公开(公告)号：US20240325505A1

公开(公告)日：2024-10-03

申请号：US18288797

申请日：2022-09-08

申请人： Beijing University of Chemical Technology

发明人： Qipeng YUAN ,  Li CHENG ,  Pengtao LIU

IPC分类号： A61K38/47 ,  A61K31/7028 ,  A61P17/00 ,  A61P17/14

CPC分类号： A61K38/47 ,  A61K31/7028 ,  A61P17/00 ,  A61P17/14 ,  C12Y302/01147

摘要： The present disclosure relates to a pharmaceutical composition for improving and treating leukotrichia and/or alopecia and a preparation method thereof. In the present disclosure, the pharmaceutical composition includes glucoraphanin and myrosinase as active ingredients, where the glucoraphanin has a content of 0.1% to 50% and the myrosinase has a total enzyme activity of 0.1 mU to 10 U based on a total weight of the pharmaceutical composition. The pharmaceutical composition shows safety, rapidity, effective improvement and treatment of leukotrichia and/or alopecia, and wide application range for subjects.

公开(公告)号：US20240261341A1

公开(公告)日：2024-08-08

申请号：US18432028

申请日：2024-02-04

申请人： Matthew Wook Chang ,  Chun Loong Ho

发明人： Matthew Wook Chang ,  Chun Loong Ho

IPC分类号： A61K35/741 ,  A61P35/00 ,  C12N9/24 ,  C12N15/52

CPC分类号： A61K35/741 ,  A61P35/00 ,  C12N9/2402 ,  C12N15/52 ,  C12Y302/01147

摘要： The claimed invention provides therapeutic as well as protective measures against colorectal cancer by utilizing genetically modified gut bacteria (101) in conjunction with an optimized diet high in cruciferous vegetable intake. According to the claimed system and method, engineered gut bacteria maximize the therapeutic value of the cruciferous vegetable diet to eradicate, offset or prophylactically prevent the onset of colorectal cancer. In the claimed invention gut bacteria Escherichia coli bind specifically to the heparan sulphate proteoglycan on colorectal cancer cells to secrete the enzyme myrosinase to transform host-ingested glucosinolates which are natural components of cruciferous vegetables to sulphoraphane, an organic small molecule with known anti-cancer activity.

公开(公告)号：US20150118305A1

公开(公告)日：2015-04-30

申请号：US14586698

申请日：2014-12-30

申请人： Nutramax Laboratories, Inc.

发明人： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson

IPC分类号： A61K38/47 ,  A61K36/31 ,  A61K31/19 ,  A61K9/28 ,  A61K31/7028 ,  A61K31/375

CPC分类号： A61K38/47 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A61K2300/00

摘要： The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and ursolic acid, a salt, ester, amide, or derivative thereof. The invention also relates to the combination of a sulforaphane or a derivative thereof and ursolic acid, a salt, ester, amide, or derivative thereof. The invention also relates to the combination of a broccoli extract or powder and ursolic acid, a salt, ester, amide, or derivative thereof. The invention provides compositions and methods relating to these combinations.

摘要翻译： 本发明涉及萝卜硫素前体，能够将萝卜硫素前体转化为萝卜硫素的酶，酶增效剂和熊果酸，其盐，酯，酰胺或其衍生物的组合。 本发明还涉及萝卜硫素或其衍生物与熊果酸，其盐，酯，酰胺或其衍生物的组合。 本发明还涉及西兰花提取物或粉末与熊果酸，其盐，酯，酰胺或其衍生物的组合。 本发明提供了与这些组合有关的组合物和方法。

公开(公告)号：US20150118304A1

公开(公告)日：2015-04-30

申请号：US14586711

申请日：2014-12-30

申请人： Nutramax Laboratories, Inc.

发明人： Brian CORNBLATT ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson ,  Ronald Kettenacker

IPC分类号： A61K31/26 ,  A61K9/00 ,  A61K33/06 ,  A61K45/06 ,  A61K36/31 ,  A61K31/194 ,  A61K47/42 ,  A61K9/28

CPC分类号： A61K38/47 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A61K2300/00

摘要： The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and magnesium or a salt or complex thereof. The invention also relates to the combination of a sulforaphane or a derivative thereof and magnesium or a salt or complex thereof. The invention also relates to the combination of a broccoli extract or powder and magnesium or a salt or complex thereof. The invention provides compositions and methods relating to these combinations.

