公开(公告)号：US20240365440A1

公开(公告)日：2024-10-31

申请号：US18647951

申请日：2024-04-26

申请人： The Board of Trustees of the University of Illinois

发明人： Siavash Khodakarami ,  Nenad Miljkovic ,  Longnan Li ,  Muhammad Jahidul Hoque ,  Alexandra Efterpy Solecki ,  Pouya Kabirzadeh ,  Wentao Yang ,  Andrew Stillwell ,  Nicole Stokowski

IPC分类号： H05B3/26 ,  B64D15/12

CPC分类号： H05B3/26 ,  B64D15/12

摘要： A system configured for electro-thermal defrosting, desnowing and/or deicing includes (a) a component susceptible to accumulation of ice, frost, and/or snow, and (b) an electro-thermal multilayer on the component. The electro-thermal multilayer comprises a heating layer on an insulating layer, where the heating layer is configured for electrical connection to a source of pulsed power. The electro-thermal multilayer optionally includes a superhydrophobic layer. The component may be a photovoltaic panel, a wind turbine blade, a heat exchanger coil or fin, or an aircraft wing, e.g., of an electrified aircraft. The electro-thermal multilayer may be adhered to the component as a coating or removably secured to the component as a module.

公开(公告)号：US12121597B2

公开(公告)日：2024-10-22

申请号：US16654569

申请日：2019-10-16

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： King C Li ,  Jeffrey S Moore

IPC分类号： A61K49/00 ,  A61K41/00 ,  G01N21/70

CPC分类号： A61K49/0054 ,  A61K41/0028 ,  G01N21/70

摘要： Provided herein are compositions and methods for remotely and non-invasively subjecting targeted biological structures with light emissions or chromogenic changes.

公开(公告)号：US12084456B2

公开(公告)日：2024-09-10

申请号：US17299365

申请日：2019-12-04

申请人： The Board of Trustees of the University of Illinois

发明人： David Sarlah ,  Tanner W. Bingham ,  Lucas William Hernandez

IPC分类号： C07D491/056 ,  B01J31/22

CPC分类号： C07D491/056 ,  B01J31/22 ,  B01J2531/16

摘要： Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based on the development of a Ni-catalyzed dearomative trans-1,2-carboamination of benzene. The effectiveness of this dearomatization approach is notable, as only two additional olefin functionalizations are needed to construct the fully decorated aminocyclitol cores of these alkaloids. Installation of the lactam ring has been achieved through several pathways and a direct interconversion between natural products was established via a late-stage C-7 cupration. Using this synthetic blueprint, we were able to produce natural products on a gram scale and provide tailored analogs with improved activity, solubility, and metabolic stability.

公开(公告)号：US12084411B2

公开(公告)日：2024-09-10

申请号：US17046608

申请日：2019-04-12

申请人： The Board of Trustees of the University of Illinois

发明人： Martin D. Burke ,  Anthony S. Grillo ,  Alexander G. Cioffi ,  Anna SantaMaria ,  Daniel Blair ,  Andrew Blake

IPC分类号： C07C45/68 ,  A61K45/06 ,  C07C61/22

CPC分类号： C07C45/68 ,  A61K45/06 ,  C07C61/22

摘要： Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.

公开(公告)号：US12074213B2

公开(公告)日：2024-08-27

申请号：US17357697

申请日：2021-06-24

申请人： The Board of Trustees of the University of Illinois

发明人： Ralph G. Nuzzo ,  John A. Rogers ,  Etienne Menard ,  Keon Jae Lee ,  Dahl-Young Khang ,  Yugang Sun ,  Matthew Meitl ,  Zhengtao Zhu

IPC分类号： H01L29/76 ,  B82Y10/00 ,  H01L21/02 ,  H01L21/308 ,  H01L21/322 ,  H01L21/683 ,  H01L23/00 ,  H01L23/02 ,  H01L25/075 ,  H01L27/12 ,  H01L29/04 ,  H01L29/06 ,  H01L29/12 ,  H01L29/786 ,  H01L31/0392 ,  H01L31/18 ,  H01L33/00 ,  H01L33/32

