公开(公告)号：US20240301353A1

公开(公告)日：2024-09-12

申请号：US18575460

申请日：2022-06-30

Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY ,  KYOTO UNIVERSITY

Inventor： Naoya TAKAYAMA ,  Koji ETO ,  Sou NAKAMURA ,  Sudip Kumar PAUL

IPC: C12N5/0786 ,  C12N5/10

CPC classification number: C12N5/0645 ,  C12N5/10 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2510/04

Abstract: The present invention relates to a method for improving proliferative property of a CMP or a myeloid progenitor cell, including a step of forcibly expressing a MYC family gene and BMI1 gene in any cell in the process of differentiation from a hematopoietic progenitor cell into a myeloid progenitor cell, wherein the myeloid progenitor cell is a progenitor cell of macrophage, dendritic cell, granulocyte, erythroblast, or erythrocyte.

公开(公告)号：US11980595B2

公开(公告)日：2024-05-14

申请号：US16969713

申请日：2019-02-14

Applicant: National University Corporation Chiba University

Inventor： Kenji Hashimoto

IPC: A61K31/135 ,  A61P1/00 ,  A61P19/10

CPC classification number: A61K31/135 ,  A61P19/10

Abstract: This preventive or therapeutic agent for inflammatory diseases or bone diseases, and this pharmaceutical composition for preventing or treating inflammatory diseases or bone diseases include, as effective components, a compound represented by formula (1) or a pharmaceutically acceptable salt thereof.




[In formula (1), X is a hydrogen atom, a halogen atom, or a C1-C10 alkyl group that may be substituted; R1 is a C1-C10 alkyl group that may be substituted, a C1-C10 alkenyl group that may be substituted, or a C6-C14 aryl group that may be substituted; and one or more hydrogen atoms may be substituted with deuterium atoms.]

公开(公告)号：US11948740B2

公开(公告)日：2024-04-02

申请号：US16649845

申请日：2018-09-19

Applicant: National University Corporation Chiba University ,  TOMOEGAWA CORPORATION

Inventor： Katsuyoshi Hoshino ,  Yousuke Sugawara ,  Rio Yamada ,  Aoi Magori ,  Nobuyuki Aoki ,  Keiichiro Haji ,  Daisuke Muramatsu

IPC: H01G11/02 ,  H01G11/28 ,  H01G11/30 ,  H01G11/70

CPC classification number: H01G11/02 ,  H01G11/28 ,  H01G11/30 ,  H01G11/70

Abstract: To provide an electrode for an electricity storage device, which electrode employs a porous conductor having conductive nanostructures formed on its surface and makes it possible to provide a less expensive electricity storage device having a high discharge capacity and high charge/discharge cycle resistance.
A porous conductor which is used as an electrode for an electricity storage device has a plurality of conductive nanostructures on a surface of the porous conductor.

公开(公告)号：US11864885B2

公开(公告)日：2024-01-09

申请号：US17050292

申请日：2019-04-15

Applicant: MINEBEA MITSUMI INC. ,  NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY

Inventor： Shinsuke Todoroki ,  Shiroh Isono

IPC: A61B5/113 ,  A61B5/08

CPC classification number: A61B5/113 ,  A61B5/0816

Abstract: A biological state monitoring system (100) for monitoring a biological state of a subject on a bed (BD) over a predetermined monitoring period, includes: at least one load detector (11, 12, 13, 14) configured to detect a load of the subject on the bed; and a respiratory rate estimating unit (34) configured to successively obtain and output estimated values of a respiratory rate of the subject, based on a temporal variation of a detection value of the load detector. The monitoring period includes a body motion period in which the subject has a body motion, and a resting period in which the subject merely performs a respiration. In a case that the monitoring period shifts from a first resting period to the body motion period and then from the body motion period to a second resting period, the respiratory rate estimating unit outputs, in the body motion period and a predetermined period starting from the shifting from the body motion period to the second resting period, a last estimated value which is the latest among the estimated values obtained successively in the first resting period.

公开(公告)号：US20230364242A1

公开(公告)日：2023-11-16

申请号：US18247113

申请日：2021-09-30

Applicant: NISSAN CHEMICAL CORPORATION ,  NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY

Inventor： Soichi MONMA ,  Itsuko ISHII

IPC: A61K47/54 ,  A61K9/00 ,  A61K9/06 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K9/107

CPC classification number: A61K47/544 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K9/107

Abstract: An object of the present invention is to provide an external pharmaceutical composition that imparts light stability to a β-blocker (particularly propranolol hydrochloride) and is excellent in the balance between transdermal absorbability and skin retention, and the present invention provides a complex composed of a water-soluble β-blocker and lecithin, a method for producing the complex, an external pharmaceutical composition containing the complex, and the like. The complex or a dispersion in oil containing the complex is applied to an existing pharmaceutical external preparation formulation (for example, W/O type cream), and a complex containing a β-blocker is allowed to be present in the O phase, thereby avoiding contact with water or dissolved oxygen and reducing the risk of photolysis.

