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公开(公告)号：US20230030814A1
公开(公告)日：2023-02-02
申请号：US17783097
申请日：2020-12-11
Inventor： Seiji Ohtori , Yasuhiro Shiga , Kentaro Kosaka , Koji Eto
Abstract: The problem that differences among lots in components and amounts of growth factors and the like in platelet-rich plasmas derived from an autologous plasma and the freeze-dried preparations thereof are large, and the effects of the lots are not kept constant is solved.
Specifically, a freeze-dried preparation comprising megakaryocytes and platelets induced to differentiate from stem cells, a pharmaceutical composition comprising the freeze-dried preparation, and the like are provided.-
公开(公告)号：US20240287511A1
公开(公告)日：2024-08-29
申请号：US18290183
申请日：2022-05-13
Inventor： Koutaro Yokote , Yasuo Ouchi , Hisaya Kato , Koji Eto , Yoshiro Maezawa
IPC: C12N15/113 , A61P43/00 , C12N15/86
CPC classification number: C12N15/113 , A61P43/00 , C12N15/86 , C12N2310/11 , C12N2310/3233 , C12N2740/15043
Abstract: The present invention is to provide an antisense oligomer or a pharmaceutically acceptable salt thereof capable of treating Werner syndrome without direct repair of a mutated gene. The present invention provides an antisense oligomer or a pharmaceutically acceptable salt thereof which consists of a base sequence complementary to the base sequence of the following (i) or (ii): (i) a contiguous base sequence of 15 or more bases in the base sequence shown in SEQ ID NO: 1; or (ii) a contiguous base sequence of 15 or more bases in the base sequence shown in SEQ ID NO: 1, having deletion, substitution, or insertion of one or more bases; and which is capable of causing skipping of the 27th exon in a human WRN gene.
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公开(公告)号：US11976301B2
公开(公告)日：2024-05-07
申请号：US17209035
申请日：2021-03-22
Applicant: Megakaryon Corporation , Kyoto University
Inventor： Takeaki Dohda , Sachiko Kobayashi , Koji Eto , Hiroshi Endo , Sou Nakamura
CPC classification number: C12N5/0644 , C12N2500/25 , C12N2500/38 , C12N2501/125 , C12N2501/145 , C12N2501/727 , C12N2501/998 , C12N2506/45 , C12N2510/00
Abstract: The present invention provides a method for producing megakaryocytes that have an increased capacity to produce platelets, the method comprising a step of culturing, under conditions that cause the death of cells that do not express a gene that is specifically expressed by megakaryocytes, cells that have the capacity to differentiate into megakaryocytes.
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公开(公告)号：US11136547B2
公开(公告)日：2021-10-05
申请号：US16083503
申请日：2017-03-22
Applicant: Kyoto University , Megakaryon Corporation
Inventor： Koji Eto , Hiroshi Endo , Yukitaka Ito , Junichi Fukunaga
IPC: A61K35/19 , A61K35/28 , A61K35/545 , C12N5/0735 , C12N5/078 , C12N5/00 , C12N5/10 , C12N15/09 , A61P7/08 , A61K38/18 , C12N5/074
Abstract: Provided is a method for inducing mesoderm, comprising a step of bringing pluripotent stem cells into contact with bone morphogenetic protein 4 (BMP4) or CHIR for at least 3 days.
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公开(公告)号：US20210222124A1
公开(公告)日：2021-07-22
申请号：US17209035
申请日：2021-03-22
Applicant: Megakaryon Corporation , Kyoto University
Inventor： Takeaki Dohda , Sachiko Kobayashi , Koji Eto , Hiroshi Endo , Sou Nakamura
IPC: C12N5/078
Abstract: The present invention provides a method for producing megakaryocytes that have an increased capacity to produce platelets, the method comprising a step of culturing, under conditions that cause the death of cells that do not express a gene that is specifically expressed by megakaryocytes, cells that have the capacity to differentiate into megakaryocytes.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20210062158A1
公开(公告)日：2021-03-04
申请号：US16839906
申请日：2020-04-03
Applicant: Kyoto University , Megakaryon Corporation
Inventor： Koji Eto , Hiroshi Endo , Tomohiro Shigemori
Abstract: Provided is a method for producing a stem cell clone, which comprises the steps of: (i) introducing into stem cells an exogenous gene associated with induction of differentiation into somatic cells; (ii) inducing differentiation of the stem cells, introduced with an exogenous gene, into the somatic cells; (iii) dedifferentiating the differentiation-induced somatic cells; and (iv) isolating stem cells having the exogenous gene incorporated into a chromosome thereof from a colony of the stem cells formed in step (iii).
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公开(公告)号：US20190032015A1
公开(公告)日：2019-01-31
申请号：US16071598
申请日：2017-01-30
Applicant: Kyoto University , MEGAKARYON CORPORATION
Inventor： Koji Eto , Hideya Seo , Akira Ota , Yukitaka Ito , Yasuko Hazama
IPC: C12N5/078
Abstract: The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.
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8.发明公开公开(公告)号：US20240026304A1
公开(公告)日：2024-01-25
申请号：US18476065
申请日：2023-09-27
Applicant: Kyoto University , Megakaryon Corporation
Inventor： Koji Eto , Hiroshi Endo , Tomohiro Shigemori
CPC classification number: C12N5/0696 , C12N5/0644 , C12N2506/11 , C12N2506/45 , C12N2510/00
Abstract: Provided is a method for producing a stem cell clone, which comprises the steps of: (i) introducing into stem cells an exogenous gene associated with induction of differentiation into somatic cells; (ii) inducing differentiation of the stem cells, introduced with an exogenous gene, into the somatic cells; (iii) dedifferentiating the differentiation-induced somatic cells; and (iv) isolating stem cells having the exogenous gene incorporated into a chromosome thereof from a colony of the stem cells formed in step (iii).
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公开(公告)号：US11016083B2
公开(公告)日：2021-05-25
申请号：US16071716
申请日：2017-01-30
Applicant: Kyoto University , Megakaryon Corporation
Inventor： Koji Eto , Hideya Seo , Akira Ota , Yukitaka Ito , Yasuko Hazama
IPC: C12N15/09 , C12Q1/6897 , G01N33/50 , C12N15/10
Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
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公开(公告)号：US20190048317A1
公开(公告)日：2019-02-14
申请号：US15735685
申请日：2016-06-16
Applicant: Kyoto University , Megakaryon Corporation
Inventor： Koji Eto , Sou Nakamura , Yukitaka Ito , Tomohiro Shigemori , Takeaki Dohda
IPC: C12N5/078 , A61K31/553 , A61K35/19 , A61K31/551 , C12N5/077
Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
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