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    Method for production of dry yeast containing S-adenosyl-L-methionine and having excellent storage stability, product produced by the method, and molded composition of the dry yeast
    2.
    发明授权
    Method for production of dry yeast containing S-adenosyl-L-methionine and having excellent storage stability, product produced by the method, and molded composition of the dry yeast 有权
    生产含有S-腺苷-L-甲硫氨酸的干酵母并具有优异的储存稳定性的方法，通过该方法生产的产品和干酵母的模塑组合物

    公开(公告)号：US09200250B2

    公开(公告)日：2015-12-01

    申请号：US12524050

    申请日：2008-01-23

    Applicant: Kentarou Takano ,  Shinyo Gayama

    Inventor： Kentarou Takano ,  Shinyo Gayama

    IPC: C12N1/16 ,  C12N1/18 ,  A23L1/30 ,  C12N1/04

    CPC classification number: C12N1/18 ,  A23L33/13 ,  A23L33/14 ,  A23V2002/00 ,  C12N1/04 ,  A23V2250/218 ,  A23V2250/312

    Abstract: The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry yeast obtained by the production method, and a composition formed by molding the dry yeast. According to the present invention, a dry yeast containing S-adenosyl-L-methionine, which is useful as an aqueous physiologically active substance, in a high concentration excellent in storage stability and a composition obtained by molding the dry yeast can be produced conveniently and economically and can be brought into the market.

    Abstract translation: 本发明涉及使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，该方法包括：将环糊精化合物加入到由 酵母真菌培养液; 然后干燥浓缩物，通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的组合物。 根据本发明，可以方便地制造含有S-作为生理活性物质的S-腺苷-L-甲硫氨酸的干酵母，其贮藏稳定性优异的高浓度和通过成型干酵母获得的组合物， 在经济上可以进入市场。

    METHOD FOR PRODUCTION OF DRY YEAST CONTAINING S-ADENOSYL-L-METHIONINE AND HAVING EXCELLENT STORAGE STABILITY, PRODUCT PRODUCED BY THE METHOD, AND MOLDED COMPOSITION OF THE DRY YEAST
    4.
    发明申请
    METHOD FOR PRODUCTION OF DRY YEAST CONTAINING S-ADENOSYL-L-METHIONINE AND HAVING EXCELLENT STORAGE STABILITY, PRODUCT PRODUCED BY THE METHOD, AND MOLDED COMPOSITION OF THE DRY YEAST 有权
    生产含有S-腺苷-L-甲硫氨酸的干燥并具有优良储存稳定性的方法，该方法生产的产品和干燥的YEAST的成型组合物

    公开(公告)号：US20100075403A1

    公开(公告)日：2010-03-25

    申请号：US12524050

    申请日：2008-01-23

    Applicant: Kentarou Takano ,  Shinyo Gayama

    Inventor： Kentarou Takano ,  Shinyo Gayama

    IPC: C12N1/16

    CPC classification number: C12N1/18 ,  A23L33/13 ,  A23L33/14 ,  A23V2002/00 ,  C12N1/04 ,  A23V2250/218 ,  A23V2250/312

    Abstract: The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry yeast obtained by the production method, and a composition formed by molding the dry yeast. According to the present invention, a dry yeast containing S-adenosyl-L-methionine, which is useful as an aqueous physiologically active substance, in a high concentration excellent in storage stability and a composition obtained by molding the dry yeast can be produced conveniently and economically and can be brought into the market.

    Abstract translation: 本发明涉及使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，该方法包括：将环糊精化合物加入到由 酵母真菌培养液; 然后干燥浓缩物，通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的组合物。 根据本发明，可以方便地制造含有S-作为生理活性物质的S-腺苷-L-甲硫氨酸的干酵母，其贮藏稳定性优异的高浓度和通过成型干酵母获得的组合物， 在经济上可以进入市场。

    S-ADENOSYLMETHIONINE FORMULATIONS WITH ENHANCED BIOAVAILABILITY
    8.
    发明申请
    S-ADENOSYLMETHIONINE FORMULATIONS WITH ENHANCED BIOAVAILABILITY 审中-公开
    S-ADENOSYLMETHIONINE配方与增强的生物利用度

    公开(公告)号：US20130142847A1

    公开(公告)日：2013-06-06

    申请号：US13811772

    申请日：2011-07-27

    Applicant: I. David MacDonald ,  Nancy Harrison ,  Aniko Takacs-Cox ,  Admir Purac ,  Almira Blazek-Welsh

    Inventor： I. David MacDonald ,  Nancy Harrison ,  Aniko Takacs-Cox ,  Admir Purac ,  Almira Blazek-Welsh

    IPC: A61K31/7076

    CPC classification number: A61K31/7076 ,  A23V2002/00 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2846 ,  A61K47/12 ,  A61K47/14 ,  A61K47/186 ,  A61K47/40 ,  A23V2250/312

    Abstract: Provided herein are compositions and methods to enhance the absorption of S-adenosylmethionine (SAMe) and methods of treating various disorders or diseases using non-parenteral SAMe formulations with enhanced-absorption and improved bioavailability. In certain embodiments, the enhanced bioavailability formulations provided herein may be used to treat a variety of diseases or disorders, such as for example, psychiatric disorders including, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, depressive disorders (e.g. major clinical depression) and dysthymia; as well as treating liver disorders, cancer, autoimmune disorders, inflammatory disorders, joint disorders, gastrointestinal disorders and cardiovascular disease.

    Abstract translation: 本文提供了增强S-腺苷甲硫氨酸（SAMe）吸收的组合物和方法以及使用具有增强吸收和改善的生物利用度的非肠胃外SAMe制剂治疗各种疾病或疾病的方法。 在某些实施方案中，本文提供的增强的生物利用度制剂可用于治疗各种疾病或病症，例如精神疾病，包括广泛性焦虑症，强迫症，创伤后应激障碍，恐慌症，抑郁症（ 例如主要临床抑郁症）和精神抑郁; 以及治疗肝脏疾病，癌症，自身免疫性疾病，炎性疾病，关节疾病，胃肠道疾病和心血管疾病。

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