公开(公告)号：US11760833B2

公开(公告)日：2023-09-19

申请号：US17487686

申请日：2021-09-28

Applicant: FUJIFILM Business Innovation Corp. ,  National University Corporation Chiba University

Inventor： Wataru Yamada ,  Satoya Sugiura ,  Natsumi Kaneko ,  Katsuyoshi Hoshino

IPC: C08G61/12 ,  C03C17/32 ,  C03C17/44

CPC classification number: C08G61/126 ,  C03C17/32 ,  C03C17/44 ,  B05D2203/35 ,  C03C2217/72 ,  C08G2261/141 ,  C08G2261/1424 ,  C08G2261/3223 ,  C08G2261/36 ,  C08G2261/43 ,  C08G2261/71 ,  C08G2261/90

Abstract: A liquid composition includes a thiophene polymer; and at least one polymerization component selected from the group including a monomer and an oligomer.

公开(公告)号：US11701440B2

公开(公告)日：2023-07-18

申请号：US17047859

申请日：2019-04-15

Applicant: NIHON MEDI-PHYSICS CO., LTD. ,  National University Corporation Kagoshima University ,  National University Corporation Chiba University

Inventor： Shota Komoto ,  Yu Ogawa ,  Yoshinari Shoyama ,  Tadashi Hatano ,  Yuji Ito ,  Yasushi Arano ,  Hiroyuki Suzuki ,  Tomoya Uehara

IPC: A61K47/68 ,  A61K51/10 ,  C07K5/065 ,  C07K5/087 ,  A61K51/04 ,  A61K51/08 ,  C07D257/02 ,  C07K7/08 ,  C07K16/32

CPC classification number: A61K51/1093 ,  A61K47/6887 ,  A61K47/6889 ,  A61K51/0482 ,  A61K51/088 ,  A61K51/1096 ,  C07D257/02 ,  C07K5/06078 ,  C07K5/0812 ,  C07K7/08 ,  C07K16/32 ,  C07K2317/21

Abstract: Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.

公开(公告)号：US11648705B2

公开(公告)日：2023-05-16

申请号：US16979332

申请日：2019-03-20

Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY ,  MAEDA CORPORATION

Inventor： Gakuhito Hirasawa ,  Takashi Tsunakawa ,  Daisaku Yamato

IPC: B27C9/04 ,  B25J11/00 ,  B23Q17/24 ,  B27B27/04

CPC classification number: B27C9/04 ,  B25J11/0055 ,  B23Q17/24 ,  B27B27/04

Abstract: Provided is a wood processing system including a wood conveying device having a longitudinal direction along one direction in the horizontal direction and being capable of conveying wood along the longitudinal direction; a multi-axis processing machine arranged on one side in the longitudinal direction of the wood conveying device, the multi-axis processing machine including a spindle capable of being attached with a first tool, and a spindle moving device having two or more linear axes perpendicular to one another and two or more rotational axes for moving the spindle; and at least one multi-articulated robot arranged along the wood conveying device on the other side in the longitudinal direction of the wood conveying device, the at least one multi-articulated robot including a wrist capable of being attached with a tool unit including a second tool, and an arm having six or more rotational axes for moving the wrist.

公开(公告)号：US20230030814A1

公开(公告)日：2023-02-02

申请号：US17783097

申请日：2020-12-11

Applicant: National University Corporation Chiba University ,  Kyoto University

Inventor： Seiji Ohtori ,  Yasuhiro Shiga ,  Kentaro Kosaka ,  Koji Eto

IPC: A61K35/19 ,  A61K9/19 ,  A61P19/00 ,  A61P17/02 ,  A61K38/18

Abstract: The problem that differences among lots in components and amounts of growth factors and the like in platelet-rich plasmas derived from an autologous plasma and the freeze-dried preparations thereof are large, and the effects of the lots are not kept constant is solved.
Specifically, a freeze-dried preparation comprising megakaryocytes and platelets induced to differentiate from stem cells, a pharmaceutical composition comprising the freeze-dried preparation, and the like are provided.

公开(公告)号：US11491467B2

公开(公告)日：2022-11-08

申请号：US16970015

申请日：2018-10-01

Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY ,  JGC Corporation

Inventor： Satoshi Sato ,  Yuchao Wang ,  Kazunori Honda

IPC: B01J23/10 ,  B01J21/04 ,  B01J21/08 ,  B01J21/18 ,  B01J27/224 ,  B01J37/08 ,  C07C1/24

Abstract: Provided is a technology for efficiently manufacturing 1,3-butadiene from 1,4-butanediol or 3-buten-1-ol in a reaction condition with a high conversion rate. A catalyst for manufacturing 1,3-butadiene, contains: ytterbium oxide as an active component for generating 1,3-butadiene from 1,4-butanediol or 3-buten-1-ol. In addition, a manufacturing method of 1,3-butadiene, includes: a step of obtaining a fluid containing 1,3-butadiene by bringing at least one of 1,4-butanediol and 3-buten-1-ol into contact with the catalyst for manufacturing 1,3-butadiene.