公开(公告)号：US20240287511A1

公开(公告)日：2024-08-29

申请号：US18290183

申请日：2022-05-13

Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY

Inventor： Koutaro Yokote ,  Yasuo Ouchi ,  Hisaya Kato ,  Koji Eto ,  Yoshiro Maezawa

IPC: C12N15/113 ,  A61P43/00 ,  C12N15/86

CPC classification number: C12N15/113 ,  A61P43/00 ,  C12N15/86 ,  C12N2310/11 ,  C12N2310/3233 ,  C12N2740/15043

Abstract: The present invention is to provide an antisense oligomer or a pharmaceutically acceptable salt thereof capable of treating Werner syndrome without direct repair of a mutated gene. The present invention provides an antisense oligomer or a pharmaceutically acceptable salt thereof which consists of a base sequence complementary to the base sequence of the following (i) or (ii): (i) a contiguous base sequence of 15 or more bases in the base sequence shown in SEQ ID NO: 1; or (ii) a contiguous base sequence of 15 or more bases in the base sequence shown in SEQ ID NO: 1, having deletion, substitution, or insertion of one or more bases; and which is capable of causing skipping of the 27th exon in a human WRN gene.

公开(公告)号：US20230030814A1

公开(公告)日：2023-02-02

申请号：US17783097

申请日：2020-12-11

Applicant: National University Corporation Chiba University ,  Kyoto University

Inventor： Seiji Ohtori ,  Yasuhiro Shiga ,  Kentaro Kosaka ,  Koji Eto

IPC: A61K35/19 ,  A61K9/19 ,  A61P19/00 ,  A61P17/02 ,  A61K38/18

Abstract: The problem that differences among lots in components and amounts of growth factors and the like in platelet-rich plasmas derived from an autologous plasma and the freeze-dried preparations thereof are large, and the effects of the lots are not kept constant is solved.
Specifically, a freeze-dried preparation comprising megakaryocytes and platelets induced to differentiate from stem cells, a pharmaceutical composition comprising the freeze-dried preparation, and the like are provided.