CPC分类号： H01L29/76 ,  B82Y10/00 ,  H01L21/02521 ,  H01L21/02603 ,  H01L21/02628 ,  H01L21/308 ,  H01L21/322 ,  H01L21/6835 ,  H01L23/02 ,  H01L24/03 ,  H01L24/80 ,  H01L24/83 ,  H01L24/97 ,  H01L25/0753 ,  H01L27/1285 ,  H01L27/1292 ,  H01L29/04 ,  H01L29/06 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/068 ,  H01L29/12 ,  H01L29/78603 ,  H01L29/78681 ,  H01L29/78696 ,  H01L31/0392 ,  H01L31/03926 ,  H01L31/1804 ,  H01L31/1864 ,  H01L31/1896 ,  H01L33/007 ,  H01L33/0093 ,  H01L33/32 ,  B81C2201/0185 ,  H01L24/05 ,  H01L24/08 ,  H01L24/29 ,  H01L24/32 ,  H01L24/94 ,  H01L2221/68368 ,  H01L2221/68381 ,  H01L2224/03 ,  H01L2224/0332 ,  H01L2224/0345 ,  H01L2224/03614 ,  H01L2224/0362 ,  H01L2224/05073 ,  H01L2224/05082 ,  H01L2224/05124 ,  H01L2224/05144 ,  H01L2224/05155 ,  H01L2224/05166 ,  H01L2224/05552 ,  H01L2224/05553 ,  H01L2224/05554 ,  H01L2224/05555 ,  H01L2224/05644 ,  H01L2224/05666 ,  H01L2224/08225 ,  H01L2224/2919 ,  H01L2224/32225 ,  H01L2224/80 ,  H01L2224/80006 ,  H01L2224/80121 ,  H01L2224/80862 ,  H01L2224/80895 ,  H01L2224/83 ,  H01L2224/83005 ,  H01L2224/83121 ,  H01L2224/83192 ,  H01L2224/83193 ,  H01L2224/8385 ,  H01L2224/83862 ,  H01L2224/9202 ,  H01L2224/94 ,  H01L2224/95 ,  H01L2224/97 ,  H01L2924/00012 ,  H01L2924/01032 ,  H01L2924/0665 ,  H01L2924/10253 ,  H01L2924/10329 ,  H01L2924/12032 ,  H01L2924/12036 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/12044 ,  H01L2924/1305 ,  H01L2924/13055 ,  H01L2924/1306 ,  H01L2924/13063 ,  H01L2924/13091 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/15159 ,  H01L2924/15162 ,  H01L2924/15788 ,  H01L2924/1579 ,  Y02E10/547 ,  Y02P70/50 ,  Y10S977/707 ,  Y10S977/724 ,  H01L2224/05644 ,  H01L2924/00014 ,  H01L2224/05124 ,  H01L2924/00014 ,  H01L2224/0332 ,  H01L2924/00014 ,  H01L2224/97 ,  H01L2224/80 ,  H01L2224/97 ,  H01L2224/83 ,  H01L2224/80121 ,  H01L2924/00012 ,  H01L2224/83121 ,  H01L2924/00012 ,  H01L2224/9202 ,  H01L2224/03 ,  H01L2224/05666 ,  H01L2924/00014 ,  H01L2224/2919 ,  H01L2924/0665 ,  H01L2224/94 ,  H01L2224/03 ,  H01L2224/05155 ,  H01L2924/00014 ,  H01L2224/05144 ,  H01L2924/01032 ,  H01L2224/05082 ,  H01L2224/05644 ,  H01L2224/05155 ,  H01L2224/05144 ,  H01L2924/01032 ,  H01L2224/05073 ,  H01L2224/05644 ,  H01L2224/05166 ,  H01L2224/05166 ,  H01L2924/00014 ,  H01L2224/05555 ,  H01L2924/00014 ,  H01L2224/05554 ,  H01L2924/00014 ,  H01L2224/05553 ,  H01L2924/00014 ,  H01L2224/05552 ,  H01L2924/00012 ,  H01L2224/83192 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2924/13091 ,  H01L2924/00 ,  H01L2924/1306 ,  H01L2924/00 ,  H01L2924/1461 ,  H01L2924/00 ,  H01L2924/1305 ,  H01L2924/00 ,  H01L2924/12032 ,  H01L2924/00 ,  H01L2924/15788 ,  H01L2924/00 ,  H01L2924/12036 ,  H01L2924/00 ,  H01L2924/12042 ,  H01L2924/00 ,  H01L2924/12043 ,  H01L2924/00 ,  H01L2924/12044 ,  H01L2924/00 ,  H01L2924/13063 ,  H01L2924/00 ,  H01L2924/14 ,  H01L2924/00 ,  H01L2924/13055 ,  H01L2924/00

摘要： The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.