公开(公告)号：US20130347145A1

公开(公告)日：2013-12-26

申请号：US14003278

申请日：2012-02-24

申请人： Yoichi Ogawa ,  Yasuhiro Kondo ,  Ikuko Nishimura ,  Makoto Shirakawa ,  Haruko Ueda ,  Tomoo Shimada

发明人： Yoichi Ogawa ,  Yasuhiro Kondo ,  Ikuko Nishimura ,  Makoto Shirakawa ,  Haruko Ueda ,  Tomoo Shimada

IPC分类号： C12N9/24

CPC分类号： C12N9/2405 ,  C07K2319/01 ,  C12N9/2408 ,  C12N15/8221 ,  C12Y302/01147

摘要： According to the present invention, a method for stably accumulating a target protein in plant cells or a plant body, and a transgenic plant in which protein has accumulated, are provided. The method of the present invention is a method for accumulating protein in plant cells, comprising accumulating a target protein or a protein deficient in an N-terminal region of the target protein in vacuoles of myrosin cells present in a multiple mutant, in which myrosin cells deficient in intravacuolar protein are also present in a plant body at locations other than around vascular bundles, by expressing a gene that encodes a target protein having an intracellular membrane system localization signal on the N-terminal and a vacuole localization signal on the C-terminal in the multiple mutant.

摘要翻译： 根据本发明，提供了用于在植物细胞或植物体中稳定地积聚靶蛋白的方法和其中积累了蛋白质的转基因植物。 本发明的方法是在植物细胞中积聚蛋白质的方法，其特征在于：在存在于多突变体中的黑素瘤细胞的空泡中积聚靶蛋白的N末端区域的靶蛋白或缺失蛋白质的蛋白质， 通过在N末端表达编码具有细胞内膜系统定位信号的靶蛋白的基因和C末端的液泡定位信号，也存在于血管内蛋白质不足的植物体内， 在多重突变体中。

公开(公告)号：US12064471B2

公开(公告)日：2024-08-20

申请号：US17178664

申请日：2021-02-18

申请人： NUTRAMAX LABORATORIES, INC.

发明人： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson

IPC分类号： A23L33/105 ,  A61K9/00 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/00 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K38/47 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06

CPC分类号： A61K38/47 ,  A23L33/105 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A23V2002/00 ,  A61K36/31 ,  A61K2300/00 ,  A61K33/06 ,  A61K2300/00 ,  A61K31/7028 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00 ,  A61K31/375 ,  A61K2300/00 ,  A61K31/26 ,  A61K2300/00 ,  A61K36/28 ,  A61K2300/00 ,  A61K36/06 ,  A61K2300/00 ,  A61K36/07 ,  A61K2300/00

摘要： The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, a cofactor of the enzyme, and a glucan. The present disclosure also relates to the synergistic combination of sulforaphane or a derivative thereof and a glucan. The present disclosure also relates to the synergistic combination of a broccoli extract or powder and a glucan. The glucan may be a β-glucan. The glucan may be provided in a mushroom extract or powder selected from one or more of a maitake, a shiitake, or a reishi mushroom. Compositions and methods relating to these combinations are described.

公开(公告)号：US20240108596A1

公开(公告)日：2024-04-04

申请号：US18266632

申请日：2021-12-13

申请人： Filip LARSEN

发明人： Filip LARSEN

IPC分类号： A61K31/26 ,  A61K31/7028 ,  A61K36/31 ,  A61K38/47 ,  A61P3/02

CPC分类号： A61K31/26 ,  A61K31/7028 ,  A61K36/31 ,  A61K38/47 ,  A61P3/02 ,  C12Y302/01147

摘要： The present invention relates to compositions, uses and methods for improving physical exercise performance, and/or improving adaptation to physical exercise, and/or modulating the concentration of lactate and/or glucose in the blood of a human subject.

