公开(公告)号：US20240125025A1

公开(公告)日：2024-04-18

申请号：US18531511

申请日：2023-12-06

申请人： EDWARDS LIFESCIENCES CORPORATION

发明人： James R. Cody, III ,  Ping-Yang Shih ,  Tiffany Diemtrinh Tran

IPC分类号： D05B23/00 ,  A61F2/24 ,  A61K39/015 ,  A61K39/395 ,  C07K14/445 ,  C07K16/20 ,  C07K16/44

CPC分类号： D05B23/00 ,  A61F2/2412 ,  A61F2/2415 ,  A61K39/015 ,  A61K39/39575 ,  C07K14/445 ,  C07K16/205 ,  C07K16/44 ,  A61F2220/0075 ,  D05B19/02

摘要： An automated system that can be used for prosthetic heart valve manufacturing or suturing procedures. The system can include a first automated fixture that includes an articulating arm and a target device holder. The system can also include one or more additional automated fixtures, which can be configured as one or more suturing arms that include another articulating arm and a needle holder. The first automated fixture can be configured to rotate a target device held by the holder to allow the one or more additional automated fixtures to perform operations such as form sutures on the target device without intervention of a human operator. The system can include a display system configured to display status information of a suturing procedure.

公开(公告)号：US20230406912A1

公开(公告)日：2023-12-21

申请号：US18251298

申请日：2021-11-02

申请人： DIATHEVA S.R.L.

发明人： Tomas DI MAMBRO ,  Tania VANZOLINI ,  Mauro MAGNANI

IPC分类号： C07K16/14 ,  A61K39/395 ,  A61K45/06 ,  A61P31/10

CPC分类号： C07K16/14 ,  A61K39/39575 ,  A61K45/06 ,  A61P31/10 ,  C07K2317/24

摘要： The present invention relates to humanised antibody molecules having specificity for β-1,3 glucans and compositions comprising the same. The present invention also relates to the therapeutic uses of the antibody molecules, wherein said use is in the treatment or prophylaxis of fungal infections. It is further claimed a synergistic combination of a) at least one humanised antibody which has specificity for β-1,3 glucans and b) one or more antifungal agents for use in the treatment or prophylaxis of infections of human cells.

公开(公告)号：US20230227542A1

公开(公告)日：2023-07-20

申请号：US18046576

申请日：2022-10-14

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Matthew G. Fury ,  Israel Lowy

IPC分类号： C07K16/18 ,  C07K16/28 ,  A61P35/00 ,  A61K47/68 ,  A61K39/395 ,  A61P35/04 ,  A61K51/10 ,  A61N5/06 ,  C07K16/30

CPC分类号： C07K16/18 ,  C07K16/2818 ,  A61P35/00 ,  C07K16/2878 ,  A61K47/6849 ,  A61K39/39541 ,  A61P35/04 ,  A61K39/39558 ,  A61K51/1045 ,  A61N5/0603 ,  C07K16/28 ,  A61K39/395 ,  A61K39/39575 ,  A61N5/06 ,  C07K16/2803 ,  C07K16/3053 ,  C07K2317/76 ,  A61N2005/1098

摘要： The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

公开(公告)号：US20180153990A1

公开(公告)日：2018-06-07

申请号：US15826297

申请日：2017-11-29

申请人： University of Rochester

发明人： Francis Gigliotti ,  Terry Wright

IPC分类号： A61K39/395 ,  C12N1/16 ,  C07K16/14 ,  A61P11/00

CPC分类号： A61K39/39575 ,  A61K31/635 ,  A61K31/655 ,  A61K39/0002 ,  A61K2039/505 ,  A61K2039/507 ,  A61P11/00 ,  A61P31/00 ,  C07K16/14 ,  C07K2317/33 ,  C12N1/16 ,  A61K2300/00

摘要： The present invention relates to a method of treating Pneumocystis pneumonia infection in a subject. This method involves administering to a subject having a Pneumocystis pneumonia infection one or more antibodies that bind specifically to a Pneumocystis cross-reactive antigen 1 (PCA1) protein under conditions effective to treat the Pneumocystis infection in the subject. Another aspect of the present invention relates to a method of treating a subject at risk for Pneumocystis pneumonia infection. A further aspect of the present invention relates to an isolated protein or polypeptide comprising the amino acid sequence of SEQ ID NO:1. Another aspect of the present invention relates to a pharmaceutical composition comprising the isolated protein or polypeptide of the present invention and a pharmaceutically acceptable carrier.

公开(公告)号：US09982040B2

公开(公告)日：2018-05-29

申请号：US15088801

申请日：2016-04-01

申请人： Her Majesty the Queen in Right of Canada, as represented by the Minister of National Defence

发明人： Wei-Gang Hu ,  Laurel M. Negrych ,  Damon Chau ,  Junfei Yin ,  Scott J. Jager ,  John W. Cherwonogrodzky

IPC分类号： C07K16/00 ,  C07K16/16 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/16 ,  A61K39/39575 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof as well as their use in therapy or prophylaxis.

公开(公告)号：US20160046699A1

公开(公告)日：2016-02-18

申请号：US14783237

申请日：2014-04-10

申请人： KING'S COLLEGE LONDON ,  LEIBNIZ INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V.

