明授权
    Hollow/porous fibers and applications thereof 有权
    空心/多孔纤维及其应用

    公开(公告)号:US09585422B2

    公开(公告)日:2017-03-07

    申请号:US13863920

    申请日:2013-04-16

    摘要: In one embodiment is provided a polymer blend of poly(vinyl acetate) (PVAc) and poly(acrylic acid) (PAA), wherein the poly(vinylacetate) is present in an amount ranging between about 20 wt % and about 80 wt %, and poly(acrylic acid) is present in an amount ranging between about 80 wt % and about 20 wt %, based on the total weight of the blend. In another embodiment is provided a fiber produced from this polymer blend, and which has cells therein. In another embodiment is provided a flavorant release material comprising the porous fiber disclosed herein, and one or more flavorants disposed in a longitudinally extending core within the fiber. In another embodiment is provided a polymer fiber membrane containing a hollow, porous fiber formed from the polymer blend disclosed herein. In another embodiment is provided a filter containing the fiber described herein. In another embodiment is provided a process for producing the fibers disclosed herein by addition of the polymers to an extruder or blender, and extruding or melt spinning the mixture into a fiber containing cells therein.

    摘要翻译: 在一个实施方案中提供聚(乙酸乙烯酯)(PVAc)和聚(丙烯酸)(PAA)的聚合物共混物,其中聚(乙酸乙烯酯)以约20重量%至约80重量% 并且基于共混物的总重量,聚(丙烯酸)以约80重量%至约20重量%的量存在。 在另一个实施方案中提供了由该聚合物共混物制备的纤维,并且其中具有细胞。 在另一个实施方案中,提供了包含本文公开的多孔纤维的调味剂释放材料和设置在纤维内的纵向延伸的芯中的一种或多种调味剂。 在另一个实施方案中提供了含有由本文公开的聚合物共混物形成的中空多孔纤维的聚合物纤维膜。 在另一个实施方案中,提供了包含本文所述的纤维的过滤器。 在另一个实施方案中提供了通过将聚合物加入到挤出机或混合器中制备本文公开的纤维的方法,并将混合物挤出或熔融纺丝成其中含有细胞的纤维。

    Charged hollow fiber membrane having hexagonal voids
    3.
    发明授权
    Charged hollow fiber membrane having hexagonal voids 有权
    具有六边形空隙的充电中空纤维膜

    公开(公告)号:US09561473B2

    公开(公告)日:2017-02-07

    申请号:US14193784

    申请日:2014-02-28

    申请人: PALL CORPORATION

    摘要: Disclosed is a charged hollow fiber membrane having hexagonal voids for use in high throughput applications. The membrane includes: (i) an inner surface; (ii) an outer surface; (iii) a porous bulk disposed therebetween, wherein the porous bulk comprises at least a first region including: a) a first set of pores having a controlled pore size and having outer rims; b) a second set of pores connecting the outer rims of the first set of pores, wherein the pore size of the first set of pores is greater than the pore size of the second set of pores; and c) a polymer matrix supporting the first set of pores; and (iv) at least one charged zone disposed on the inner surface, on the outer surface, and/or in the porous bulk hollow fiber membrane. Also disclosed is a method for preparing such hollow fiber membranes, which involves coating a filament with a coating composition that includes a membrane-forming polymer, a charged polymer, and dissolvable nanoparticles, followed by phase invention, dissolving of the nanoparticles, and removal of the filament.

    摘要翻译: 公开了一种具有六角形空隙的带电中空纤维膜,用于高通量应用。 膜包括:(i)内表面; (ii)外表面; (iii)设置在其间的多孔体,其中所述多孔体包括至少第一区域,所述第一区域包括:a)具有受控孔径且具有外缘的第一组孔; b)连接第一组孔的外缘的第二组孔,其中第一组孔的孔径大于第二组孔的孔径; 和c)支撑第一组孔的聚合物基质; 和(iv)设置在内表面,外表面和/或多孔体中空纤维膜中的至少一个带电区。 还公开了一种制备这种中空纤维膜的方法,其包括用包含成膜聚合物,带电聚合物和可溶性纳米颗粒的涂料组合物涂覆长丝,然后进行相变,纳米颗粒的溶解和除去 灯丝。

    SERVICEABLE BIOREACTOR
    4.
    发明申请
    SERVICEABLE BIOREACTOR 有权
    可维修的生物工程师

