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公开(公告)号：US09993436B2
公开(公告)日：2018-06-12
申请号：US14968456
申请日：2015-12-14
发明人： Kamalesh Sirkar , Robert Pfeffer , Dengyue Chen , Dhananjay Singh
IPC分类号： A61K9/50 , A61K31/343 , A61K9/00
CPC分类号： A61K9/5089 , A61K9/0092 , A61K9/5026 , A61K9/5031 , A61K31/343
摘要： Using porous hollow fiber membranes, systems/methods for continuously synthesizing polymer-coated particles by anti-solvent crystallization are provided. The disclosed systems/methods provide for synthesis of polymer-coated drug particles/crystals from solutions of the polymer and the drug particles in suspension by exposing the solution to an anti-solvent through a porous hollow fiber device. A feed solution of a coating polymer with suspended drug particles can be exposed to an anti-solvent through hollow fiber pores, thereby causing the polymer to precipitate on and coat the drug particles. In addition, a feed solution of a coating polymer with drug in solution can be exposed to an anti-solvent through hollow fiber pores, thereby causing the drug to crystallize from the solution and the polymer to precipitate/coat the drug. Results indicate that a uniformly coated, free-flowing product may be developed in this advantageous porous hollow fiber anti-solvent crystallization method. The coated drug particles can be used for controlled release of the drug, and the molecule and the crystal structure are not affected by the process.
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公开(公告)号：US20230405488A1
公开(公告)日：2023-12-21
申请号：US18241405
申请日：2023-09-01
发明人： Kamalesh Sirkar
IPC分类号： B01D9/00 , C07C213/06 , C07C213/10 , B01D61/28 , B01D11/04 , C07D403/06 , B01D9/02
CPC分类号： B01D9/0059 , C07C213/06 , C07C213/10 , B01D61/28 , B01D11/0492 , C07D403/06 , B01D9/02 , B01D2009/0086
摘要： The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.
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公开(公告)号：US20230027017A1
公开(公告)日：2023-01-26
申请号：US17857580
申请日：2022-07-05
发明人： Kamalesh Sirkar , Lydia Rodrigues
IPC分类号： B01D61/24 , B01D69/12 , B01D69/08 , B01D69/06 , B01D69/02 , B01D71/34 , B01D71/36 , B01D71/26 , B01D71/56 , B01D71/52 , B01D67/00 , B01D11/04
摘要： An example porous composite membrane for solvent extraction is provided. The porous composite membrane includes a Janus membrane with a first side and a second side opposing the first side. The first side exhibits hydrophobic characteristics and the second side exhibits hydrophilic characteristics. At least one of the first side or the second side is sized to perform nondispersive membrane solvent extraction.
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4.发明公开公开(公告)号：US20230149855A1
公开(公告)日：2023-05-18
申请号：US18085724
申请日：2022-12-21
发明人： Kamalesh Sirkar , Dhananjay Singh , Lin Li , Thomas J. McEvoy
CPC分类号： B01D61/366 , B01D61/364 , B01D63/04 , C02F1/447 , B01D2313/10 , B01D2313/12 , B01D2313/21 , B01D2315/10 , B01D2325/38 , C02F2103/08
摘要： Exemplary embodiments in desalination by direct contact membrane distillation present a cylindrical cross-flow module containing high-flux composite hydrophobic hollow fiber membranes. The present embodiments are directed to a model that has been developed to describe the observed water production rates of such devices in multiple brine feed introduction configurations. The model describes the observed water vapor production rates for different feed brine temperatures at various feed brine flow rates. The model flux predictions have been explored over a range of hollow fiber lengths to compare the present results with those obtained earlier from rectangular modules which had significantly shorter hollow fibers.
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公开(公告)号：US20220176270A1
公开(公告)日：2022-06-09
申请号：US17546305
申请日：2021-12-09
发明人： Kamalesh Sirkar
IPC分类号： B01D9/00 , C07C213/06 , C07C213/10 , B01D9/02 , B01D61/28 , B01D11/04 , C07D403/06
摘要： The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.
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公开(公告)号：US09452930B2
公开(公告)日：2016-09-27
申请号：US14532663
申请日：2014-11-04
发明人： Kamalesh Sirkar , Robert Pfeffer , Dhananjay Singh , Dengyue Chen
CPC分类号： B82Y30/00 , A61K9/50 , A61K9/5192
摘要： The present disclosure relates to the field of polymer coating. The present disclosure provides improved systems and methods for continuous polymer coating of particles (e.g., nanoparticles). The present disclosure provides for a solid hollow fiber cooling crystallization (SHFCC) technique to continuously coat the nanoparticles with polymer. In certain embodiments, the present disclosure embraces continuous coating of particles from about 1 nm to about 10 microns. A polymer solution containing a suspension of submicron particles flows in the lumen of a solid polymeric hollow fiber, and controlled cooling of the polymer solution allows for polymer nucleation on the surface of the particles, and the precipitated polymer forms a thin film around the particles (the thickness of which can be varied depending on the operating conditions). The systems, methods and assemblies of the present disclosure are easily adaptable for coating nano-sized drug particles as well.
