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公开(公告)号：US20160082178A1
公开(公告)日：2016-03-24
申请号：US14958415
申请日：2015-12-03
申请人： RenovoRx, Inc.
发明人： Ramtin AGAH , Kamran NAJMABADI , Shaun R. BAGAI
CPC分类号： A61M5/007 , A61B6/504 , A61B17/1204 , A61B17/12136 , A61M5/142 , A61M25/007 , A61M25/0097 , A61M25/1002 , A61M25/1011 , A61M2025/0004 , A61M2025/0037 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052 , A61M2210/00 , A61M2210/10 , A61M2230/30
摘要： In some embodiments, a method includes introducing a catheter device into a target artery within a patient where the target artery is near a tumor. The catheter device includes a distal occlusion member and a proximal occlusion member spaced apart from the distal occlusion member. The distal occlusion member is positioned relative to the proximal occlusion member such that an isolated region of the target artery is defined between the distal occlusion member and the proximal occlusion member causing cessation of blood flow in the isolated region. A contrast agent is injected into the target artery and travels to at least one feeder vessel leading to the tumor. A target region in the patient, including the target artery and the tumor, is imaged and a tumor feeder vessel is identified within an image based on the contrast agent visible within the tumor feeder vessel within the image.
摘要翻译： 在一些实施例中，一种方法包括将导管装置引入目标动脉靠近肿瘤的患者内的目标动脉。 导管装置包括远端闭塞构件和与远侧阻塞构件间隔开的近端闭塞构件。 远侧阻塞构件相对于近端阻塞构件定位，使得目标动脉的隔离区域被限定在远端阻塞构件和近端阻塞构件之间，导致隔离区域中的血流停止。 将造影剂注射到目标动脉中，并行进到通向肿瘤的至少一个饲养器皿。 成像患者中包括靶动脉和肿瘤的靶区域，并且基于在图像内的肿瘤供体容器内可见的造影剂，在图像内识别肿瘤供体血管。
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公开(公告)号：US20230355934A1
公开(公告)日：2023-11-09
申请号：US18149649
申请日：2023-01-03
申请人： RenovoRx, Inc.
CPC分类号： A61M25/1011 , A61B1/273 , A61M25/1002 , A61M2025/1015 , A61M2025/1052 , A61M2210/1042 , A61M2025/0037
摘要： Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
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公开(公告)号：US20210268107A1
公开(公告)日：2021-09-02
申请号：US17315220
申请日：2021-05-07
申请人： RenovoRx, Inc.
IPC分类号： A61K39/395 , A61M25/10 , A61B90/00 , A61M31/00 , A61M25/00 , A61N5/10 , A61K39/00 , A61K35/28 , A61K45/06 , A61K31/704 , A61K31/436 , A61K31/513 , A61K31/7068 , A61K31/282 , A61K33/243 , A61K31/4745 , A61K31/404 , A61K31/337 , A61K31/519 , A61K31/502 , A61K51/04 , A61K31/407 , A61K31/573 , A61K38/15 , A61K31/167 , A61K31/166 , A61K31/495 , A61K31/175
摘要： Apparatuses and methods for treating tumors. A method of treatment may include reducing the microvasculature of a region between a tumor and a lumen through or adjacent to the tumor (e.g., by administering radiation therapy targeting the tumor), isolating a segment of a lumen proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment.
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4.发明申请公开(公告)号：US20170056629A1
公开(公告)日：2017-03-02
申请号：US15351922
申请日：2016-11-15
申请人： RenovoRx, Inc.
CPC分类号： A61M25/1011 , A61B1/273 , A61B17/12045 , A61B17/12136 , A61M5/14 , A61M25/007 , A61M25/0097 , A61M25/1002 , A61M2025/0004 , A61M2025/0037 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052 , A61M2210/00 , A61M2210/10 , A61M2210/1042 , A61M2230/30
摘要： Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
摘要翻译： 公开了一种局部治疗癌症的方法，包括提供药物输送导管的步骤; 将导管导向胆管; 并将治疗剂递送到胆管中。 根据该方法的一个方面，药物递送导管是多闭塞球囊导管。 多闭塞球囊导管可以包括至少两个气囊。 多闭塞球囊导管可以可选地包括气囊之间的压力换能器以优化输送技术。
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公开(公告)号：US20210338977A1
公开(公告)日：2021-11-04
申请号：US17367046
申请日：2021-07-02
申请人： RenovoRx, Inc.
发明人： Ramtin AGAH , Kamran NAJMABADI , Shaun BAGAI
摘要： Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.
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公开(公告)号：US20200206481A1
公开(公告)日：2020-07-02
申请号：US16685950
申请日：2019-11-15
申请人： RenovoRx, Inc.
摘要： Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
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公开(公告)号：US20200078555A1
公开(公告)日：2020-03-12
申请号：US16685974
申请日：2019-11-15
申请人： RenovoRx, Inc.
发明人： Ramtin AGAH , Kamran NAJMABADI , Shaun BAGAI
摘要： Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.
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公开(公告)号：US20170157370A1
公开(公告)日：2017-06-08
申请号：US14958428
申请日：2015-12-03
申请人： RenovoRx, Inc.
发明人： Ramtin AGAH , Kamran NAJMABADI , Shaun R. BAGAI , Reza MALEK
CPC分类号： A61M25/1011 , A61B17/1214 , A61M25/0097 , A61M39/24 , A61M2025/0037 , A61M2025/1015 , A61M2025/1045 , A61M2025/105 , A61M2025/1052 , A61M2210/1042 , A61M2210/12
摘要： In some embodiments, an apparatus includes a first catheter movably disposed within a first lumen of a second catheter. The first catheter has a first occlusion member disposed at a distal end portion and the second catheter has a second occlusion member disposed at a distal end portion. A third catheter has a third occlusion member disposed at a distal end portion and is moveably disposable within a second lumen of the second catheter. The second catheter has a side port in fluid communication with the second lumen and the third catheter can be extended out of the second lumen through the side port. The first occlusion member, second occlusion member and third occlusion member can collectively isolate a target region including a portion of a first body lumen (e.g., a main vessel) and a portion of a second body lumen (e.g., a branch of the main vessel).
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公开(公告)号：US20220111184A1
公开(公告)日：2022-04-14
申请号：US17558577
申请日：2021-12-21
申请人： RenovoRx, Inc.
摘要： Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
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公开(公告)号：US20180333563A1
公开(公告)日：2018-11-22
申请号：US15807011
申请日：2017-11-08
申请人： RenovoRx, Inc.
发明人： Ramtin AGAH , Kamran NAJMABADI , Shaun R. BAGAI
IPC分类号： A61M25/10 , A61M31/00 , A61M25/00 , A61N5/10 , A61K31/7068
摘要： Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.
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