公开(公告)号：US20240293606A1

公开(公告)日：2024-09-05

申请号：US18418514

申请日：2024-01-22

申请人： VACURE Ltd.

发明人： Michael Bortz ,  Adam Sagiv ,  Oded Meiri ,  Petros Benias ,  Mitchell Roslin

IPC分类号： A61M1/00

CPC分类号： A61M1/84 ,  A61M2205/0216 ,  A61M2205/0266 ,  A61M2210/1042

摘要： A medical system for applying negative pressure within a gastrointestinal tract of a subject. The medical system includes an elongate tube defining at least one interior channel, a plurality of orifices in fluid communication with the interior channel, and at least one exterior channel. The exterior channel is in fluid communication with the interior channel via at least one of the orifices. The elongate tube has a delivery state, and a first operative state in which the elongate tube forms a coil including a plurality of loops. A fluid-tight lumen is in fluid communication with the elongate tube. The lumen is adapted to couple to a source of negative pressure for delivery of negative pressure to the elongate tube. In the first operative state of the elongate tube, a length of the coil is at least 15 mm and the plurality of loops includes at least 4 loops.

公开(公告)号：US20240189556A1

公开(公告)日：2024-06-13

申请号：US18530544

申请日：2023-12-06

申请人： BOSTON SCIENTIFIC SCIMED, INC.

发明人： Scott Edward Corbeil ,  Barry Weitzner

IPC分类号： A61M29/02 ,  A61B1/273 ,  A61B1/32 ,  A61B18/14 ,  A61M5/00 ,  A61M25/00

CPC分类号： A61M29/02 ,  A61B1/273 ,  A61B1/32 ,  A61B18/1485 ,  A61M5/007 ,  A61M25/0043 ,  A61B2018/00601 ,  A61B2018/144 ,  A61M2206/12 ,  A61M2210/1042 ,  A61M2210/1057

摘要： A fluid delivery device and system configured to regulate delivery of fluid through a fluid delivery port to a target site within a patient, such as to identify, locate, dilate, etc., an opening in a tissue wall at the target site. A side port is defined in the wall of the fluid delivery device adjacent to but upstream of the fluid delivery port. If the fluid delivery port is partially or fully obstructed by contacting tissue, the side port provides a relief valve reducing the pressure of fluid from the fluid delivery port impacting the contacted tissue. The fluid flow path upstream of and adjacent to the side port may be tapered to create a Venturi effect which may cause entrainment of excess fluid at the target site into the fluid delivery device. Such entrained fluid may be recycled out the fluid delivery port.

公开(公告)号：US20240149032A1

公开(公告)日：2024-05-09

申请号：US18550595

申请日：2022-03-15

申请人： Epitomee Medical Ltd.

发明人： Gil Cohen ,  Valery Artamonov ,  Dan Hashimshony

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61M37/00

CPC分类号： A61M31/002 ,  A61K9/0024 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2210/1042

摘要： This disclosure concerns expandable devices, specifically self-deployed devices, for adherence to a tissue, for example intestinal tissue. The disclosure also concerns expandable devices, specifically self-deployed devices for delivery of at least one active agent to, or across, a tissue.

公开(公告)号：US20230355934A1

公开(公告)日：2023-11-09

申请号：US18149649

申请日：2023-01-03

申请人： RenovoRx, Inc.

发明人： Ramtin AGAH ,  Imtiaz L. QURESHI ,  Kamran NAJMABADI ,  Shaun R. BAGAI

IPC分类号： A61M25/10 ,  A61B1/273

CPC分类号： A61M25/1011 ,  A61B1/273 ,  A61M25/1002 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2210/1042 ,  A61M2025/0037

摘要： Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.

公开(公告)号：US11771879B2

公开(公告)日：2023-10-03

申请号：US17153283

申请日：2021-01-20

申请人： Rani Therapeutics, LLC

发明人： Mir Imran

IPC分类号： A61M37/00 ,  A61K9/48 ,  A61M5/00 ,  A61K38/27 ,  A61M25/10 ,  C07K16/18 ,  A61M29/02 ,  C07K16/28 ,  A61M31/00

CPC分类号： A61M37/0015 ,  A61K38/27 ,  A61M5/00 ,  A61M25/10 ,  A61M29/02 ,  C07K16/18 ,  C07K16/2848 ,  A61K9/4808 ,  A61M31/002 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/1042

摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US11771829B2

公开(公告)日：2023-10-03

申请号：US16778152

申请日：2020-01-31

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  Morten Revsgaard Frederiksen ,  Mikkel Oliver Jespersen ,  Brian Mouridsen ,  Jesper Windum ,  Mette Poulsen ,  Brian Jensen ,  Jorrit Jeroen Water ,  Mikkel Wennemoes Hvitfeld Ley ,  Xiaoya Lu ,  Andreas Vegge

IPC分类号： A61M5/20 ,  A61K9/00 ,  A61M5/30

CPC分类号： A61M5/2033 ,  A61K9/0024 ,  A61M5/30 ,  A61M2005/202 ,  A61M2202/0007 ,  A61M2202/30 ,  A61M2210/1042

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

公开(公告)号：US09987437B2

公开(公告)日：2018-06-05

申请号：US15625552

申请日：2017-06-16

申请人： Logan Medical Devices, Inc.

发明人： Tyler S. Markle ,  Dennis I. Robbins ,  Jose Rodriguez ,  David H. Hitt

IPC分类号： A61M5/20 ,  A61M5/315 ,  A61M31/00 ,  A61M5/32

CPC分类号： A61M5/3295 ,  A61M5/20 ,  A61M5/315 ,  A61M5/3157 ,  A61M5/3287 ,  A61M2202/04 ,  A61M2210/1042

摘要： A rectal injection device and a method of operating a rectal injection device. In one embodiment, the device includes: (1) a handle having a trigger associated therewith, (2) an extension tube extending from the handle and terminating in a head, (3) at least two needles coupled to the head and configured to move relative thereto between a retracted position and a deployed position and (4) a pullrod coupling the trigger and the needles and configured to cause the needles to move.

公开(公告)号：US20180008771A1

公开(公告)日：2018-01-11

申请号：US15674421

申请日：2017-08-10

申请人： Rani Therapeutics, LLC

发明人： Mir A. Imran ,  Peter Herrmann ,  Baber Syed ,  Timothy H. Williams ,  Chang Jin Ong ,  Greg Method

IPC分类号： A61M5/155 ,  A61K38/13 ,  A61K38/21 ,  A61K38/26 ,  A61M31/00 ,  A61K38/55 ,  A61K38/29 ,  A61K38/28 ,  A61K38/27 ,  A61K38/30 ,  A61M5/142 ,  A61M37/00 ,  A61K9/48

CPC分类号： A61M5/155 ,  A61K9/4808 ,  A61K38/13 ,  A61K38/21 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K38/30 ,  A61K38/55 ,  A61M5/14244 ,  A61M31/002 ,  A61M37/0069 ,  A61M2205/3331 ,  A61M2210/1042

摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US09844655B2

公开(公告)日：2017-12-19

申请号：US15043052

申请日：2016-02-12

申请人： Rani Therapeutics, LLC

发明人： Mir Imran

IPC分类号： C07K16/18 ,  A61M37/00 ,  A61M25/10 ,  A61M5/00 ,  A61K38/27 ,  A61M29/02 ,  C07K16/28 ,  A61M31/00 ,  A61K9/48

CPC分类号： A61M37/0015 ,  A61K9/4808 ,  A61K38/27 ,  A61M5/00 ,  A61M25/10 ,  A61M29/02 ,  A61M31/002 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/1042 ,  C07K16/18 ,  C07K16/2848

摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US20170303965A1

公开(公告)日：2017-10-26

申请号：US15493956

申请日：2017-04-21

申请人： Massachusetts Institute of Technology ,  Children's Medical Center Corporation

发明人： Daniela Rus ,  Shuhei Miyashita ,  Dana Damian

IPC分类号： A61B17/52 ,  A61M31/00 ,  A61B17/00

CPC分类号： A61B17/52 ,  A61B34/30 ,  A61B34/72 ,  A61B34/73 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2034/303 ,  A61M31/00 ,  A61M2210/1042

摘要： Origami robots, and associated systems, methods of treatment, and methods of manufacture are provided. A system includes an origami robot encapsulated for ingestion by a patient, such as in a biocompatible material that is dissolvable or meltable within the gastrointestinal tract. A method of treatment includes delivering an origami robot in a folded position into a gastrointestinal tract of a patient, causing the origami robot to unfold within the gastrointestinal tract, and directing the origami robot to a site requiring treatment in the gastrointestinal tract.