发明人： Julian NAGLIK ,  David MOYES ,  Shirley TANG ,  Bernhard HUBE ,  Duncan WILSON ,  Sarah HOFS ,  Jonathan RICHARDSON

IPC分类号： C07K16/14 ,  G01N33/68 ,  A61K39/00 ,  C07K14/40 ,  A61K39/395

CPC分类号： C07K16/14 ,  A61K39/0002 ,  A61K39/39 ,  A61K39/39575 ,  A61K2039/52 ,  C07K14/40 ,  G01N33/6845 ,  G01N2500/04 ,  G01N2500/20

摘要： The invention provides a peptide obtainable from C. albicans as well as variants and fragments thereof, and labelled forms of these. The peptide is immunogenic and specific binding partners for the peptide and labelled forms of these specific binding partners form a further aspect of the invention. The peptide is a fragment of the ECE1 protein and has been found to be both immunogenic and act as a pore-forming toxin. A range of therapeutic and diagnostic applications for the peptide and the specific binding partners for it form further aspects of the invention. In addition, the peptide may be used in screens for identifying compounds having useful anti-fungal activity.

摘要翻译： 本发明提供了可从白色念珠菌获得的肽及其变体和片段，以及这些的标记形式。 肽是针对肽的免疫原性和特异性结合配偶体，并且这些特异性结合伴侣的标记形式形成本发明的另一方面。 肽是ECE1蛋白的片段，并且已被发现既是免疫原性的并且起着孔隙形成毒素的作用。 用于肽和特异性结合配偶体的一系列治疗和诊断应用形成本发明的其它方面。 此外，肽可以用于筛选用于鉴定具有有用的抗真菌活性的化合物。

公开(公告)号：US20150329624A1

公开(公告)日：2015-11-19

申请号：US14727152

申请日：2015-06-01

申请人： CHARITE - UNIVERSITATSMEDIZIN BERLIN

发明人： Karl SKRINER

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  A61K39/39575 ,  C07K16/16 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/76

摘要： The present invention relates to an IgY composition characterized in that said IgY composition contains IgY antibodies, fragments, and/or Fab fragments thereof that specifically bind to a peptide with the amino acid sequence of SEQ ID NO: 1 and to the use of this IgY composition in the therapy of celiac disease, rheumatism, and/or wheat allergy.

摘要翻译： 本发明涉及IgY组合物，其特征在于所述IgY组合物含有与SEQ ID NO：1的氨基酸序列特异性结合肽的IgY抗体，片段和/或Fab片段，以及该IgY的使用 治疗乳糜泻，风湿病和/或小麦过敏的组合物。

公开(公告)号：US20140302045A1

公开(公告)日：2014-10-09

申请号：US14225882

申请日：2014-03-26

申请人： CHARITE - UNIVERSITATSMEDIZIN BERLIN

发明人： Karl SKRINER

IPC分类号： C07K16/16 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/39575 ,  C07K16/16 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/76

摘要： The present invention relates to an IgY composition characterized in that said IgY composition contains IgY antibodies, fragments, and/or Fab fragments thereof that specifically bind to a peptide with the amino acid sequence of SEQ ID NO: 1 and to the use of this IgY composition in the therapy of celiac disease, rheumatism, and/or wheat allergy.

摘要翻译： 本发明涉及IgY组合物，其特征在于所述IgY组合物含有与SEQ ID NO：1的氨基酸序列特异性结合肽的IgY抗体，片段和/或Fab片段，以及该IgY的使用 治疗乳糜泻，风湿病和/或小麦过敏的组合物。

公开(公告)号：US20140044734A1

公开(公告)日：2014-02-13

申请号：US14000850

申请日：2012-02-21

申请人： Ronit Sverdlov ,  Veerle Bieghs ,  Patrick Johannes Jacobus van Gorp

发明人： Ronit Sverdlov ,  Veerle Bieghs ,  Patrick Johannes Jacobus van Gorp

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/395

CPC分类号： A61K39/39575 ,  A61K39/0005 ,  A61K39/0012 ,  A61K39/0013 ,  A61K39/092 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/521 ,  A61K2039/55566 ,  C07K16/1275 ,  C07K16/18

摘要： The invention is in the field of prevention and medical treatment of liver diseases, in particular non-alcoholic steatohepatitis (NASH). The invention provides means and methods for the treatment of hepatic inflammation, fibrosis and more in particular NASH. More in particular, the invention provides a composition capable of raising anti-oxLDL antibodies in vivo for use in the treatment of liver inflammation or fibrosis.

摘要翻译： 本发明涉及肝病，特别是非酒精性脂肪性肝炎（NASH）的预防和治疗领域。 本发明提供治疗肝炎，纤维化，尤其是NASH的方法和方法。 更具体地，本发明提供能够在体内提高抗oxLDL抗体用于治疗肝脏炎症或纤维化的组合物。

公开(公告)号：US20100285029A1

公开(公告)日：2010-11-11

申请号：US11984177

申请日：2007-11-14

申请人： James P. Burnie

发明人： James P. Burnie

IPC分类号： A61K39/395 ,  C07K16/14 ,  A61P31/10 ,  G01N33/53

CPC分类号： C07K16/14 ,  A61K31/10 ,  A61K31/407 ,  A61K31/70 ,  A61K39/39575 ,  A61K45/06 ,  A61K47/6835 ,  A61K2039/505 ,  A61K2300/00

摘要： The present invention relates to novel compositions and preparations that are effective antifungal agents, and a novel antibody which can be incorporated into the compositions and preparations.

摘要翻译： 本发明涉及作为有效抗真菌剂的新型组合物和制剂，以及可并入组合物和制剂中的新型抗体。