公开(公告)号：US20240269671A1

公开(公告)日：2024-08-15

申请号：US18566455

申请日：2022-06-06

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Igor Paprotny ,  Michael S. Caffrey ,  Nitin S. Jayakumar

IPC分类号： B01L3/00 ,  C12Q1/70

CPC分类号： B01L3/502715 ,  C12Q1/70 ,  B01L2200/16 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/02 ,  B01L2400/043

摘要： The disclosure provides example devices and methods for virus and bacterium detection and identification. The example device includes (a) a housing having an air inlet and an air outlet, (b) a substrate disposed within the housing, where the at least one substrate has a through-slot, where the substrate has a plurality of wells, (c) an air-handling and precipitation chamber, a reagent and reaction chamber, and a detection chamber arranged in series and each coupled to the top surface of the substrate, (d) a first actuator coupled to the substrate and configured to rotate the substrate, (e) a second actuator coupled to and configured to rotate the air-handling and precipitation chamber, the reagent and reaction chamber, and the detection chamber, and (f) at least one processor electrically coupled to the air-handling and precipitation chamber, the reagent and reaction chamber, the detection chamber, the first actuator, and the second actuator.

公开(公告)号：US12054727B2

公开(公告)日：2024-08-06

申请号：US16808881

申请日：2020-03-04

申请人： The Board of Trustees of the University of Illinois ,  The Regents of the University of California

发明人： Stephen P. Long ,  Katarzyna Glowacka ,  Johannes Kromdijk ,  Krishna K. Niyogi ,  Laurie Beth Leonelli

IPC分类号： C12N15/82

CPC分类号： C12N15/8273

摘要： Aspects of the present disclosure relate to methods of cultivating genetically altered plants with increased activity of the PsbS protein. These genetically altered plants have increased water use efficiency and substantially similar photosynthetic efficiency as compared to WT plants grown under the same conditions.

公开(公告)号：US12050810B2

公开(公告)日：2024-07-30

申请号：US17935912

申请日：2022-09-27

申请人： The Board of Trustees of the University of Illinois

发明人： Ahmed Abulila ,  Nam Sung Kim ,  Izzat El Hajj

IPC分类号： G06F15/82 ,  G06F3/06

CPC分类号： G06F3/0659 ,  G06F3/061 ,  G06F3/0673

摘要： Systems and methods for hardware-based asynchronous logging include: initiating first and second atomic regions on first and second cores of a central processing unit (CPU); and asynchronously logging data for the first atomic region and the second atomic region using the CPU by: asynchronously performing log persist operations (LPOs) to log an old data value from each atomic region; updating the old data value to a new data value from each atomic region; tracking dependencies between the first atomic region and the second atomic region using a memory controller; asynchronously performing data persist operations (DPOs) to persist the new data value for each atomic region; and committing the first atomic region and the second atomic region based on the dependencies using the memory controller of the CPU.

公开(公告)号：US20240240196A1

公开(公告)日：2024-07-18

申请号：US18563824

申请日：2022-05-26

申请人： The Board of Trustees of the University of Illinois

发明人： Stephen P. LONG ,  Yu WANG ,  Kher Xing CHAN

IPC分类号： C12N15/82 ,  C12N9/12 ,  C12N9/88

CPC分类号： C12N15/8269 ,  C12N9/1294 ,  C12N9/88 ,  C12N15/8213 ,  C12Y207/09001 ,  C12Y401/01039

摘要： Aspects of the present disclosure relate to genetically altered plants with increased activity of one or more of a PPDK regulatory protein (PDRP), a Rubisco activase (Rea) protein, or a Rubisco protein that have increased photosynthetic efficiency under fluctuating light conditions. Further, aspects of the present disclosure relate to methods of producing and cultivating the genetically altered plants of the present disclosure.

公开(公告)号：US12030901B2

公开(公告)日：2024-07-09

申请号：US18056089

申请日：2022-11-16

申请人： THE TRUSTEES OF INDIANA UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Tom G. Driver ,  Roberto F. Machado ,  Naijing Su ,  Xinyu Guan ,  Wrickban Mazumdar ,  Kira Ratia ,  Jason Ralph Hickok ,  Angelia Denise Lockett

IPC分类号： C07F7/08 ,  C07D401/12 ,  C07D491/056

CPC分类号： C07F7/0816 ,  C07D401/12 ,  C07D491/056

摘要： Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.