公开(公告)号：US20190209625A1

公开(公告)日：2019-07-11

申请号：US16240648

申请日：2019-01-04

申请人： Matthew Wook Chang ,  Chun Loong Ho

发明人： Matthew Wook Chang ,  Chun Loong Ho

IPC分类号： A61K35/741 ,  A61P35/00 ,  C12N9/24 ,  C12N15/52

CPC分类号： A61K35/741 ,  A61P35/00 ,  C12N9/2402 ,  C12N15/52 ,  C12Y302/01147

摘要： The claimed invention provides therapeutic as well as protective measures against colorectal cancer by utilizing genetically modified gut bacteria (101) in conjunction with an optimized diet high in cruciferous vegetable intake. According to the claimed system and method, engineered gut bacteria maximize the therapeutic value of the cruciferous vegetable diet to eradicate, offset or prophylactically prevent the onset of colorectal cancer. In the claimed invention gut bacteria Escherichia coli bind specifically to the heparan sulphate proteoglycan on colorectal cancer cells to secrete the enzyme myrosinase to transform host-ingested glucosinolates which are natural components of cruciferous vegetables to sulphoraphane, an organic small molecule with known anti-cancer activity.

公开(公告)号：US20170049676A1

公开(公告)日：2017-02-23

申请号：US15306891

申请日：2015-04-21

申请人： Conopco, Inc., d/b/a UNILEVER

发明人： Mark John BERRY ,  Mark lan FOWLER ,  Gail JENKINS ,  Jennifer Elizabeth POPLE ,  Sally Pamela REDFERN

IPC分类号： A61K8/60 ,  A61K8/97 ,  A61K8/66 ,  A61Q17/04

CPC分类号： A61K8/602 ,  A61K8/66 ,  A61K8/97 ,  A61K38/47 ,  A61K2800/782 ,  A61K2800/882 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/007 ,  C12Y302/01147

摘要： The inventors have observed that aqueous mustard seed extract appears to be cytotoxic to fibroblast cells. The cytotoxicity of the aqueous mustard seed extract appears to abate when the extract is heat treated at 120° C. for 15 minutes. The heat treated aqueous mustard seed extract when combined with exogenous myrosinase is not cytotoxic but can induce a modest increase in HO-1 content in cultured fibroblasts and thus would be expected to be useful in a topical composition for treating/preventing itchy skin, particularly the scalp. This invention thus relates to the provision of a topical composition for treating/preventing itchy skin, particularly the scalp.

摘要翻译： 发明人已经观察到，芥子籽提取物似乎对成纤维细胞具有细胞毒性。 当提取物在120℃热处理15分钟时，芥子籽提取物的细胞毒性似乎降低了。 当与外源性黑芥子酶组合时，热处理的芥菜籽提取物不是细胞毒性的，但可以诱导培养的成纤维细胞中HO-1含量的适度增加，因此预期可用于治疗/预防瘙痒皮肤的局部组合物，特别是 头皮。 因此，本发明涉及提供用于治疗/预防瘙痒皮肤，特别是头皮的局部组合物。

公开(公告)号：US20160354448A1

公开(公告)日：2016-12-08

申请号：US15244374

申请日：2016-08-23

申请人： NUTRAMAX LABORATORIES, INC.

发明人： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson

IPC分类号： A61K38/47 ,  A61K31/375 ,  A61K31/26 ,  A61K36/31 ,  A61K36/07 ,  A61K31/7028 ,  A61K31/716

CPC分类号： A61K38/47 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A61K2300/00

摘要： The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, a cofactor of the enzyme, and a glucan. The present disclosure also relates to the synergistic combination of sulforaphane or a derivative thereof and a glucan. The present disclosure also relates to the synergistic combination of a broccoli extract or powder and a glucan. The glucan may be a β-glucan. The glucan may be provided in a mushroom extract or powder selected from one or more of a maitake, a shiitake, or a reishi mushroom. Compositions and methods relating to these combinations are described.

摘要翻译： 本公开内容涉及萝卜硫素前体，能够转化萝卜硫素前体与萝卜硫素的酶，酶的辅因子和葡聚糖的协同组合。 本公开还涉及萝卜硫素或其衍生物和葡聚糖的协同组合。 本公开还涉及青花菜提取物或粉末与葡聚糖的协同组合。 葡聚糖可以是β-葡聚糖。 葡聚糖可以提供在蘑菇提取物或选自以下的一种或多种中的一种或多种粉末：香菇或香菇。 描述与这些组合有关的组合物和方法。