公开(公告)号：US20250051728A1

公开(公告)日：2025-02-13

申请号：US18711318

申请日：2022-11-16

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Takanori IWATA ,  Satoru ONIZUKA

IPC: C12N5/0775 ,  A01N1/02

Abstract: The present invention is directed to obtaining a cell population comprising mesenchymal stem cells that are excellent in proliferative capability and osteoblastic differentiation capability and are useful for the regeneration of periodontal tissues. The present invention is also directed to providing a cell sheet and a method for producing a cell sheet, comprising, as a material, a cell population comprising mesenchymal stem cells that are excellent in proliferative capability and osteoblastic differentiation capability and are useful for the regeneration of periodontal tissues. A cell population having alkaline phosphatase activity before calcification induction of 1 U or more is selected and obtained from a cell population comprising mesenchymal stem cells derived from a dental or periodontal tissue. A cell sheet is obtained by the following steps (a) to (c): (a) obtaining a cell population comprising mesenchymal stem cells and having alkaline phosphatase activity; (b) culturing the cell population in a calcification induction medium, and proliferating the cell population on a plastic substrate; and (c) recovering and washing a sheet-shaped cell population formed on the plastic substrate.

公开(公告)号：US20240280595A1

公开(公告)日：2024-08-22

申请号：US18566478

申请日：2022-05-31

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Ryunosuke OHKAWA ,  Yume MUTSUDA ,  Yuna HORIUCHI ,  Takahiro KAMEDA ,  Minoru TOZUKA

IPC: G01N33/92 ,  G01N33/543 ,  G01N33/58

CPC classification number: G01N33/92 ,  G01N33/54326 ,  G01N33/582

Abstract: The present invention provides a novel method for measuring cholesterol efflux capacity. The present invention provides a method for measuring the cholesterol efflux capacity of HDL, the method including: a step for preparing magnetic beads obtained by converting cholesterol to a solid phase; a step for bringing the magnetic beads obtained by converting cholesterol to a solid phase into contact with an HDL-containing sample to be measured in a solution; and a step for separating the magnetic beads from the solution and measuring the amount of cholesterol in the solution after separating the magnetic beads.

公开(公告)号：US12066429B2

公开(公告)日：2024-08-20

申请号：US16913376

申请日：2020-06-26

Applicant: National University Corporation Tokyo Medical and Dental University ,  Nippon Zoki Pharmaceutical Co., Ltd.

Inventor： Hiroshi Asahara ,  Tomoki Chiba ,  Kentaro Abe

IPC: C12N15/11 ,  C12N15/10 ,  C12N15/113 ,  C12N15/63 ,  G01N33/50

CPC classification number: G01N33/5023 ,  C12N15/1086 ,  C12N15/113 ,  C12N15/63 ,  C12N2310/14 ,  C12N2310/18 ,  C12N2320/10 ,  C12N2320/50 ,  G01N2500/02 ,  G01N2500/10

Abstract: Provided are an expression inhibitor of an inflammation promoting factor based on the discovery of a new factor influencing the expression amount/level of an inflammation promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for immune diseases, inflammatory diseases, painful conditions and similar. More specifically provided are: an expression inhibitor of an inflammation promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS2 expression inhibitor and RBMS2 function inhibitor; a screening method using as an indicator the expression or the function of RBMS2; an expression cassette useful for the method; as well as a diagnostic agent containing a product detection agent for RBMS2 gene expression and disease detection method using as an indicator RBMS2 gene expression amount/level.

公开(公告)号：US20240240183A1

公开(公告)日：2024-07-18

申请号：US18563128

申请日：2022-05-24

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  OSAKA UNIVERSITY

Inventor： Takanori YOKOTA ,  Tetsuya NAGATA ,  Kotaro YOSHIOKA ,  Satoshi OBIKA

IPC: C12N15/113 ,  A61K9/00 ,  A61P29/00 ,  A61P37/06

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61P29/00 ,  A61P37/06 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2320/30

Abstract: A problem to be solved by the present invention is to provide a double-stranded nucleic acid complex having a reduced toxicity whose effectiveness is not impaired. Provided is a double-stranded nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein: said first nucleic acid strand is capable of hybridizing to at least part of a target gene or a transcription product thereof, and has an antisense effect on said target gene or transcription product thereof, said second nucleic acid strand comprises a base sequence complementary to said first nucleic acid strand, and said first nucleic acid strand and/or said second nucleic acid strand comprises at least one bridged non-natural nucleoside represented by formula (I) or formula (II) (wherein R represents a hydrogen atom or a methyl group).