    公开(公告)号:US20140310932A2

    公开(公告)日:2014-10-23

    申请号:US13863123

    申请日:2013-04-15

    IPC分类号: B01D65/02 B01D67/00

    摘要: The invention resides in an apparatus for treatment of a substance. The apparatus has a substance tube for enabling a substance to be treated to pass in to the substance tube via the substance-inlet and out of the substance tube through the substance-outlet. The apparatus also has a cleaning chamber, wherein the substance tube is configured in fluid communication with the cleaning chamber to enable a substance to diffuse the permeable membrane between the substance tube and the cleaning chamber such that a substance can be substantially cleaned by a cleaner, the substance comprising blood or plasma and the cleaner comprising a cell culture. The substance tube is removably connectable with the cleaning chamber for inter-changeability or serviceability. The apparatus can further comprise a support compartment configured to connect to, or enclosing, the cleaning chamber, which functions to carry a fluid to substantially maintain the functionality of the cleaner.

    摘要翻译: 本发明在于用于处理物质的装置。 该装置具有用于使物质被处理的物质管通过物质入口通过物质出口通过物质管进入物质管。 该设备还具有清洁室,其中物质管被构造成与清洁室流体连通,以使物质能够将物质管道和清洁室之间的渗透膜扩散,使得物质可以被清洁器基本上清洁, 包含血液或血浆的物质和包含细胞培养物的清洁剂。 物质管可拆卸地与清洁室连接,用于互换性或适用性。 该装置还可以包括配置成连接到清洁室或包围清洁室的支撑室,其用于承载流体以基本上保持清洁器的功能。

    Antisolvent crystallization in porous hollow fiber devices and methods of use thereof
    7.
    发明申请
    Antisolvent crystallization in porous hollow fiber devices and methods of use thereof 有权
    多孔中空纤维装置中的抗溶剂结晶及其使用方法

    公开(公告)号:US20070289105A1

    公开(公告)日:2007-12-20

    申请号:US11811557

    申请日:2007-06-11

    IPC分类号: C13K1/10

    摘要: Antisolvent crystallization systems and methods are provided that employ porous hollow fiber membranes. The porous hollow fiber membrane includes a plurality of porous hollow fibers positioned within a shell, each porous hollow fiber defining a lumen side and shell side. A crystallizing solution is introduced to one side of the hollow fibers and an antisolvent is introduced to the other side of the fibers, in either cocurrent or countercurrent flow. One of the antisolvent and the crystallizing solution permeates in part through the porous hollow fiber membrane to the other side and crystals are formed thereby. Permeation of the antisolvent or the crystallizing solution establishes advantageous radial mixing that facilitates crystal formation of a desired size distribution. Downstream mixing, e.g., a completely stirred tank or a static mixer, may be employed to further improve crystallization operations.

    摘要翻译: 提供了使用多孔中空纤维膜的抗溶剂结晶体系和方法。 多孔中空纤维膜包括位于壳内的多个多孔中空纤维,每个多孔中空纤维限定内腔侧和外壳侧。 将结晶溶液引入中空纤维的一侧,并将反溶剂以并流或逆流流入纤维的另一侧。 反溶剂和结晶溶液中的一种通过多孔中空纤维膜渗透到另一侧,由此形成晶体。 反溶剂或结晶溶液的渗透产生有利的径向混合,其有利于所需尺寸分布的晶体形成。 可以使用下游混合,例如完全搅拌的罐或静态混合器,以进一步改善结晶操作。

    Hollow fiber for dialysis and process of manufacturing
    8.
    发明授权
    Hollow fiber for dialysis and process of manufacturing 失效
    中空纤维用于透析和制造过程

    公开(公告)号:US5505859A

    公开(公告)日:1996-04-09

    申请号:US196100

    申请日:1994-02-17

    摘要: A dialysis membrane is made of a regenerated cellulose polymer in the form of a hollow fiber with a continuous internal cavity filled essentially with a gas. The hollow fiber has a porous inner and an outer surface. The outer surface of the hollow fiber is formed by a thin skin which has fine lengthwise grooves. The inner surface of the hollow fiber is positively modified by physical and/or chemical means.The invention also includes a method for manufacturing such a dialysis membrane.

    摘要翻译: PCT No.PCT / EP92 / 01801 Sec。 371日期1994年2月17日 102(e)日期1994年2月17日PCT提交1992年8月7日PCT公布。 出版物WO93 / 03829 日期1993年3月4日。透析膜由中空纤维形式的再生纤维素聚合物制成,其具有基本上充满气体的连续内腔。 中空纤维具有多孔的内表面和外表面。 中空纤维的外表面由具有细长纵向槽的薄皮形成。 中空纤维的内表面通过物理和/或化学方式积极修饰。 本发明还包括制造这种透析膜的方法。