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    S-ADENOSYLMETHIONINE FORMULATIONS WITH ENHANCED BIOAVAILABILITY
    1.
    发明申请
    S-ADENOSYLMETHIONINE FORMULATIONS WITH ENHANCED BIOAVAILABILITY 审中-公开
    S-ADENOSYLMETHIONINE配方与增强的生物利用度

    公开(公告)号：US20130142847A1

    公开(公告)日：2013-06-06

    申请号：US13811772

    申请日：2011-07-27

    Applicant: I. David MacDonald ,  Nancy Harrison ,  Aniko Takacs-Cox ,  Admir Purac ,  Almira Blazek-Welsh

    Inventor： I. David MacDonald ,  Nancy Harrison ,  Aniko Takacs-Cox ,  Admir Purac ,  Almira Blazek-Welsh

    IPC: A61K31/7076

    CPC classification number: A61K31/7076 ,  A23V2002/00 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2846 ,  A61K47/12 ,  A61K47/14 ,  A61K47/186 ,  A61K47/40 ,  A23V2250/312

    Abstract: Provided herein are compositions and methods to enhance the absorption of S-adenosylmethionine (SAMe) and methods of treating various disorders or diseases using non-parenteral SAMe formulations with enhanced-absorption and improved bioavailability. In certain embodiments, the enhanced bioavailability formulations provided herein may be used to treat a variety of diseases or disorders, such as for example, psychiatric disorders including, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, depressive disorders (e.g. major clinical depression) and dysthymia; as well as treating liver disorders, cancer, autoimmune disorders, inflammatory disorders, joint disorders, gastrointestinal disorders and cardiovascular disease.

    Abstract translation: 本文提供了增强S-腺苷甲硫氨酸（SAMe）吸收的组合物和方法以及使用具有增强吸收和改善的生物利用度的非肠胃外SAMe制剂治疗各种疾病或疾病的方法。 在某些实施方案中，本文提供的增强的生物利用度制剂可用于治疗各种疾病或病症，例如精神疾病，包括广泛性焦虑症，强迫症，创伤后应激障碍，恐慌症，抑郁症（ 例如主要临床抑郁症）和精神抑郁; 以及治疗肝脏疾病，癌症，自身免疫性疾病，炎性疾病，关节疾病，胃肠道疾病和心血管疾病。

    Pharmacokinetics of S-adenosylmethionine formulations
    2.
    发明授权
    Pharmacokinetics of S-adenosylmethionine formulations 有权
    S-腺苷甲硫氨酸制剂的药代动力学

    公开(公告)号：US08329208B2

    公开(公告)日：2012-12-11

    申请号：US12845600

    申请日：2010-07-28

    Applicant: Nancy Harrison ,  I. David MacDonald ,  Aniko Takacs-Cox ,  Robert Miller

    Inventor： Nancy Harrison ,  I. David MacDonald ,  Aniko Takacs-Cox ,  Robert Miller

    IPC: A61K47/00 ,  A61K9/00 ,  A61K31/70

    CPC classification number: A61K31/7076 ,  A61K9/0002 ,  A61K9/0053 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/28 ,  A61K9/2886 ,  A61K9/50 ,  A61K47/38

    Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.

    Abstract translation: 提供了改善S-腺苷甲硫氨酸（SAMe）的药代动力学特征的组合物和方法，以及使用具有改善的药代动力学特征的SAMe制剂治疗各种疾病的方法。 更具体地，本发明涉及通过施用表现出改善的外源SAMe的药代动力学特征的制剂来治疗受试者的疾病或病症和/或改善受试者的营养状态的方法。 该方法还包括将抗生素治疗本发明组合物一天一次快速过夜的步骤; 那是在早上食物摄入之前。

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