公开(公告)号：US12004915B2

公开(公告)日：2024-06-11

申请号：US17043048

申请日：2019-03-28

Applicant: National University Corporation Tokyo Medical and Dental University

Inventor： Manabu Kanazawa ,  Yumika Soeda ,  Maiko Iwaki ,  Toshio Arakida ,  Tamaki Hada ,  Shunsuke Minakuchi

IPC: A61C13/36 ,  A61C13/00 ,  A61C13/01 ,  A61C13/34 ,  B29C65/00 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y80/00

CPC classification number: A61C13/1016 ,  A61C13/0004 ,  A61C13/0019 ,  A61C13/04 ,  A61C13/34 ,  B29C66/032 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y80/00

Abstract: Removable denture data of a removable denture is produced, and disk frame data of a disk frame in which the removable denture is accommodated is produced, thereby building the disk frame based on the disk frame data. Next, a resin disk in which artificial teeth are embedded is produced by arranging the artificial teeth in the disk frame and curing a base resin, and a denture base is milled by milling the resin disk based on the removable denture data, thereby manufacturing the removable denture in which a base side of the artificial teeth is embedded in the denture base. As a result, artificial teeth having an excellent aesthetics may be used, it is possible to firmly join the artificial teeth and the denture base to each other, and it is possible to manufacture a removable denture with a favorable restoration accuracy of the artificial teeth.

公开(公告)号：US20240158790A1

公开(公告)日：2024-05-16

申请号：US18392869

申请日：2023-12-21

Applicant: National University Corporation Tokyo Medical and Dental University ,  Osaka University

Inventor： Takanori Yokota ,  Kazutaka Nishina ,  Satoshi Obika ,  Hidehiro Mizusawa

IPC: C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/15 ,  C12N2310/3181 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2310/53 ,  C12N2320/52

Abstract: A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by RNase H when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5′ terminal side of the region, (c) one or more nucleotide analogs located on 3′ terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive RNA nucleotides.

公开(公告)号：US20240023862A1

公开(公告)日：2024-01-25

申请号：US18252932

申请日：2022-01-11

Applicant: Nobuyori NAGAOKA ,  Taishi WATANABE ,  Shigenori KAWABATA

Inventor： Nobuyori NAGAOKA ,  Taishi WATANABE ,  Shigenori KAWABATA

IPC: A61B5/248 ,  A61B5/00

CPC classification number: A61B5/248 ,  A61B5/743

Abstract: A diagnostic support apparatus includes a computing unit that computes a decreasing rate of a current intensity of an inward current flowing into a nerve pathway, based on magnetic field data obtained by measuring a magnetic field generated by a subject.

公开(公告)号：US20230414765A1

公开(公告)日：2023-12-28

申请号：US18463711

申请日：2023-09-08

Applicant: AGC INC. ,  THE UNIVERSITY OF TOKYO ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Mihoko HARA ,  Rintaro HARA ,  Kanjiro MIYATA ,  Mitsuru NAITO ,  Takanori YOKOTA

IPC: A61K47/59 ,  C08G69/48 ,  A61K47/60

CPC classification number: A61K47/595 ,  C08G69/48 ,  A61K47/60

Abstract: A polymer represented by the following formula (I):




wherein each symbol is as described in the specification, is useful as a drug carrier in effectively delivering a drug to a target site.

公开(公告)号：US11851654B2

公开(公告)日：2023-12-26

申请号：US16982274

申请日：2019-03-19

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Takanori Yokota ,  Tetsuya Nagata ,  Kotaro Yoshioka

IPC: C07H21/04 ,  C12N15/113 ,  A61P25/00 ,  A61K9/00

CPC classification number: C12N15/113 ,  A61K9/0085 ,  A61P25/00 ,  C12N2310/11

Abstract: An object of the invention is to provide a low toxicity antisense nucleic acid medicine that can modulate expression of a target transcriptional product in the central nervous system and other sites of a subject. Provided is a low toxicity composition for modulating expression of a target transcriptional product in a site such as the central nervous system of a subject, having a nucleic acid complex formed by annealing together a first nucleic acid strand having an antisense oligonucleotide region with respect to the target transcriptional product, and a second nucleic acid strand having a complementary region that is complementary to at least part of the first nucleic acid strand.

公开(公告)号：US11832842B2

公开(公告)日：2023-12-05

申请号：US16614970

申请日：2018-05-16

Applicant: SUMITOMO BAKELITE CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Hirokuni Arai ,  Toshifumi Sakate ,  Akira Kawamata ,  Shinetsu Harata

IPC: A61B17/30 ,  A61M39/10 ,  A61B17/00

CPC classification number: A61B17/30 ,  A61M39/10 ,  A61B2017/00477 ,  A61B2017/308 ,  A61B2217/005 ,  A61M2039/1038 ,  A61M2210/125

Abstract: The present invention provides a coronary artery bypass surgery treatment tool or the like including a flexible tube, a suction cup in which an opening portion is formed to communicate with the flexible tube and which is provided at a distal end of the flexible tube, a joint portion which has a suction path, a male connector which is provided in one of a proximal end of the flexible tube and a distal end of the suction path of the joint portion, and a female connector which is provided in the other thereof and is detachably connected to the male connector.