公开(公告)号：US20240382497A1

公开(公告)日：2024-11-21

申请号：US18785986

申请日：2024-07-26

Applicant: SCENT SCIENCE INTERNATIONAL INC.

Inventor： Ko KOBAYAKAWA ,  Reiko Kobayakawa

IPC: A61K31/54 ,  A01N1/02 ,  A61K9/00 ,  A61K31/26 ,  A61K31/426 ,  A61P9/10

Abstract: A prophylactic or therapeutic agent for hypoxic injury, ischemia-reperfusion injury or inflammation, an agent for protecting cells for transplantation, and an agent for preserving organism are disclosed. A prophylactic or therapeutic agent for hypoxic injury, ischemia-reperfusion injury or inflammation, an agent for protecting cells for transplantation, or an agent for preserving organism, containing, as an active ingredient, at least one kind selected from a heterocyclic compound represented by the formula (I) wherein each symbol is as described in the DESCRIPTION, or a salt thereof; an isothiocyanate compound represented by the formula S═C═N—R5 (II) wherein the symbol is as described in the DESCRIPTION; and a TRPA1 agonist.

公开(公告)号：US12070482B2

公开(公告)日：2024-08-27

申请号：US18241567

申请日：2023-09-01

Applicant: Bonafide Health, LLC

Inventor： James R. Komorowski ,  Sarah Sylla

IPC: A61K36/00 ,  A61K31/26 ,  A61K36/82 ,  A61K36/9066 ,  A61P15/12

CPC classification number: A61K36/9066 ,  A61K31/26 ,  A61K36/82 ,  A61P15/12

Abstract: Disclosed herein are compositions for treating, ameliorating, preventing, or reducing the symptoms associated with menopause and/or hot flashes. The compositions disclosed herein comprise a curcumin composition, a green tea extract composition, and a phycocyanin composition that act as neurokinin 3 receptor antagonists. Also described herein are methods utilizing the aforementioned compositions.

公开(公告)号：US12064471B2

公开(公告)日：2024-08-20

申请号：US17178664

申请日：2021-02-18

Applicant: NUTRAMAX LABORATORIES, INC.

Inventor： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson

IPC: A23L33/105 ,  A61K9/00 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/00 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K38/47 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06

CPC classification number: A61K38/47 ,  A23L33/105 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A23V2002/00 ,  A61K36/31 ,  A61K2300/00 ,  A61K33/06 ,  A61K2300/00 ,  A61K31/7028 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00 ,  A61K31/375 ,  A61K2300/00 ,  A61K31/26 ,  A61K2300/00 ,  A61K36/28 ,  A61K2300/00 ,  A61K36/06 ,  A61K2300/00 ,  A61K36/07 ,  A61K2300/00

Abstract: The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, a cofactor of the enzyme, and a glucan. The present disclosure also relates to the synergistic combination of sulforaphane or a derivative thereof and a glucan. The present disclosure also relates to the synergistic combination of a broccoli extract or powder and a glucan. The glucan may be a β-glucan. The glucan may be provided in a mushroom extract or powder selected from one or more of a maitake, a shiitake, or a reishi mushroom. Compositions and methods relating to these combinations are described.

公开(公告)号：US11969436B2

公开(公告)日：2024-04-30

申请号：US16768180

申请日：2018-11-29

Applicant: Kao Corporation

Inventor： Rie Ninomiya ,  Takafumi Nishijima ,  Noriko Sato

IPC: A61K31/7028 ,  A61K31/26 ,  A61K36/31 ,  A61P17/04 ,  A61Q19/00 ,  C12Q1/44 ,  G01N33/50

CPC classification number: A61K31/7028 ,  A61K31/26 ,  A61K36/31 ,  A61P17/04 ,  C12Q1/44 ,  G01N33/5023

Abstract: To provide a method for evaluating or selecting an agent for reducing sensory irritation, which reduces sensory irritation caused by parabens, and an agent for reducing sensory irritation, which reduces sensory irritation caused by parabens. A method for evaluating or selecting an agent for reducing sensory irritation caused by parabens, comprising the following steps (1) to (3): (1) a step of contacting cells capable of expressing CES1 with a test substance; (2) a step of measuring expression of CES1 in the cells; (3) a step of evaluating a test substance which promotes expression of CES1 as an agent for reducing sensory irritation caused by parabens based on the results measured in (2).

公开(公告)号：US20240108596A1

公开(公告)日：2024-04-04

申请号：US18266632

申请日：2021-12-13

Applicant: Filip LARSEN

Inventor： Filip LARSEN

IPC: A61K31/26 ,  A61K31/7028 ,  A61K36/31 ,  A61K38/47 ,  A61P3/02

CPC classification number: A61K31/26 ,  A61K31/7028 ,  A61K36/31 ,  A61K38/47 ,  A61P3/02 ,  C12Y302/01147

Abstract: The present invention relates to compositions, uses and methods for improving physical exercise performance, and/or improving adaptation to physical exercise, and/or modulating the concentration of lactate and/or glucose in the blood of a human subject.

