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    MEMBRANE HOLDER AND MEMBRANE MODULE
    2.
    发明公开
    MEMBRANE HOLDER AND MEMBRANE MODULE 审中-公开

    公开(公告)号：US20240238730A1

    公开(公告)日：2024-07-18

    申请号：US18559463

    申请日：2022-05-05

    申请人： NX Filtration B.V.

    发明人： Hendrik Johan Ferdinand Berends

    IPC分类号： B01D63/04

    CPC分类号： B01D63/04 ,  B01D2313/025 ,  B01D2313/08

    摘要： A membrane holder for hollow fibre membranes, in particular for applying in a tube filter, includes a central pipe having spaced apart bands of inlet openings formed along a circumference of the central pipe to flow liquid through the central pipe, holding elements arranged around the central pipe, which holding elements have radially extending wall parts distributed along the circumference of the central pipe, and closing parts extending between the free ends of the radially extending wall parts for confining a bundle of hollow fibre membranes between two adjacent radially extending wall parts and a closing part, and deflector plates concentrically arranged around and spaced apart from the central pipe and, when viewed in radial direction, covering the bands of inlet openings.

    ISOLATION AND PURIFICATION METHOD OF EXTRACELLULAR VESICLES
    4.
    发明公开
    ISOLATION AND PURIFICATION METHOD OF EXTRACELLULAR VESICLES 审中-公开

    公开(公告)号：US20240238728A1

    公开(公告)日：2024-07-18

    申请号：US18562135

    申请日：2022-05-24

    申请人： DAICEN MEMBRANE-SYSTEMS Ltd. ,  Daicel Corporation

    发明人： Shuji NAKATSUKA ,  Seiichi UCHIMURA ,  Takahiro OCHIYA ,  Yusuke YOSHIOKA

    IPC分类号： B01D61/14 ,  B01D63/04 ,  B01D69/02 ,  B01D69/08 ,  C12N5/0775

    CPC分类号： B01D61/1471 ,  B01D63/04 ,  B01D69/02 ,  B01D69/08 ,  C12N5/0667 ,  B01D2325/02833 ,  B01D2325/02834 ,  B01D2325/34

    摘要： [Object]
    To provide an isolation and purification method for isolating and purifying extracellular vesicles.
    [Solution]
    An isolation and purification method of extracellular vesicles is disclosed. A hollow fiber membrane has an inner diameter of 0.2 mm to 1.4 mm and a molecular weight cut-off of 100000 to 1000000. Filtering includes a first filtration process of press-fitting the culture supernatant of the mesenchymal stem cells from a first opening on one end side of the hollow fiber membrane and filtering the culture supernatant to separate the culture supernatant into a permeate and a first concentrate, and a second filtration process of press-fitting the first concentrate from a second opening on the other end side of the hollow fiber membrane and filtering the first concentrate to separate the first concentrate into a permeate and a second concentrate. A concentrate is produced in which a concentration of the extracellular vesicles is increased by alternating tangential flow filtration in which the first filtration process and the second filtration process are alternately performed a plurality of times. A membrane surface velocity in the first filtration process and the second filtration process is 0.3 m/sec to 2 m/sec.

    HOLLOW FIBER MEMBRANE MODULE
    5.
    发明公开
    HOLLOW FIBER MEMBRANE MODULE 审中-公开

    公开(公告)号：US20240198289A1

    公开(公告)日：2024-06-20

    申请号：US18288440

    申请日：2022-04-15

    申请人： NOK CORPORATION

    发明人： Matsuyoshi YAMASHITA ,  Yosuke ITO ,  Tsuyoshi EMOTO

    IPC分类号： B01D63/04 ,  B01D63/02

    CPC分类号： B01D63/04 ,  B01D63/0233

    摘要： A hollow fiber membrane module having: a tubular case; a plurality of hollow fiber membranes disposed within the case; sealing and fixing parts that fix the hollow fiber membranes to each other at the ends of the plurality of hollow fiber membranes; and sealing parts that seal annular gaps between the case and the sealing and fixing parts. The sealing parts are bonded to the inner peripheral surface of the case and the outer peripheral surface of the sealing and fixing parts while being allowed to expand or contract in the direction in which the spacing of the gaps between the case and the sealing and fixing parts changes.