摘要翻译： 本公开涉及聚合物涂层领域。 本公开提供了用于颗粒（例如纳米颗粒）的连续聚合物涂覆的改进的系统和方法。 本公开提供了用聚合物连续涂覆纳米颗粒的固体中空纤维冷却结晶（SHFCC）技术。 在某些实施方案中，本发明包括约1nm至约10微米的颗粒的连续包衣。 含有亚微米颗粒悬浮液的聚合物溶液在固体聚合物中空纤维的内腔中流动，并且聚合物溶液的受控冷却允许在颗粒表面上聚合物成核，并且沉淀的聚合物在颗粒周围形成薄膜（ 其厚度可以根据操作条件而变化）。 本公开的系统，方法和组件也容易适用于涂覆纳米尺寸药物颗粒。
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公开(公告)号：US12121860B2
公开(公告)日：2024-10-22
申请号：US18085724
申请日：2022-12-21
发明人： Kamalesh Sirkar , Dhananjay Singh , Lin Li , Thomas J. McEvoy
IPC分类号： B01D61/36 , B01D63/02 , B01D63/04 , C02F1/44 , C02F103/08
CPC分类号： B01D61/366 , B01D61/3641 , B01D63/02 , B01D63/04 , C02F1/447 , B01D2313/10 , B01D2313/12 , B01D2313/21 , B01D2315/10 , B01D2325/38 , C02F2103/08
摘要： Exemplary embodiments in desalination by direct contact membrane distillation present a cylindrical cross-flow module containing high-flux composite hydrophobic hollow fiber membranes. The present embodiments are directed to a model that has been developed to describe the observed water production rates of such devices in multiple brine feed introduction configurations. The model describes the observed water vapor production rates for different feed brine temperatures at various feed brine flow rates. The model flux predictions have been explored over a range of hollow fiber lengths to compare the present results with those obtained earlier from rectangular modules which had significantly shorter hollow fibers.
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公开(公告)号：US11534720B2
公开(公告)日：2022-12-27
申请号：US16607015
申请日：2018-04-23
发明人： Kamalesh Sirkar , Dhananjay Singh , Lin Li , Thomas J. McEvoy
IPC分类号： B01D61/36 , B01D63/04 , C02F1/44 , C02F103/08
摘要： Exemplary embodiments in desalination by direct contact membrane distillation present a cylindrical cross-flow module containing high-flux composite hydrophobic hollow fiber membranes. The present embodiments are directed to a model that has been developed to describe the observed water production rates of such devices in multiple brine feed introduction configurations. The model describes the observed water vapor production rates for different feed brine temperatures at various feed brine flow rates. The model flux predictions have been explored over a range of hollow fiber lengths to compare the present results with those obtained earlier from rectangular modules which had significantly shorter hollow fibers.
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公开(公告)号：US20150125590A1
公开(公告)日：2015-05-07
申请号：US14532663
申请日：2014-11-04
发明人： Kamalesh Sirkar , Robert Pfeffer , Dhananjay Singh , Dengyue Chen
IPC分类号： A61K9/14
CPC分类号： B82Y30/00 , A61K9/50 , A61K9/5192
摘要： The present disclosure relates to the field of polymer coating. The present disclosure provides improved systems and methods for continuous polymer coating of particles (e.g., nanoparticles). The present disclosure provides for a solid hollow fiber cooling crystallization (SHFCC) technique to continuously coat the nanoparticles with polymer. In certain embodiments, the present disclosure embraces continuous coating of particles from about 1 nm to about 10 microns. A polymer solution containing a suspension of submicron particles flows in the lumen of a solid polymeric hollow fiber, and controlled cooling of the polymer solution allows for polymer nucleation on the surface of the particles, and the precipitated polymer forms a thin film around the particles (the thickness of which can be varied depending on the operating conditions). The systems, methods and assemblies of the present disclosure are easily adaptable for coating nano-sized drug particles as well.
摘要翻译： 本公开涉及聚合物涂层领域。 本公开提供了用于颗粒（例如纳米颗粒）的连续聚合物涂覆的改进的系统和方法。 本公开提供了用聚合物连续涂覆纳米颗粒的固体中空纤维冷却结晶（SHFCC）技术。 在某些实施方案中，本发明包括约1nm至约10微米的颗粒的连续包衣。 含有亚微米颗粒悬浮液的聚合物溶液在固体聚合物中空纤维的内腔中流动，并且聚合物溶液的受控冷却允许在颗粒表面上的聚合物成核，并且沉淀的聚合物在颗粒周围形成薄膜（ 其厚度可以根据操作条件而变化）。 本公开的系统，方法和组件也容易适用于涂覆纳米尺寸药物颗粒。
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公开(公告)号：US20240116007A1
公开(公告)日：2024-04-11
申请号：US18377482
申请日：2023-10-06
发明人： Kamalesh Sirkar , Yufeng Song
IPC分类号： B01D69/14 , B01D15/10 , B01D53/04 , B01D53/22 , B01D63/04 , B01D69/02 , B01D69/08 , B01D71/02
CPC分类号： B01D69/147 , B01D15/10 , B01D53/04 , B01D53/229 , B01D63/04 , B01D69/02 , B01D69/08 , B01D71/028 , B01D2253/204 , B01D2325/12
摘要： A module for gas and/or vapor removal from a fluid stream is provided. The module includes at least one hollow fiber membrane including a first end and an opposing second end. The hollow fiber membrane includes a fiber wall defining an interior bore extending from the first end to the opposing second end and defining a passage for fluid flow through the hollow fiber membrane. The module includes a bed of metal organic framework (MOF) integrated into membrane pores of the fiber wall of the at least one hollow fiber membrane, into the hollow fiber membrane bore, and/or outside of the at least one hollow fiber membrane in an extracapillary space.
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