公开(公告)号：US11857594B2

公开(公告)日：2024-01-02

申请号：US17968788

申请日：2022-10-18

Applicant: Bonafide Health, LLC

Inventor： James R. Komorowski ,  Sarah Sylla

IPC: A61K36/00 ,  A61K36/9066 ,  A61P15/12 ,  A61K36/82 ,  A61K31/26

CPC classification number: A61K36/9066 ,  A61K31/26 ,  A61K36/82 ,  A61P15/12

Abstract: Disclosed herein are compositions for treating, ameliorating, preventing, or reducing the symptoms associated with menopause and/or hot flashes. The compositions disclosed herein comprise a curcumin composition, a green tea extract composition, and a phycocyanin composition that act as neurokinin 3 receptor antagonists. Also described herein are methods utilizing the aforementioned compositions.

公开(公告)号：US20230364049A1

公开(公告)日：2023-11-16

申请号：US18246585

申请日：2021-09-24

Applicant: VIB VZW ,  KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D

Inventor： Massimiliano MAZZONE

IPC: A61K31/26 ,  A61K39/395 ,  A61K39/00 ,  A61P35/00

CPC classification number: A61K31/26 ,  A61K39/3955 ,  A61K39/4646 ,  A61K39/4614 ,  A61P35/00

Abstract: The invention is situated in the field of cancer treatment. In particular it relates to treatments comprising combining an inhibitor of the pyrimidinergic receptor P2Y6 and an immune checkpoint inhibitor. Further in particular, the treatment is of benefit for cancers poorly responding to immune checkpoint inhibitor therapy.

公开(公告)号：US20230310330A1

公开(公告)日：2023-10-05

申请号：US18131280

申请日：2023-04-05

Applicant: BIOVENTURES, LLC ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

Inventor： Zeeshan Habeeb ,  Ruud Dings

IPC: A61K9/50 ,  A61K31/26 ,  A61P35/00

CPC classification number: A61K9/5052 ,  A61K31/26 ,  A61P35/00

Abstract: Disclosed herein are biocompatible peptidic oligomers and methods of using the same where the biocompatible peptidic oligomer encapsulates an agent and the biocompatible peptidic oligomer comprises a linear chain formed from a multiplicity of independently selected nonproteogenic amino acids joined by amide bonds and the nonproteogenic amino acids comprise two or more optionally substituted methylene groups interposed between a terminal amino and a terminal carboxylic acid or ester group.

公开(公告)号：US11654129B2

公开(公告)日：2023-05-23

申请号：US17141300

申请日：2021-01-05

Applicant: THE WILLIAM M YARBROUGH FOUNDATION

Inventor： Michael E. Silver

IPC: C07C331/20 ,  A61K31/26 ,  A61P17/00 ,  A61K9/00 ,  A61K47/34 ,  A61K9/06 ,  A61K45/06 ,  A61K31/145 ,  A61K31/198

CPC classification number: A61K31/26 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/145 ,  A61K31/198 ,  A61K45/06 ,  A61K47/34 ,  C07C331/20 ,  A61K31/198 ,  A61K2300/00 ,  A61K31/145 ,  A61K2300/00

Abstract: An isothiocyanate functional surfactant, wherein the protonated form of said surfactant is represented by the following chemical structure:




wherein X includes an integer ranging from approximately 1 to approximately 25, and wherein Y includes an integer ranging from approximately 6 to approximately 25.

公开(公告)号：US20230149420A1

公开(公告)日：2023-05-18

申请号：US17906962

申请日：2021-03-25

Applicant: SCENT SCIENCE INTERNATIONAL INC.

Inventor： Ko KOBAYAKAWA ,  Reiko KOBAYAKAWA

IPC: A61K31/55 ,  A61K31/426 ,  A61K31/381 ,  A61K31/40 ,  A61K31/428 ,  A61K31/4406 ,  A61K31/54 ,  A61K31/4409 ,  A61K31/5415 ,  A61K31/497 ,  A61K31/47 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/26 ,  A61K31/44 ,  A61K31/341 ,  A61K31/343 ,  A61P29/00 ,  A61P37/04

CPC classification number: A61K31/55 ,  A61K31/426 ,  A61K31/381 ,  A61K31/40 ,  A61K31/428 ,  A61K31/4406 ,  A61K31/54 ,  A61K31/4409 ,  A61K31/5415 ,  A61K31/497 ,  A61K31/47 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/26 ,  A61K31/44 ,  A61K31/341 ,  A61K31/343 ,  A61P29/00 ,  A61P37/04

Abstract: The present invention provides an anti-inflammatory type immune-enhancing agent that simultaneously induces an anti-inflammatory action and an immune-enhancing action. An anti-inflammatory type immune-enhancing agent containing at least one kind selected from a heterocyclic compound represented by the formula (I)




wherein each symbol is as described in the DESCRIPTION, or a salt thereof, and an isothiocyanate compound represented by the formula S═C═N—R5 (II) wherein the symbol is as described in the DESCRIPTION, as an active ingredient.